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Sertoli-Leydig细胞瘤1例报道并文献复习
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Abstract:
Sertoli-Leydig细胞瘤是一种性索间质肿瘤，是由不同分化程度的Sertoli细胞、类似睾丸网上皮细胞的瘤细胞、类似纤维母细胞和Leydig细胞的瘤细胞构成，瘤组织可由上述单一的一种细胞或多种细胞混合构成。在妇科肿瘤中少见，临床症状不典型，因此易误诊、漏诊。本文报道一例60岁女性Sertoli-Leydig细胞瘤，该患者因腹痛就诊，B超、盆腔CT等均提示盆腔占位，通过手术治疗及化疗，患者痊愈。通过对该病例进行分析，为以后Sertoli-Leydig细胞瘤的治疗研究提供参考。
Sertoli-Leydig cell tumor is a type of sex cord-stromal tumor, which is composed of Sertoli cells with different degrees of differentiation, tumor cells similar to the epithelial cells of the rete testis, tumor cells similar to fibroblasts and Leydig cells. The tumor tissue can be composed of a single type of the above cells or a mixture of multiple types of cells. It is rare among gynecological tumors, and its clinical symptoms are not typical, so it is prone to misdiagnosis. This article reports a 60-year-old female patient with Sertoli-Leydig cell tumor. The patient presented with abdominal pain, and B-ultrasound, pelvic CT, etc. all suggested a pelvic space-occupying lesion. The patient was cured through surgical treatment and chemotherapy. By analyzing this case, it provides a reference for the treatment research of Sertoli-Leydig cell tumor in the future.
| [1] | Virk, R. and Lu, D. (2010) Mucinous Adenocarcinoma as Heterologous Element in Intermediately Differentiated Sertoli-Leydig Cell Tumor of the Ovary. Pathology-Research and Practice, 206, 489-492. https://doi.org/10.1016/j.prp.2009.07.012 |
| [2] | Young, R.H. and Scully, R.E. (1985) Ovarian Sertoli-Leydig Cell Tumors. The American Journal of Surgical Pathology, 9, 543-569. https://doi.org/10.1097/00000478-198508000-00001 |
| [3] | 张红梅, 高娜, 白爽, 刘文超, 范黎. 卵巢睾丸母细胞瘤1例[J]. 临床肿瘤学杂志, 2014, 19(6): 573-574. |
| [4] | Brandone, N., Borrione, C., Rome, A. and de Paula, A.M. (2018) La tumeur de sertoli-leydig ovarienne: Une tumeur qui peut être piégeuse. Annales de Pathologie, 38, 131-136. https://doi.org/10.1016/j.annpat.2018.01.002 |
| [5] | Villegas Cruz, C., Berlanga Narro, S., Saltijeral, S.N. and Roman Montalvo, M.A. (2024) Sertoli-Leydig Cell Tumor. International Journal of Gynecological Cancer, 34, 1476-1478. https://doi.org/10.1136/ijgc-2023-004321 |
| [6] | 郭立文, 陈惠华. 卵巢支持-间质细胞瘤1例报道并文献复习[J]. 中国计划生育和妇产科, 2018, 10(11): 92-94. |
| [7] | Roth, L.M., Anderson, M.C., Govan, A.D.T., Langley, F.A., Gowing, N.F.C. and Woodcock, A.S. (1981) Sertoli-Leydig Cell Tumors: A Clinicopathologic Study of 34 Cases. Cancer, 48, 187-197. https://doi.org/10.1002/1097-0142(19810701)48:1<187::aid-cncr2820480130>3.0.co;2-1 |
| [8] | Balazs, E.A. (1973) The Vitreous. International Ophthalmology Clinics, 13, 169-187. https://doi.org/10.1097/00004397-197301330-00014 |
| [9] | Al-Hussaini, M., Al-Othman, Y., Hijazi, E. and McCluggage, W.G. (2018) A Report of Ovarian Sertoli-Leydig Cell Tumors with Heterologous Intestinal-Type Glands and Alpha Fetoprotein Elevation and Review of the Literature. International Journal of Gynecological Pathology, 37, 275-283. https://doi.org/10.1097/PGP.0000000000000408 |
| [10] | Chen, V.W., Ruiz, B., Killeen, J.L., Coté, T.R., Wu, X.C., Correa, C.N., et al. (2003) Pathology and Classification of Ovarian Tumors. Cancer, 97, 2631-2642. https://doi.org/10.1002/cncr.11345 |
| [11] | Bhat, R.A., Lim, Y.K., Chia, Y.N. and Yam, K.L. (2012) Sertoli‐Leydig Cell Tumor of the Ovary: Analysis of a Single Institution Database. Journal of Obstetrics and Gynaecology Research, 39, 305-310. https://doi.org/10.1111/j.1447-0756.2012.01928.x |
| [12] | Gui, T., Cao, D., Shen, K., Yang, J., Zhang, Y., Yu, Q., et al. (2012) A Clinicopathological Analysis of 40 Cases of Ovarian Sertoli-Leydig Cell Tumors. Gynecologic Oncology, 127, 384-389. https://doi.org/10.1016/j.ygyno.2012.07.114 |
| [13] | Liu, S., Pokoradi, A.J., Soboleski, D., Childs, T. and Agrawal, A. (2023) DICER1 Mutation in Recurrent Ovarian Sertoli-Leydig Cell Tumor: A Case Report. Journal of Pediatric and Adolescent Gynecology, 36, 107-111. https://doi.org/10.1016/j.jpag.2022.11.003 |
| [14] | de Kock, L., Terzic, T., McCluggage, W.G., Stewart, C.J.R., Shaw, P., Foulkes, W.D., et al. (2017) DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors. American Journal of Surgical Pathology, 41, 1178-1187. https://doi.org/10.1097/pas.0000000000000895 |
| [15] | De Paolis, E., Paragliola, R. and Concolino, P. (2021) Spectrum of DICER1 Germline Pathogenic Variants in Ovarian Sertoli-Leydig Cell Tumor. Journal of Clinical Medicine, 10, Article 1845. https://doi.org/10.3390/jcm10091845 |
| [16] | Mourinho Bala, N., Aragüés, J.M., Guerra, S., Brito, D. and Valadas, C. (2021) Ovarian Leydig Cell Tumor: Cause of Virilization in a Postmenopausal Woman. American Journal of Case Reports, 22, e933126. https://doi.org/10.12659/ajcr.933126 |
| [17] | Ravichandaran, A., Lakshmanan, A., Kurian, A. and Prasad, S. (2021) Moderately Differentiated Sertoli-Leydig Cell Tumor of Ovary with Associated Mucinous Carcinoma and Carcinoid—A Case Report and Review of Literature. Indian Journal of Pathology and Microbiology, 64, 528-531. https://doi.org/10.4103/ijpm.ijpm_672_20 |
| [18] | Zaloudek, C. and Norris, H.J. (1984) Sertoli-Leydig Tumors of the Ovary a Clinicopathologic Study of 64 Intermediate and Poorly Differentiated Neoplasms. The American Journal of Surgical Pathology, 8, 405-418. https://doi.org/10.1097/00000478-198406000-00001 |
| [19] | Bekker, P., Miland-Samuelsen, A.R., Smerdel, M.P., Schnack, T.H., Lauszus, F.F. and Karstensen, S.H. (2023) Sertoli-Leydig Cell Tumor: A Clinicopathological Analysis in a Comprehensive, National Cohort. International Journal of Gynecological Cancer, 33, 1921-1927. https://doi.org/10.1136/ijgc-2023-004945 |
