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Medical Diagnosis 2025
RSK4在现代生物医学中的研究进展
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Abstract:
RSK4作为一种核糖体S6激酶，可以通过整合多种信号通路调控下游蛋白，影响细胞增殖、分化、凋亡等生物学过程。近年来研究发现，RSK4在不同组织及疾病状态下的表达与作用存在显著差异。如在肿瘤疾病中，RSK4的作用尤为复杂，在乳腺癌等肿瘤中表现为抑癌作用，而在肾透明细胞癌等肿瘤中则呈现促癌作用。在非肿瘤性疾病如炎症性肠病和神经退行性疾病中，RSK4发挥着调节炎症、调控神经环路等潜在作用。鉴于其表达特异性与作用复杂性，目前RSK4在某些方面的作用仍存在争议。本文通过综述RSK4不同生物学作用以及相关的研究进展，旨在揭示该分子在疾病发生发展中的作用机制，为未来临床治疗工作提供理论依据。
Ribosomal S6 kinase 4 (RSK4), a member of the ribosomal S6 kinase family, integrates multiple signaling pathways to regulate downstream proteins, thereby influencing cellular processes such as proliferation, differentiation, and apoptosis. Recent studies have shown that RSK4 expression and function vary significantly across different tissues and disease states. In cancer, RSK4 exhibits a complex role: it acts as a tumor suppressor in breast cancer, yet displays oncogenic properties in renal clear cell carcinoma. Beyond oncology, RSK4 plays potential roles in regulating inflammation in inflammatory bowel disease and modulating neural circuits in neurodegenerative diseases. Despite these findings, RSK4’s actions remain controversial due to its expression specificity and complexity. This review summarizes RSK4’s diverse biological functions and research progress, aiming to elucidate its mechanisms in disease pathogenesis and provide a theoretical basis for future clinical treatments.
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