Background: Metabolic control is a major concern for the prevention of metabolic disorders. Saffron and Melissa officinalis are natural sources of antioxidants that can reduce the risk of metabolic diseases. This study aimed to identify and highlight the effects of saffron and Melissa officinalis on glycemic markers. Methods: Four research sources were examined in randomized controlled trials on the effects of saffron and Melissa officinalis on glycemic markers. Several studies have explored the effects of saffron and Melissa officinalis (lemon balm) on glycemic markers and their antidiabetic properties. Some studies have shown positive effects, such as decreased serum levels of FPG in patients with type 2 diabetes. Other studies have shown significant reductions in triglyceride and glycated hemoglobin levels, but no significant difference in glycemic control. Studies have also investigated the effects of saffron with concurrent training, resistance training, aerobic training, or both. Conclusion: Research shows that saffron and Melissa officinalis L significantly affect glycemic markers, including FPG, HbA1c, HOMA-IR, and insulin resistance, providing valuable insights for patients with diabetes. Future research should explore the effects of saffron and Melissa officinalis L on glycemic markers, involving in vitro and in vivo studies and larger randomized controlled trials.
References
[1]
Roshanravan, B., Samarghandian, S., Ashrafizadeh, M., Amirabadizadeh, A., Saeedi, F. and Farkhondeh, T. (2020) Metabolic Impact of Saffron and Crocin: An Updated Systematic and Meta-Analysis of Randomised Clinical Trials. ArchivesofPhysiologyandBiochemistry, 128, 666-678. https://doi.org/10.1080/13813455.2020.1716020
[2]
Sani, A., Tajik, A., Seiiedi, S.S., Khadem, R., Tootooni, H., Taherynejad, M., et al. (2022) A Review of the Anti-Diabetic Potential of Saffron. NutritionandMetabolicInsights, 15, 1-12. https://doi.org/10.1177/11786388221095223
[3]
Moshiri, M., Vahabzadeh, M. and Hosseinzadeh, H. (2014) Clinical Applications of Saffron (Crocus sativus) and Its Constituents: A Review. DrugResearch, 65, 287-295. https://doi.org/10.1055/s-0034-1375681
[4]
Liu, J., Yang, Y. and Qi, Y. (2024) Effect of Saffron Supplementation on the Glycemic Outcomes in Diabetes: A Systematic Review and Meta-Analysis. FrontiersinNutrition, 11, Article 1349006. https://doi.org/10.3389/fnut.2024.1349006
[5]
Giannoulaki, P., Kotzakioulafi, E., Nakas, A., Kontoninas, Z., Karlafti, E., Evripidou, P., et al. (2024) Effect of Crocus sativus Extract Supplementation in the Metabolic Control of People with Diabetes Mellitus Type 1: A Double-Blind Randomized Placebo-Controlled Trial. Nutrients, 16, Article 2089. https://doi.org/10.3390/nu16132089
[6]
Hooshmand Moghadam, B., Rashidlamir, A., Attarzadeh Hosseini, S.R., Gaeini, A.A. and Kaviani, M. (2022) The Effects of Saffron (Crocus sativusL.) in Conjunction with Concurrent Training on Body Composition, Glycaemic Status, and Inflammatory Markers in Obese Men with Type 2 Diabetes Mellitus: A Randomized Double‐blind Clinical Trial. BritishJournalofClinicalPharmacology, 88, 3256-3271. https://doi.org/10.1111/bcp.15222
[7]
Karimi-Nazari, E., Nadjarzadeh, A., Masoumi, R., Marzban, A., Mohajeri, S.A., Ramezani-Jolfaie, N., et al. (2019) Effect of Saffron (Crocus sativus L.) on Lipid Profile, Glycemic Indices and Antioxidant Status among Overweight/Obese Prediabetic Individuals: A Double-Blinded, Randomized Controlled Trial. ClinicalNutritionESPEN, 34, 130-136. https://doi.org/10.1016/j.clnesp.2019.07.012
[8]
Heshmati, J., Morvaridzadeh, M., Sepidarkish, M., Fazelian, S., Rahimlou, M., Omidi, A., et al. (2020) Effects of Melissa officinalis (lemon Balm) on Cardio‐metabolic Outcomes: A Systematic Review and Meta-Analysis. PhytotherapyResearch, 34, 3113-3123. https://doi.org/10.1002/ptr.6744
[9]
Sadigi, B., Yarani, R., Travica, N., Yousefi, Z., Shakouri, S. K., Ostadrahimi, A., Mobasseri, M., Tahmasbi, F., Sanaie, S., & Araj-Khodaei, M. (2023). Anti-Diabetic Properties of Melissa officinalis and Saffron: Recent Advances and Discoveries. Gazi Medical Journal, 34, 460-465. https://doi.org/10.12996/gmj.2023.93
[10]
Jandaghi, P., Noroozi, M., Ardalani, H. and Alipour, M. (2016) Lemon Balm: A Promising Herbal Therapy for Patients with Borderline Hyperlipidemia—A Randomized Double-Blind Placebo-Controlled Clinical Trial. ComplementaryTherapiesinMedicine, 26, 136-140. https://doi.org/10.1016/j.ctim.2016.03.012
[11]
Rajabi, A., Akbar Nezhad Gharehlo, A., Madadizadeh, E., Basereh, A., Khoramipoor, K., Pirani, H., et al. (2024) The Effect of 12 Weeks of Aerobic Exercise Training with or without Saffron Supplementation on Diabetes-Specific Markers and Inflammation in Women with Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Trial. EuropeanJournalofSportScience, 24, 899-906. https://doi.org/10.1002/ejsc.12125
[12]
Sadighi, B., Yarani, R., Taheri-Targhi, S., Sanaie, S., Shakouri, S.K., Mobasseri, M., et al. (2024) Effect of Saffron and Melissa officinalis L. Supplementation on Glycemic Parameters and Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial. InternationalJournalofDrugResearchinClinics, 2, e21. https://doi.org/10.34172/ijdrc.2024.e21
[13]
Petrisor, G., Motelica, L., Craciun, L.N., Oprea, O.C., Ficai, D. and Ficai, A. (2022) Melissa officinalis: Composition, Pharmacological Effects and Derived Release Systems—A Review. InternationalJournalofMolecularSciences, 23, Article 3591. https://doi.org/10.3390/ijms23073591
[14]
Costin, A.D., Cionca, I., Horga, V., Hulujan, I. and Suciu, D. (2024) Current Scientific Insights on the Antioxidant Effects of Melissa officinalis Extracts. HopandMedicinalPlants, 32, 236-242. https://doi.org/10.15835/hpm.v32i1-2.15028
[15]
Abdellatif, F., Akram, M., Begaa, S., Messaoudi, M., Benarfa, A., Egbuna, C., et al. (2021) Minerals, Essential Oils, and Biological Properties of Melissa officinalis L. Plants, 10, Article 1066. https://doi.org/10.3390/plants10061066
[16]
Ghaffari, S. and Roshanravan, N. (2019) Saffron; an Updated Review on Biological Properties with Special Focus on Cardiovascular Effects. Biomedicine&Pharmacotherapy, 109, 21-27. https://doi.org/10.1016/j.biopha.2018.10.031
[17]
Kosar, M., Demirci, B., Goger, F., Kara, I. and Baser, K.H.C. (2017) Volatile Composition, Antioxidant Activity, and Antioxidant Components in Saffron Cultivated in Türkiye. InternationalJournalofFoodProperties, 20, S746-S754. https://doi.org/10.1080/10942912.2017.1311341
[18]
Christodoulou, E., Kadoglou, N.P., Kostomitsopoulos, N. and Valsami, G. (2015) Saffron: A Natural Product with Potential Pharmaceutical Applications. JournalofPharmacyandPharmacology, 67, 1634-1649. https://doi.org/10.1111/jphp.12456
[19]
Djazayeri, A., Akhondzadeh, S., Milajerdi, A., Jazayeri, S., Hashemzadeh, N., Shirzadi, E., et al. (2018) The Effect of Saffron (Crocus sativus L.) Hydroalcoholic Extract on Metabolic Control in Type 2 Diabetes Mellitus: A Triple-Blinded Randomized Clinical Trial. JournalofResearchinMedicalSciences, 23, 16. https://doi.org/10.4103/jrms.jrms_286_17
[20]
Asadi, A., Shidfar, F., Safari, M., Hosseini, A.F., Fallah Huseini, H., Heidari, I., et al. (2018) Efficacy of Melissa officinalis L. (Lemon Balm) Extract on Glycemic Control and Cardiovascular Risk Factors in Individuals with Type 2 Diabetes: A Randomized, Double-Blind, Clinical Trial. PhytotherapyResearch, 33, 651-659. https://doi.org/10.1002/ptr.6254
[21]
Nayebi, N., Esteghamati, A., Meysamie, A., Khalili, N., Kamalinejad, M., Emtiazy, M., et al. (2019) The Effects of a Melissa officinalis L. Based Product on Metabolic Parameters in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blinded Controlled Clinical Trial. JournalofComplementaryandIntegrativeMedicine, 16, Article ID: 20180088. https://doi.org/10.1515/jcim-2018-0088
[22]
Moravej Aleali, A., Amani, R., Shahbazian, H., Namjooyan, F., Latifi, S.M. and Cheraghian, B. (2019) The Effect of Hydroalcoholic Saffron (Crocus sativus L.) Extract on Fasting Plasma Glucose, HbA1c, Lipid Profile, Liver, and Renal Function Tests in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial. PhytotherapyResearch, 33, 1648-1657. https://doi.org/10.1002/ptr.6351
[23]
Mobasseri, M., Ostadrahimi, A., Tajaddini, A., Asghari, S., Barati, M., Akbarzadeh, M., et al. (2020) Effects of Saffron Supplementation on Glycemia and Inflammation in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Trial Study. Diabetes&MetabolicSyndrome: ClinicalResearch&Reviews, 14, 527-534. https://doi.org/10.1016/j.dsx.2020.04.031
[24]
Tajaddini, A., Roshanravan, N., Mobasseri, M., Aeinehchi, A., Sefid‐Mooye Azar, P., Hadi, A., et al. (2021) Saffron Improves Life and Sleep Quality, Glycaemic Status, Lipid Profile and Liver Function in Diabetic Patients: A Double-Blind, Placebo-Controlled, Randomised Clinical Trial. InternationalJournalofClinicalPractice, 75, e14334. https://doi.org/10.1111/ijcp.14334
[25]
Kotanidou, E.P., Tsinopoulou, V.R., Giza, S., Ntouma, S., Angeli, C., Chatziandreou, M., et al. (2023) The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial. Children, 10, Article 1814. https://doi.org/10.3390/children10111814
[26]
Ebrahimi, F., Sahebkar, A., Aryaeian, N., Pahlavani, N., Fallah, S., Moradi, N., et al. (2019) Effects of Saffron Supplementation on Inflammation and Metabolic Responses in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. Diabetes, MetabolicSyndromeandObesity: TargetsandTherapy, 12, 2107-2115. https://doi.org/10.2147/dmso.s216666
[27]
Zhang, Y., Gan, R., Li, S., Zhou, Y., Li, A., Xu, D., et al. (2015) Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules, 20, 21138-21156. https://doi.org/10.3390/molecules201219753
