Ⅱ期结直肠癌手术患者脉管癌栓阳性与临床病理特征及预后的相关性
Correlation between Positive Vascular-Lymphatic Invasion and Clinicopathological Characteristics and Prognosis in Stage II Colorectal Cancer Patients Undergoing Surgery

目的：分析II期结直肠癌手术患者脉管癌栓阳性与临床病理特征及预后的相关性。方法：对86例结直肠癌手术患者的临床病理特征进行分析，通过骨转移后化疗情况、分化程度、首诊临床分期、手术情况等多因素对疾病进展进行多因素分析。结果：结直肠癌骨转移的临床特点表明，肿瘤部位、首诊临床分期、分化程度、骨转移前化疗、术前术后放疗和手术情况均对患者的平均进展时间有显著影响。且结直肠癌骨转移预后的多因素分析结果显示，ECOC评分和骨转移后化疗对疾病的预后有显著影响。结论：II期结直肠癌手术患者脉管癌栓阳性与多项临床病理特征相关，同时，骨转移后化疗是影响预后的主要因素。
Objective: To analyze the correlation between positive vascular-lymphatic invasion and clinicopathological characteristics and prognosis in stage II colorectal cancer patients undergoing surgery. Methods: The clinicopathological characteristics of 86 colorectal cancer surgery patients were analyzed. Multivariate analysis of disease progression was performed using multiple factors, including chemotherapy after bone metastasis, degree of differentiation, initial clinical stage, and surgical conditions. Results: Clinical characteristics of bone metastasis in colorectal cancer showed that tumor location, initial clinical stage, degree of differentiation, chemotherapy before bone metastasis, pre- and post-operative radiotherapy, and surgical conditions significantly influenced the average progression time. Multivariate analysis of prognosis for bone metastasis in colorectal cancer revealed that ECOG score and chemotherapy after bone metastasis significantly affected disease prognosis. Conclusion: Positive vascular-lymphatic invasion in stage II colorectal cancer surgery patients is correlated with multiple clinicopathological characteristics. Meanwhile, chemotherapy after bone metastasis is a major factor affecting prognosis.