|
|
胃腺癌手指指骨转移1例并文献复习
|
Abstract:
胃癌是消化系统常见的恶性肿瘤，常见骨转移包括脊柱、骨盆、肋骨，但手指指骨转移是一种极为罕见的临床表现。目前已知3例发表的胃癌转移至手指指骨病例。本文报道1例62岁男性患者，发现左手中指末端疼痛红肿，手指皮肤完好，结合影像学表现及患者胃癌病史，考虑胃癌骨转移可能性大，结合病理，最终诊断为胃腺癌指骨转移。通过对本病例介绍，对于胃癌患者，肢体远端出现疼痛、红肿时，特别是影像学出现肢体远端骨质破坏时，即使是罕见部位亦需考虑转移可能。
Gastric cancer is a common malignant tumor of the digestive system, and common bone metastases include the spine, pelvis, and ribs, but finger phalanx metastasis is an extremely rare clinical manifestation. At present, 3 published cases of gastric cancer metastasis to the finger phalanges are known. Combined with the imaging manifestations and the patient’s history of gastric cancer, it was considered that the possibility of gastric cancer bone metastasis was high, and combined with pathology, gastric adenocarcinoma was finally diagnosed with metastasis of the finger bone. Through the introduction of this case, for gastric cancer patients, when there is pain, redness and swelling in the distal limb, especially when the distal limb bone destruction occurs on imaging, even rare sites need to be considered for metastasis.
| [1] | Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. https://doi.org/10.3322/caac.21834 |
| [2] | Turkoz, F.P., Solak, M., Kilickap, S., et al. (2014) Bone Metastasis from Gastric Cancer: The Incidence, Clinicopathological Features, and Influence on Survival. Journal of Gastric Cancer, 14, 164-172. https://doi.org/10.5230/jgc.2014.14.3.164 |
| [3] | Hamdard, J., Bilici, A., Sakin, A., et al. (2024) Characteristic Features and Prognostic Factors in Gastric Cancer Patients with Bone Metastases: Multicenter Experience. Journal of Chemotherapy, 37, 268-277. |
| [4] | Wen, L., Li, Y., Zhang, J., Zhou, C., Yang, H., Chen, X., et al. (2019) Clinical Analysis of Bone Metastasis of Gastric Cancer: Incidence, Clinicopathological Features and Survival. Future Oncology, 15, 2241-2249. https://doi.org/10.2217/fon-2019-0039 |
| [5] | Qiu, M., Shi, S., Chen, Z., Yu, H., Sheng, H., Jin, Y., et al. (2018) Frequency and Clinicopathological Features of Metastasis to Liver, Lung, Bone, and Brain from Gastric Cancer: A Seer‐Based Study. Cancer Medicine, 7, 3662-3672. https://doi.org/10.1002/cam4.1661 |
| [6] | Nishidoi, H. and Koga, S. (1987) Clinicopathological Study of Gastric Cancer with Bone Metastasis. Gan to kagaku ryoho Cancer & chemotherapy, 14, 1717-1722. |
| [7] | Kerin, R. (1987) The Hand in Metastatic Disease. The Journal of Hand Surgery, 12, 77-83. https://doi.org/10.1016/s0363-5023(87)80164-8 |
| [8] | Harris, H., Khan, M. and Jaunoo, S. (2020) Distal Phalanx: An Unusual Site for a Gastric Adenocarcinoma Metastasis. BMJ Case Reports, 13, e236259. https://doi.org/10.1136/bcr-2020-236259 |
| [9] | Bahk, W., Rhee, S., Kang, Y., Lee, A., Park, J. and Chung, Y. (2005) Gastric Cancer Acrometastases to All Digits of One Hand Following Closed Intramedullary Nailing. Skeletal Radiology, 35, 529-532. https://doi.org/10.1007/s00256-005-0047-3 |
| [10] | Spiteri, V., Bibra, A., Ashwood, N. and Cobb, J. (2008) Managing Acrometastases Treatment Strategy with a Case Illustration. Annals of The Royal College of Surgeons of England, 90, 8-11. https://doi.org/10.1308/147870808x303137 |
| [11] | Bussard, K.M., Gay, C.V. and Mastro, A.M. (2007) The Bone Microenvironment in Metastasis; What Is Special about Bone? Cancer and Metastasis Reviews, 27, 41-55. https://doi.org/10.1007/s10555-007-9109-4 |
| [12] | Afshar, A., Farhadnia, P. and Khalkhali, H. (2014) Metastases to the Hand and Wrist: An Analysis of 221 Cases. The Journal of Hand Surgery, 39, 923-932.e17. https://doi.org/10.1016/j.jhsa.2014.01.016 |
| [13] | Hasegawa, K., Pereira, B.P. and Pho, R.W.H. (2001) The Microvasculature of the Nail Bed, Nail Matrix, and Nail Fold of a Normal Human Fingertip. The Journal of Hand Surgery, 26, 283-290. https://doi.org/10.1053/jhsu.2001.21519 |
| [14] | Hsieh, H. and Tsai, M. (2019) Tumor Progression-Dependent Angiogenesis in Gastric Cancer and Its Potential Application. World Journal of Gastrointestinal Oncology, 11, 686-704. https://doi.org/10.4251/wjgo.v11.i9.686 |
| [15] | Isowa, S., Shimo, T., Ibaragi, S., et al. (2010) PTHrP Regulates Angiogenesis and Bone Resorption via VEGF Expression. Anticancer Research, 30, 2755-2767. |
| [16] | Ammendola, M., Marech, I., Sammarco, G., Zuccalà, V., Luposella, M., Zizzo, N., et al. (2015) Infiltrating Mast Cells Correlate with Angiogenesis in Bone Metastases from Gastric Cancer Patients. International Journal of Molecular Sciences, 16, 3237-3250. https://doi.org/10.3390/ijms16023237 |
| [17] | Joll, C.A. (1923) Metastatic Tumours of Bone. Journal of British Surgery, 11, 38-72. https://doi.org/10.1002/bjs.1800114105 |
| [18] | Tolo, E.T., Cooney, W.P. and Wenger, D.E. (2002) Renal Cell Carcinoma with Metastases to the Triquetrum: Case Report. The Journal of Hand Surgery, 27, 876-881. https://doi.org/10.1053/jhsu.2002.34368 |
| [19] | Unsworth, R., Hirst, J.T., Adam, C.L., et al. (2024) The Dog Bite, the Acrometastasis and the Disappearing Hamate. Cureus, 16, e57246. |
| [20] | van Veenendaal, L.M., de Klerk, G. and Velde, D.V.D. (2014) A Painful Finger as First Sign of a Malignancy. Geriatric Orthopaedic Surgery & Rehabilitation, 5, 18-20. https://doi.org/10.1177/2151458514522125 |
