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Bioprocess 2025
Atl2 (Atlastin-2)在细胞中的功能及其作用机制
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Abstract:
Atl2 (Atlastin-2)是一种重要的跨膜GTP酶，作为Atlastin蛋白家族成员之一，参与多种细胞生物学过程。研究表明Atl2与细胞器正常形态和功能的维持密切相关，例如内质网、高尔基体、脂滴等。本文综述了Atl2的结构及其生物学特性，重点阐述了Atl2在细胞膜融合、高尔基体形态稳定、内质网自噬调控和脂滴合成的作用，同时阐述了其在细胞器稳态及部分疾病中的作用。可见Atl2作为潜在治疗靶点是一个具有应用前景的研究方向，因此本文综述为进一步探索Atl2的功能与机制提供了较全面的研究基础和思路。
Atlastin-2 (Atl2), a critical transmembrane GTPase and member of the Atlastin protein family, participates in diverse cellular biological processes. Studies indicate that Atl2 plays a crucial role in maintaining the morphology and function of organelles, including the endoplasmic reticulum, Golgi apparatus, and lipid droplets. This paper reviews the structure and biological characteristics of Atl2, with a focus on elucidating its roles in cell membrane fusion, Golgi apparatus morphology maintenance, endoplasmic reticulum autophagy regulation, and lipid droplet synthesis. It also discusses the function of Atl2 in organelle homeostasis and its involvement in certain diseases. This review provides a comprehensive foundation and conceptual framework for further exploration of Atl2’s functions and mechanisms.
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