Objective: To observe the clinical efficacy of intra-articular injection of platelet-rich plasma (PRP) in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Method: Sixty patients were divided into an experimental group and a control group. The experimental group was injected with betamethasone sodium phosphate 5.26 mg combined with PRP3 ml in the knee joint cavity for the first time, and then injected with PRP once a week for a total of 4 times. In the control group, a betamethasone sodium phosphate injection of 5.26 mg combined with a sodium hyaluronate injection of 2 ml was injected into the knee joint cavity for the first time, and then sodium hyaluronate injection was injected weekly for a total of 4 times. All patients were followed up for 3 months after treatment. The levels of serum inflammatory factors [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR)] before and after treatment were compared between the two groups. The scores of the osteoarthritis index scale (WOMAC), visual analogue scale (VAS) and Lysholm knee score (LKS) were compared before and 1 and 3 months after treatment. Results: After treatment, the levels of serum CRP and ESR in the two groups were lower than those before treatment, and those in the experimental group were lower than those in the control group (P < 0.05). After 1 month and 3 months of treatment, the WOMAC and VAS scores of the two groups were lower than those before treatment, the LKS score was higher than that before treatment, and the WOMAC and VAS scores of the experimental group were lower than those of the control group, and the LKS score was higher than that of the control group (P < 0.05). Conclusion: Intra-articular injection of PRP is effective in the treatment of RA patients with knee osteoarthritis, which can significantly regulate the levels of inflammatory factors, improve knee joint function, and relieve pain.
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