Standard reference values for pre- and post-ductal oxygen saturation within the 1st 24 hours of life are essential for comparison and early detection of deviations from the norm. Such data is sparse in Nigeria. We determined the reference values for pre-ductal and post-ductal oxygen saturation by pulse oximetry during the first 24 hours of life in apparently healthy term infants in Makurdi, a city at an altitude of 113 m above sea level in North Central Nigeria. This study was cross-sectional and eligible neonates with birth weights ≥ 1500 g were consecutively enrolled. Pre- and post-ductal pulse oximetry readings were obtained using a Lifebox oximeter？. Four hundred and six neonates (91% normal weight, 6% LBW, and 3% macrosomic) were studied. Although the mean pre- and post-ductal oxygen saturation were found to differ significantly; 97.41% ± 1.52% and 96.66% ± 1.95% respectively (paired sample t = 8.359, p < 0.001) and these progressively increased with both increases in weight and age in hours although not statistically significant.
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