Background: Low-dose CT provides essential diagnostic information while minimizing radiation exposure through few-view reconstruction techniques. However, these techniques often introduce noise and artifacts, affecting diagnostic accuracy. Although
-smoothing regularization methods partially address these issues, their fixed sparsity constraint cannot adapt to CT image complex characteristics, and they remain highly sensitive to regularization parameter selection. Objective: To propose a novel CT image denoising method named Variable Step Normalized Least Mean Square
-smoothing (VSNLMS-
) that achieves an optimal balance between noise reduction and structural preservation while reducing sensitivity to regularization parameter selection. Methods: The VSNLMS-
method employs an adaptive framework that dynamically responds to local image characteristics. The variable step-size strategy enables precise calibration of processing intensity across regions with varying noise levels and detail complexity, ingeniously combining filtered back projection (FBP) reconstruction results with
-smoothing to create a composite desired signal. Conclusions: This approach offers an effective solution for enhancing low-dose CT image quality and improving diagnostic reliability.
References
[1]
Tang, L., Hui, Y., Yang, H., Zhao, Y. and Tian, C. (2022) Medical Image Fusion Quality Assessment Based on Conditional Generative Adversarial Network. FrontiersinNeuroscience, 16, Article 986153. https://doi.org/10.3389/fnins.2022.986153
[2]
Wang, T., Chen, C., Shen, K., Liu, W. and Tian, C. (2023) Streak Artifact Suppressed Back Projection for Sparse-View Photoacoustic Computed Tomography. AppliedOptics, 62, 3917-3925. https://doi.org/10.1364/ao.487957
[3]
Balda, M., Hornegger, J. and Heismann, B. (2012) Ray Contribution Masks for Structure Adaptive Sinogram Filtering. IEEETransactionsonMedicalImaging, 31, 1228-1239. https://doi.org/10.1109/tmi.2012.2187213
[4]
Manduca, A., Yu, L., Trzasko, J.D., Khaylova, N., Kofler, J.M., McCollough, C.M., etal. (2009) Projection Space Denoising with Bilateral Filtering and CT Noise Modeling for Dose Reduction in Ct. MedicalPhysics, 36, 4911-4919. https://doi.org/10.1118/1.3232004
[5]
Wang, T., Kudo, H., Yamazaki, F. and Liu, H. (2019) A Fast Regularized Iterative Algorithm for Fan-Beam CT Reconstruction. PhysicsinMedicine&Biology, 64, Article 145006. https://doi.org/10.1088/1361-6560/ab22ed
[6]
Wang, S., Wu, W., Feng, J., Liu, F. and Yu, H. (2020) Low-Dose Spectral CT Reconstruction Based on Image-Gradient L0-Norm and Adaptive Spectral PICCS. PhysicsinMedicine&Biology, 65, Article 245005. https://doi.org/10.1088/1361-6560/aba7cf
[7]
Chen, Z., Jin, X., Li, L. and Wang, G. (2013) A Limited-Angle CT Reconstruction Method Based on Anisotropic TV Minimization. Physics in Medicine and Biology, 58, 2119-2141. https://doi.org/10.1088/0031-9155/58/7/2119
[8]
Xia, W., Yang, Z., Lu, Z., Wang, Z. and Zhang, Y. (2024) RegFormer: A Local-Nonlocal Regularization-Based Model for Sparse-View CT Reconstruction. IEEE Transactions on Radiation and Plasma Medical Sciences, 8, 184-194. https://doi.org/10.1109/trpms.2023.3281148
[9]
Yu, H., Wang, S., Wu, W., Gong, C., Wang, L., Pi, Z., et al. (2021) Weighted Adaptive Non-Local Dictionary for Low-Dose CT Reconstruction. Signal Processing, 180, Article 107871. https://doi.org/10.1016/j.sigpro.2020.107871
[10]
Wu, D., Kim, K., El Fakhri, G. and Li, Q. (2017) Iterative Low-Dose CT Reconstruction with Priors Trained by Artificial Neural Network. IEEE Transactions on Medical Imaging, 36, 2479-2486. https://doi.org/10.1109/tmi.2017.2753138
Mallat, S. and Hwang, W.L. (1992) Singularity Detection and Processing with Wavelets. IEEETransactionsonInformationTheory, 38, 617-643. https://doi.org/10.1109/18.119727
[13]
Rudin, L.I., Osher, S. and Fatemi, E. (1992) Nonlinear Total Variation Based Noise Removal Algorithms. PhysicaD:NonlinearPhenomena, 60, 259-268. https://doi.org/10.1016/0167-2789(92)90242-f
[14]
Dabov, K., Foi, A., Katkovnik, V. and Egiazarian, K. (2007) Image Denoising by Sparse 3-D Transform-Domain Collaborative Filtering. IEEETransactionsonImageProcessing, 16, 2080-2095. https://doi.org/10.1109/tip.2007.901238
[15]
Xu, L., Lu, C., Xu, Y. and Jia, J. (2011) Image Smoothing via L0 Gradient Minimization. ACMTransactionsonGraphics, 30, 1-12. https://doi.org/10.1145/2070781.2024208
[16]
Zheng, A., Gao, H., Zhang, L. and Xing, Y. (2020) A Dual-Domain Deep Learning-Based Reconstruction Method for Fully 3D Sparse Data Helical CT. PhysicsinMedicine&Biology, 65, 245030. https://doi.org/10.1088/1361-6560/ab8fc1
[17]
Kang, E., Min, J. and Ye, J.C. (2017) A Deep Convolutional Neural Network Using Directional Wavelets for Low‐Dose X‐Ray CT Reconstruction. MedicalPhysics, 44, e360-e375. https://doi.org/10.1002/mp.12344
[18]
Wu, D., Kim, K. and Li, Q. (2019) Computationally Efficient Deep Neural Network for Computed Tomography Image Reconstruction. MedicalPhysics, 46, 4763-4776. https://doi.org/10.1002/mp.13627
[19]
Bao, P., Sun, H., Wang, Z., Zhang, Y., Xia, W., Yang, K., etal. (2019) Convolutional Sparse Coding for Compressed Sensing CT Reconstruction. IEEETransactionsonMedicalImaging, 38, 2607-2619. https://doi.org/10.1109/tmi.2019.2906853
[20]
Lu, W., Onofrey, J.A., Lu, Y., Shi, L., Ma, T., Liu, Y., etal. (2019) An Investigation of Quantitative Accuracy for Deep Learning Based Denoising in Oncological Pet. PhysicsinMedicine&Biology, 64, Article 165019. https://doi.org/10.1088/1361-6560/ab3242
[21]
Yang, Q., Yan, P., Zhang, Y., Yu, H., Shi, Y., Mou, X., etal. (2018) Low-Dose CT Image Denoising Using a Generative Adversarial Network with Wasserstein Distance and Perceptual Loss. IEEETransactionsonMedicalImaging, 37, 1348-1357. https://doi.org/10.1109/tmi.2018.2827462
[22]
Dong, X., Lei, Y., Wang, T., Higgins, K., Liu, T., Curran, W.J., etal. (2020) Deep Learning-Based Attenuation Correction in the Absence of Structural Information for Whole-Body Positron Emission Tomography Imaging. PhysicsinMedicine&Biology, 65, Article 055011. https://doi.org/10.1088/1361-6560/ab652c
[23]
Corda-D’Incan, G., Schnabel, J.A. and Reader, A.J. (2022) Memory-Efficient Training for Fully Unrolled Deep Learned PET Image Reconstruction with Iteration-Dependent Targets. IEEETransactionsonRadiationandPlasmaMedicalSciences, 6, 552-563. https://doi.org/10.1109/trpms.2021.3101947
[24]
Slock, D.T.M. (1993) On the Convergence Behavior of the LMS and the Normalized LMS Algorithms. IEEETransactionsonSignalProcessing, 41, 2811-2825. https://doi.org/10.1109/78.236504
[25]
Eweda, E., Bershad, N.J. and Bermudez, J.C.M. (2018) Stochastic Analysis of the LMS and NLMS Algorithms for Cyclostationary White Gaussian and Non-Gaussian Inputs. IEEETransactionsonSignalProcessing, 66, 4753-4765. https://doi.org/10.1109/tsp.2018.2860552
[26]
Setiadi, D.R.I.M. (2020) PSNR vs SSIM: Imperceptibility Quality Assessment for Image Steganography. MultimediaToolsandApplications, 80, 8423-8444. https://doi.org/10.1007/s11042-020-10035-z