|
|
细胞因子谱与重症肺炎相关研究进展
|
Abstract:
本综述聚焦细胞因子谱与重症肺炎的多方面研究。首先阐述细胞因子在重症肺炎中的病理机制、重症肺炎流行病学特征及细胞因子谱的历史演变与研究进展。接着探讨常规检验指标在重症肺炎中的诊断价值、现状及未来发展方向，以及细胞因子谱与常规检验指标的联合应用，包括联合诊断策略、在预后评估中的作用及临床实践与技术进展。同时介绍重症肺炎诊断技术的最新进展，治疗策略的演变，并分析细胞因子谱与常规检验指标在应用中的争议点。旨在全面梳理该领域研究，为重症肺炎的诊治提供理论依据与研究方向。
This review focuses on multifaceted research regarding cytokine profiles and severe pneumonia. First, it elaborates on the pathological mechanisms of cytokines in severe pneumonia, the epidemiological characteristics of severe pneumonia, and the historical evolution and research progress of cytokine profiling. Subsequently, it explores the diagnostic value, current status, and future directions of conventional laboratory markers in severe pneumonia, as well as the combined application of cytokine profiles and conventional biomarkers—including integrated diagnostic strategies, their role in prognostic evaluation, and clinical practice alongside technological advancements. Additionally, it highlights the latest progress in diagnostic techniques for severe pneumonia and the evolution of treatment strategies, while analyzing controversies in the application of cytokine profiles and conventional biomarkers. The review aims to comprehensively synthesize research in this field, providing a theoretical foundation and future directions for the diagnosis and treatment of severe pneumonia.
| [1] | Dukhinova, M., Kokinos, E., Kuchur, P., Komissarov, A. and Shtro, A. (2021) Macrophage-Derived Cytokines in Pneumonia: Linking Cellular Immunology and Genetics. Cytokine & Growth Factor Reviews, 59, 46-61. https://doi.org/10.1016/j.cytogfr.2020.11.003 |
| [2] | Uematsu, T., Fujita, T., Nakaoka, H.J., Hara, T., Kobayashi, N., Murakami, Y., et al. (2016) Mint3/Apba3 Depletion Ameliorates Severe Murine Influenza Pneumonia and Macrophage Cytokine Production in Response to the Influenza Virus. Scientific Reports, 6, Article No. 37815. https://doi.org/10.1038/srep37815 |
| [3] | Hakim, N.N., Chi, J., Olazagasti, C. and Liu, J.M. (2020) Secondary Hemophagocytic lymphohistiocytosis versus Cytokine Release Syndrome in Severe COVID-19 Patients. Experimental Biology and Medicine, 246, 5-9. https://doi.org/10.1177/1535370220962043 |
| [4] | Ma, L., Yan, J., Song, W., Wu, B., Wang, Z. and Xu, W. (2023) Early Peripheral Blood Lymphocyte Subsets and Cytokines in Predicting the Severity of Influenza B Virus Pneumonia in Children. Frontiers in Cellular and Infection Microbiology, 13, Article 1173362. https://doi.org/10.3389/fcimb.2023.1173362 |
| [5] | Ma, R., Liu, Z., Zhang, L., Chen, C., Yuan, B., Luo, Y., et al. (2024) Epidemiological Characteristics of Severe Community-Acquired Pneumonia in Children Admitted to Two Tertiary Hospitals in Shihezi, Xinjiang Region, China in 2023: A Cross-Sectional Analysis. Journal of Thoracic Disease, 16, 6969-6982. https://doi.org/10.21037/jtd-24-1417 |
| [6] | Zhang, Z.X.Z., Mar Kyaw, W., Ho, H.J., Tay, M.Z., Huang, H., Aung Hein, A., et al. (2019) Seasonal Influenza-Associated Intensive Care Unit Admission and Death in Tropical Singapore, 2011-2015. Journal of Clinical Virology, 117, 73-79. https://doi.org/10.1016/j.jcv.2019.06.005 |
| [7] | Ni, Y.Y., Zhong, H.H., Gu, Y., et al. (2023) Clinical Features, Treatment, and Outcome of Psittacosis Pneumonia: A Multicenter Study. Open Forum Infectious Diseases, 10, ofac518. |
| [8] | Yamamoto, D., Okamoto, M., Lupisan, S., Suzuki, A., Saito, M., Tamaki, R., et al. (2014) Impact of Human Adenovirus Serotype 7 in Hospitalized Children with Severe Fatal Pneumonia in the Philippines. Japanese Journal of Infectious Diseases, 67, 105-110. https://doi.org/10.7883/yoken.67.105 |
| [9] | Kalvakolanu, D.V. (2017) Twenty Five Years of Cytokine: On a Forward Path to Exciting Discoveries of Pathological Mechanisms and Therapeutics. Cytokine, 98, 1-3. https://doi.org/10.1016/j.cyto.2017.08.008 |
| [10] | Huang, L.L., Ye, C.Y., Zhou, R.X., et al. (2024) Diagnostic Value of Routine Blood Tests in Differentiating between SARS-CoV-2, Influenza A, and RSV Infections in Hospitalized Children: A Retrospective Study. BMC Pediatrics, 24, Article No. 328. |
| [11] | Zhu, F., Jiang, Z., Li, W.H., et al. (2015) Clinical Significance of Serum Procalcitonin Level Monitoring on Early Diagnosis of Severe Pneumonia on Children. European Review for Medical and Pharmacological Sciences, 19, 4300-4303. |
| [12] | Ferrer, M., Sequeira, T., Cilloniz, C., Dominedo, C., Li Bassi, G., Martin-Loeches, I., et al. (2019) Ventilator-Associated Pneumonia and PaO2/FiO2 Diagnostic Accuracy: Changing the Paradigm? Journal of Clinical Medicine, 8, Article 1217. https://doi.org/10.3390/jcm8081217 |
| [13] | Shan, J., Chen, H. and Zhu, J. (2011) Diagnostic Accuracy of Clinical Pulmonary Infection Score for Ventilator-Associated Pneumonia: A Meta-Analysis. Respiratory Care, 56, 1087-1094. https://doi.org/10.4187/respcare.01097 |
| [14] | Zhang, J., Ma, C., Du, Y., Huang, J. and Xue, L. (2025) Microfluidic Biosensors for Rapid Detection of Foodborne Pathogenic Bacteria: Recent Advances and Future Perspectives. Frontiers in Chemistry, 13, Article 1536928. https://doi.org/10.3389/fchem.2025.1536928 |
| [15] | Lin, X., Xu, E., Zhang, T., Zhu, Q., Liu, Y. and Tian, Q. (2025) Cytokine-Based Nomogram for Discriminating Viral Pneumonia from Mycoplasma Pneumoniae Pneumonia in Children. Diagnostic Microbiology and Infectious Disease, 111, Article 116611. https://doi.org/10.1016/j.diagmicrobio.2024.116611 |
| [16] | Wu, Y., Xu, S.J. and Xia, Y. (2025) Prognostic Value of Chest Computer Tomography Combined with Serum Platelet Count, C-Reactive Protein Levels and Oxygenation Index in Severe Community-Acquired Pneumonia. Pakistan Journal of Medical Sciences, 41, 554-558. |
| [17] | Shafiek, H.K., El Lateef, H.M.A., Boraey, N.F., Nashat, M., Abd-Elrehim, G.A.B., Abouzeid, H., et al. (2021) Cytokine Profile in Egyptian Children and Adolescents with COVID-19 Pneumonia: A Multicenter Study. Pediatric Pulmonology, 56, 3924-3933. https://doi.org/10.1002/ppul.25679 |
| [18] | Ren, Y., Zhou, B., Yu, M., Xue, Y., Kong, W. and Yang, R. (2025) Label-Free Differential Chemiluminescent Immunosensor Based on Magnetic Nanoparticles CuFe2O4@abei-Gnps with Dual Catalytic Sites. Analytica Chimica Acta, 1333, Article 343397. https://doi.org/10.1016/j.aca.2024.343397 |
| [19] | Machleid, R., Nunna, S., George, A., Austerjost, J., Tomala, M. and Surowiec, I. (2025) Real-Time VCC Monitoring and Forecasting in Hek-Cell-Based Raav Vector Production Using Capacitance Spectroscopy. Engineering in Life Sciences, 25, e70004. https://doi.org/10.1002/elsc.70004 |
| [20] | Moaaz, E.M., Abdel-Moety, E.M., Rezk, M.R. and Fayed, A.S. (2024) An Eco-Friendly Smartphone Based HPTLC Method versus Conventional Densitometric One for Determination of Naltrexone and Bupropion. BMC Chemistry, 18, Article 185. https://doi.org/10.1186/s13065-024-01285-1 |
| [21] | Ngom, B., Guo, Y., Wang, X. and Bi, D. (2010) Development and Application of Lateral Flow Test Strip Technology for Detection of Infectious Agents and Chemical Contaminants: A Review. Analytical and Bioanalytical Chemistry, 397, 1113-1135. https://doi.org/10.1007/s00216-010-3661-4 |
| [22] | Frossard, L., Langton, C., Perevoshchikova, N., Feih, S., Powrie, R., Barrett, R., et al. (2023) Next-Generation Devices to Diagnose Residuum Health of Individuals Suffering from Limb Loss: A Narrative Review of Trends, Opportunities, and Challenges. Journal of Science and Medicine in Sport, 26, S22-S29. https://doi.org/10.1016/j.jsams.2023.02.004 |
| [23] | Kornitzky, F.W., Langen, H.J. and Held, M. (2021) Treatment of a Patient with a Pronounced Cytokine Storm in Severe COVID-19 Pneumonia Using a Hemoadsorption in Combination with the Administration of Tocilizumab. Pneumologie, 75, 644-650. |
| [24] | Heymann, E.P., Lim, R., Maskalyk, J., Pulfrey, S., Chun, S., Osei-Ampofo, M., et al. (2024) Emergency Medicine: A Global Perspective on Its Past, Evolution, and Future. Internal and Emergency Medicine. https://doi.org/10.1007/s11739-024-03812-3 |
| [25] | Kusirisin, P., Noppakun, K., Trongtrakul, K., Vongsanim, S., Suteeka, Y., Ophascharoensuk, V., et al. (2023) Efficacy of the Cytokine Adsorption Therapy in Patients with Severe Covid-19-Associated Pneumonia: Lesson Learned from a Prospective Observational Study. Blood Purification, 53, 10-22. https://doi.org/10.1159/000534914 |
| [26] | Higdon Melissa, M., Le Tham, O., Brien Katherine, L., et al. (2017) Association of C-Reactive Protein with Bacterial and Respiratory Syncytial Virus-Associated Pneumonia Among Children Aged<5 Years in the PERCH Study. Clinical Infectious Diseases, 64, S378-S386. |
| [27] | Ding, R., Chen, Z., He, M., Cen, H., Liu, Z. and Su, Y. (2022) Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3+ T Lymphocytes, and CEA in Colorectal Cancer Screening. Disease Markers, 2022, 1-7. https://doi.org/10.1155/2022/7913025 |
