生物信息学课程混合式教学探索：构建综合案例库与教学改革实践
Exploration of Blended Teaching in Bioinformatics Courses: TheConstruction of a Comprehensive Case Library and Practice of Teaching Reform

文章系统探讨了生物信息学课程中混合式教学模式的创新实践与成效评估。研究团队以构建综合案例库为核心教学载体，整合了单细胞数据分析、空间转录组数据分析等前沿领域的最新研究成果，实现了教学内容的前沿性与系统性的有机统一。文章从三个维度深入阐述了教学改革路径：首先，在教学内容方面，建立了动态更新机制；其次，在教学实施环节，开发了“案例库导向–小组协作–成果展示”的学习流程；最后，构建了包含过程性评价、项目成果评价和终期考核的多元考核体系。研究表明，这种基于案例库的混合式教学模式不仅显著提升了学生的实践创新能力，更培养了其跨学科思维和解决复杂生物信息学问题的综合素养，为新时代生物信息学人才培养提供了可复制的范式。
This paper systematically explores the innovative practice and effectiveness evaluation of the blended teaching model in bioinformatics courses. Taking the construction of a comprehensive case library as the core teaching carrier, the research team has integrated the latest research achievements in cutting-edge fields such as single-cell data analysis and spatial transcriptomics data analysis, achieving an organic unity of the frontier nature and systematicness of the teaching content. This paper elaborates on the teaching reform path from three dimensions. Firstly, in terms of teaching content, a dynamic update mechanism has been established. Secondly, in the teaching implementation stage, a learning process of “case library-oriented, group collaboration, and achievement presentation” has been developed. Finally, a diversified assessment system has been constructed, which includes formative evaluation, project achievement evaluation, and final assessment. The research shows that this blended teaching model based on the case library not only significantly enhances students’ practical and innovative abilities but also cultivates their interdisciplinary thinking and comprehensive literacy in solving complex bioinformatics problems, providing a replicable paradigm for the cultivation of bioinformatics talents in the new era.