Objective: To investigate the association between creatine kinase (CK), creatine kinase myocardial band (CK-MB), and osteoporotic fracture. Methods: The clinical data of 60 patients with osteoporotic fractures and 52 patients with normal physical examinations were analyzed retrospectively. The above individuals were set as an osteoporotic fracture group and a control group. Age, body mass index, serum C-reactive protein, CK and CK-MB between the two groups were compared. Analyses of the relationship between biochemical indexes and osteoporotic fractures were employed by Pearson correlation analysis, receiver operating characteristic curve (ROC) and multiple logistic regression model. Results: A higher level of age was found in the osteoporotic fracture group than in the control group, and lower levels of serum CK and CK-MB of the osteoporotic fracture group than in the control group were observed (P < 0.05, respectively). The age of the osteoporotic fracture group was significantly negatively correlated with CK and CK-MB (P < 0.05). After age adjustment, the CK and CK-MB were protective factors for osteoporotic fractures (P < 0.05). Conclusion: Lower levels of serum CK and CK-MB were found in osteoporotic fracture patients and were adversely linked with age. The serum CK and CK-MB may be new diagnostic indicators of osteoporotic fracture.
References
[1]
Ding, J., Zhang, C. and Guo, Y. (2021) The Association of OPG Polymorphisms with Risk of Osteoporotic Fractures: A Systematic Review and Meta-Analysis. Medicine, 100, e26716. https://doi.org/10.1097/md.0000000000026716
[2]
Akkawi, I. and Zmerly, H. (2018) Osteoporosis: Current Concepts. Joints, 6, 122-127. https://doi.org/10.1055/s-0038-1660790
[3]
Wang, P., Liu, L. and Lei, S. (2021) Causal Effects of Homocysteine Levels on the Changes of Bone Mineral Density and Risk for Bone Fracture: A Two-Sample Mendelian Randomization Study. Clinical Nutrition, 40, 1588-1595. https://doi.org/10.1016/j.clnu.2021.02.045
[4]
Shi, L., Min, N., Wang, F. and Xue, Q. (2019) Bisphosphonates for Secondary Prevention of Osteoporotic Fractures: A Bayesian Network Meta-Analysis of Randomized Controlled Trials. BioMed Research International, 2019, Article ID: 2594149. https://doi.org/10.1155/2019/2594149
[5]
Zhang, H., Hu, Y., Chen, X., Wang, S., Cao, L., Dong, S., et al. (2022) Expert Consensus on the Bone Repair Strategy for Osteoporotic Fractures in China. Frontiers in Endocrinology, 13, Article 989648. https://doi.org/10.3389/fendo.2022.989648
[6]
Dai, C., Liang, G., Zhang, Y., Dong, Y. and Zhou, X. (2022) Risk Factors of Vertebral Re-Fracture after PVP or PKP for Osteoporotic Vertebral Compression Fractures, Especially in Eastern Asia: A Systematic Review and Meta-analysis. Journal of Orthopaedic Surgery and Research, 17, Article No. 161. https://doi.org/10.1186/s13018-022-03038-z
[7]
Yang, Z., Zhang, W., Ren, X., Tu, C. and Li, Z. (2021) Exosomes: A Friend or Foe for Osteoporotic Fracture? Frontiers in Endocrinology, 12, Article 679914. https://doi.org/10.3389/fendo.2021.679914
[8]
Bermejo, I., Carnicero, J.A., Garcia, F.J., Pérez-Baos, S., Mateos, M., Medina, J.P., et al. (2022) POS1446 Creatine Kinase Could Be a Marker of Chronic Inflammation-Induced Sarcopenia in FRAIL Patients. Annals of the Rheumatic Diseases, 81, 1067-1068. https://doi.org/10.1136/annrheumdis-2022-eular.4571
[9]
Hong, C., Choi, S., Park, M., Park, S.M. and Lee, G. (2021) Body Composition and Osteoporotic Fracture Using Anthropometric Prediction Equations to Assess Muscle and Fat Masses. Journal of Cachexia, Sarcopenia and Muscle, 12, 2247-2258. https://doi.org/10.1002/jcsm.12850
[10]
Imamudeen, N., Basheer, A., Iqbal, A.M., Manjila, N., Haroon, N.N. and Manjila, S. (2022) Management of Osteoporosis and Spinal Fractures: Contemporary Guidelines and Evolving Paradigms. Clinical Medicine & Research, 20, 95-106. https://doi.org/10.3121/cmr.2021.1612
[11]
El-Hajj Fuleihan, G., Chakhtoura, M., Cauley, J.A. and Chamoun, N. (2017) Worldwide Fracture Prediction. Journal of Clinical Densitometry, 20, 397-424. https://doi.org/10.1016/j.jocd.2017.06.008
[12]
Mick, P. and Fischer, C. (2022) Delayed Fracture Healing. Seminars in Musculoskeletal Radiology, 26, 329-337. https://doi.org/10.1055/s-0041-1740380
[13]
Kanis, J.A., Harvey, N.C., McCloskey, E., et al. (2019) Algorithm for the Management of Patients at Low, High and Very High Risk of Osteoporotic Fractures. Osteoporosis International, 31, 1-12.
[14]
Qin, H. and Jiao, W. (2022) Correlation of Muscle Mass and Bone Mineral Density in the NHANES US General Population, 2017-2018. Medicine, 101, e30735. https://doi.org/10.1097/md.0000000000030735
[15]
Valerio, M.S., Janakiram, N.B., Goldman, S.M. and Dearth, C.L. (2020) Pleiotropic Actions of Vitamin D in Composite Musculoskeletal Trauma. Injury, 51, 2099-2109. https://doi.org/10.1016/j.injury.2020.06.023
[16]
Lara-Castillo, N. and Johnson, M.L. (2020) Bone-muscle Mutual Interactions. Current Osteoporosis Reports, 18, 408-421. https://doi.org/10.1007/s11914-020-00602-6
[17]
Lu, S., Chen, X., Chen, Q., Cahilog, Z., Hu, L., Chen, Y., et al. (2021) Effects of Dexmedetomidine on the Function of Distal Organs and Oxidative Stress after Lower Limb Ischaemia-Reperfusion in Elderly Patients Undergoing Unilateral Knee Arthroplasty. British Journal of Clinical Pharmacology, 87, 4212-4220. https://doi.org/10.1111/bcp.14830
[18]
Huang, T., Nosaka, K. and Chen, T.C. (2022) Changes in Blood Bone Markers after the First and Second Bouts of Whole-Body Eccentric Exercises. Scandinavian Journal of Medicine & Science in Sports, 32, 521-532. https://doi.org/10.1111/sms.14118
[19]
Keceli, G., Gupta, A., Sourdon, J., Gabr, R., Schär, M., Dey, S., et al. (2022) Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure. Circulation Research, 130, 741-759. https://doi.org/10.1161/circresaha.121.319648
[20]
Zwirner, J., Anders, S., Bohnert, S., Burkhardt, R., Da Broi, U., Hammer, N., et al. (2021) Screening for Fatal Traumatic Brain Injuries in Cerebrospinal Fluid Using Blood-Validated CK and CK-MB Immunoassays. Biomolecules, 11, Article 1061. https://doi.org/10.3390/biom11071061
[21]
Si, S., Li, J., Tewara, M.A. and Xue, F. (2021) Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study. Frontiers in Immunology, 12, Article 720876. https://doi.org/10.3389/fimmu.2021.720876
[22]
Jiang, C., Zhu, S., Zhan, W., Lou, L., Li, A. and Cai, J. (2024) Comparative Analysis of Bone Turnover Markers in Bone Marrow and Peripheral Blood: Implications for Osteoporosis. Journal of Orthopaedic Surgery and Research, 19, Article No. 163. https://doi.org/10.1186/s13018-024-04634-x
[23]
Zhang, Z. (2022) Chinese Society of Osteoporosis and Bone Mineral Research. Chinese General Practice.
[24]
Mobasseri, M., Tarverdizadeh, N., Mirghafourvand, M., Salehi-Pourmehr, H., Ostadrahimi, A. and Farshbaf-Khalili, A. (2023) The Role of Bone Turnover Markers in Screening Low Bone Mineral Density and Their Relationship with Fracture Risk in the Postmenopausal Period. Journal of Research in Medical Sciences, 28, Article 54. https://doi.org/10.4103/jrms.jrms_612_22
[25]
Haarhaus, M., Aaltonen, L., Cejka, D., Cozzolino, M., de Jong, R.T., D’Haese, P., et al. (2022) Management of Fracture Risk in CKD—Traditional and Novel Approaches. Clinical Kidney Journal, 16, 456-472. https://doi.org/10.1093/ckj/sfac230
[26]
Ciancia, S., van Rijn, R.R., Högler, W., Appelman-Dijkstra, N.M., Boot, A.M., Sas, T.C.J., et al. (2022) Osteoporosis in Children and Adolescents: When to Suspect and How to Diagnose It. European Journal of Pediatrics, 181, 2549-2561. https://doi.org/10.1007/s00431-022-04455-2
[27]
Wood, C.L. and Straub, V. (2018) Bones and Muscular Dystrophies: What Do We Know? Current Opinion in Neurology, 31, 583-591. https://doi.org/10.1097/wco.0000000000000603
[28]
Rahmati, M., Haffner, M., Lee, M.A., Leach, J.K. and Saiz, A.M. (2023) The Critical Impact of Traumatic Muscle Loss on Fracture Healing: Basic Science and Clinical Aspects. Journal of Orthopaedic Research, 42, 249-258. https://doi.org/10.1002/jor.25746
[29]
Wang, B., Liu, Q., Liu, Y. and Jiang, R. (2019) Comparison of Proximal Femoral Nail Antirotation and Dynamic Hip Screw Internal Fixation on Serum Markers in Elderly Patients with Intertrochanteric Fractures. Journal of the College of Physicians and Surgeons Pakistan, 29, 644-648. https://doi.org/10.29271/jcpsp.2019.07.644
[30]
Delsmann, M.M., Stürznickel, J., Amling, M., Ueblacker, P. and Rolvien, T. (2021) Muskuloskelettale Labordiagnostik im Leistungssport. Der Orthopäde, 50, 700-712. https://doi.org/10.1007/s00132-021-04072-1
[31]
Ji, S., Jiang, X., Han, H., Wang, C., Wang, C. and Yang, D. (2022) Prediabetes and Osteoporotic Fracture Risk: A Meta-Analysis of Prospective Cohort Studies. Diabetes/Metabolism Research and Reviews, 38, e3568. https://doi.org/10.1002/dmrr.3568
[32]
Zhang, Y., Zheng, P., Shi, J., Ma, Y., Chen, Z., Wang, T., et al. (2023) Associations of Ambient Temperature with Creatine Kinase MB and Creatine Kinase: A Large Sample Time Series Study of the Chinese Male Population. Science of the Total Environment, 880, Article ID: 163250. https://doi.org/10.1016/j.scitotenv.2023.163250
[33]
Li, X., Pan, X., Li, Y., An, N., Xing, Y., Yang, F., et al. (2020) Cardiac Injury Associated with Severe Disease or ICU Admission and Death in Hospitalized Patients with COVID-19: A Meta-Analysis and Systematic Review. Critical Care, 24, Article No. 468. https://doi.org/10.1186/s13054-020-03183-z
[34]
Tanaka, M., Mori, H., Kayasuga, R. and Kawabata, K. (2015) Induction of Creatine Kinase Release from Cultured Osteoclasts via the Pharmacological Action of Aminobisphosphonates. SpringerPlus, 4, Article No. 59. https://doi.org/10.1186/s40064-015-0848-3
