Stroke is currently one of the main causes of death and disability worldwide, with numerous reports indicating that it can lead to various functional impairments such as motor, sensory, swallowing, cognitive, emotional, and speech disorders following its occurrence. Among these, swallowing disorder is a relatively severe complication, which can easily lead to malnutrition, reduced quality of life, and aspiration pneumonia in patients, severely affecting their daily life and the outcome of the disease. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique, and many studies have shown that it can significantly improve swallowing disorders after stroke. This article summarizes the possible pathogenesis of swallowing disorders after stroke and the mechanism of action of rTMS on the therapeutic effects for patients.
References
[1]
Li, J.Y., Liu, Z.J., Qi, H.J., et al. (2024) Research Progress of Transcranial Magnetic Stimulation in Post-Stroke Dysphagia Rehabilitation. China Geriatric Healthcare Medicine, 22, 7-11.
[2]
Beharry, A., Michel, P., Faouzi, M., Kuntzer, T., Schweizer, V. and Diserens, K. (2019) Predictive Factors of Swallowing Disorders and Bronchopneumonia in Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases, 28, 2148-2154. https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.04.025
[3]
Ye, G. (2003) Clinical Rehabilitation. Hualiang Publishing House, 57.
[4]
Meng, N., Wang, T. and Lien, I. (2000) Dysphagia in Patients with Brainstem Stroke: Incidence and Outcome. American Journal of Physical Medicine & Rehabilitation, 79, 170-175. https://doi.org/10.1097/00002060-200003000-00010
[5]
Galovic, M., Stauber, A.J., Leisi, N., Krammer, W., Brugger, F., Vehoff, J., et al. (2019) Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding after Ischemic Stroke. JAMA Neurology, 76, 561-570. https://doi.org/10.1001/jamaneurol.2018.4858
[6]
Liu, S.D., Chen, Q.B., Li, R.Z., et al. (2012) Progress of Swallowing Disorders in Cerebrovascular Diseases. China Clinical New Medicine, 5, 367-371.
[7]
Steuer, I. and Guertin, P.A. (2018) Central Pattern Generators in the Brainstem and Spinal Cord: An Overview of Basic Principles, Similarities and Differences. Reviews in the Neurosciences, 30, 107-164. https://doi.org/10.1515/revneuro-2017-0102
[8]
Zhang, L., Tang, X., Wang, C., Ding, D., Zhu, J., Zhou, Y., et al. (2021) Predictive Model of Dysphagia and Brain Lesion-Symptom Mapping in Acute Ischemic Stroke. Frontiers in Aging Neuroscience, 13, Article 753364. https://doi.org/10.3389/fnagi.2021.753364
[9]
Lapa, S., Foerch, C., Singer, O.C., Hattingen, E. and Luger, S. (2020) Ischemic Lesion Location Based on the ASPECT Score for Risk Assessment of Neurogenic Dysphagia. Dysphagia, 36, 882-890. https://doi.org/10.1007/s00455-020-10204-0
[10]
Nakamori, M., Hosomi, N., Imamura, E., Matsushima, H., Maetani, Y., Yoshida, M., et al. (2020) Association between Stroke Lesions and Videofluoroscopic Findings in Acute Stroke Patients. Journal of Neurology, 268, 1025-1035. https://doi.org/10.1007/s00415-020-10244-4
[11]
Hess, F., Foerch, C., Keil, F., Seiler, A. and Lapa, S. (2021) Association of Lesion Pattern and Dysphagia in Acute Intracerebral Hemorrhage. Stroke, 52, 2921-2929. https://doi.org/10.1161/strokeaha.120.032615
[12]
Moon, H.I., Jeong, Y.J. and Suh, J.H. (2021) Voxel-Based Lesion Symptom Mapping Analysis for Dysphagia in Stroke Patients with Isolated Cerebellar Lesions. Journal of Neural Transmission, 129, 65-74. https://doi.org/10.1007/s00702-021-02438-5
[13]
Labeit, B., Jung, A., Ahring, S., Oelenberg, S., Muhle, P., Roderigo, M., et al. (2023) Relationship between Post-Stroke Dysphagia and Pharyngeal Sensory Impairment. Neurological Research and Practice, 5, Article No. 7. https://doi.org/10.1186/s42466-023-00233-z
[14]
Cabib, C., Nascimento, W., Rofes, L., Arreola, V., Tomsen, N., Mundet, L., et al. (2020) Short-Term Neurophysiological Effects of Sensory Pathway Neurorehabilitation Strategies on Chronic Poststroke Oropharyngeal Dysphagia. Neurogastroenterology & Motility, 32, e13887. https://doi.org/10.1111/nmo.13887
[15]
Kobayashi, M. and Pascual-Leone, A. (2003) Transcranial Magnetic Stimulation in Neurology. The Lancet Neurology, 2, 145-156. https://doi.org/10.1016/s1474-4422(03)00321-1
[16]
Yamashita, A., Murakami, T., Hattori, N., Miyai, I. and Ugawa, Y. (2021) Intensity Dependency of Peripheral Nerve Stimulation in Spinal LTP Induced by Paired Associative Corticospinal-Motoneuronal Stimulation (PCMs). PLOS ONE, 16, e0259931. https://doi.org/10.1371/journal.pone.0259931
[17]
Boddington, L.J. and Reynolds, J.N.J. (2017) Targeting Interhemispheric Inhibition with Neuromodulation to Enhance Stroke Rehabilitation. Brain Stimulation, 10, 214-222. https://doi.org/10.1016/j.brs.2017.01.006
[18]
Di Pino, G., Pellegrino, G., Assenza, G., Capone, F., Ferreri, F., Formica, D., et al. (2014) Modulation of Brain Plasticity in Stroke: A Novel Model for Neurorehabilitation. Nature Reviews Neurology, 10, 597-608. https://doi.org/10.1038/nrneurol.2014.162
[19]
Barritt, A.W. and Smithard, D.G. (2008) Role of Cerebral Cortex Plasticity in the Recovery of Swallowing Function Following Dysphagic Stroke. Dysphagia, 24, 83-90. https://doi.org/10.1007/s00455-008-9162-3
[20]
Rogalewski, A. and Schäbitz, W. (2022) Stroke Recovery Enhancing Therapies: Lessons from Recent Clinical Trials. Neural Regeneration Research, 17, 717-720. https://doi.org/10.4103/1673-5374.314287
[21]
Aswendt, M. and Wieters, F. (2021) Structural Integrity and Remodeling Underlying Functional Recovery after Stroke. Neural Regeneration Research, 16, 1423-1424. https://doi.org/10.4103/1673-5374.301004
[22]
Eysel, U.T. and Jancke, D. (2023) Induction of Excitatory Brain State Governs Plastic Functional Changes in Visual Cortical Topology. Brain Structure and Function, 229, 531-547. https://doi.org/10.1007/s00429-023-02730-y
[23]
Starosta, M., Cichoń, N., Saluk-Bijak, J. and Miller, E. (2022) Benefits from Repetitive Transcranial Magnetic Stimulation in Post-Stroke Rehabilitation. Journal of Clinical Medicine, 11, Article 2149. https://doi.org/10.3390/jcm11082149
[24]
Villa, R.F., Ferrari, F. and Moretti, A. (2018) Post-Stroke Depression: Mechanisms and Pharmacological Treatment. Pharmacology & Therapeutics, 184, 131-144. https://doi.org/10.1016/j.pharmthera.2017.11.005
[25]
Ikeda, T., Kobayashi, S. and Morimoto, C. (2018) Gene Expression Microarray Data from Mouse CBS Treated with RTMs for 30 Days, Mouse Cerebrum and CBS Treated with RTMs for 40 Days. Data in Brief, 17, 1078-1081. https://doi.org/10.1016/j.dib.2018.01.079
[26]
Zhang, X., Li, L., Huo, J., Cheng, M. and Li, L. (2018) Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Function and Cholinergic Activity in the Rat Hippocampus after Vascular Dementia. Neural Regeneration Research, 13, 1384-1389. https://doi.org/10.4103/1673-5374.235251
[27]
Luo, J., Zheng, H., Zhang, L., Zhang, Q., Li, L., Pei, Z., et al. (2017) High-Frequency Repetitive Transcranial Magnetic Stimulation (RTMs) Improves Functional Recovery by Enhancing Neurogenesis and Activating BDNF/TRKB Signaling in Ischemic Rats. International Journal of Molecular Sciences, 18, Article 455. https://doi.org/10.3390/ijms18020455
[28]
Medina-Fernández, F.J., Luque, E., Aguilar-Luque, M., Agüera, E., Feijóo, M., García-Maceira, F.I., et al. (2017) Transcranial Magnetic Stimulation Modifies Astrocytosis, Cell Density and Lipopolysaccharide Levels in Experimental Autoimmune Encephalomyelitis. Life Sciences, 169, 20-26. https://doi.org/10.1016/j.lfs.2016.11.011
[29]
Zong, X., Li, Y., Liu, C., Qi, W., Han, D., Tucker, L., et al. (2020) Theta-Burst Transcranial Magnetic Stimulation Promotes Stroke Recovery by Vascular Protection and Neovascularization. Theranostics, 10, 12090-12110. https://doi.org/10.7150/thno.51573
[30]
Alsbrook, D.L., Di Napoli, M., Bhatia, K., Biller, J., Andalib, S., Hinduja, A., et al. (2023) Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke. Current Neurology and Neuroscience Reports, 23, 407-431. https://doi.org/10.1007/s11910-023-01282-2
[31]
Zhu, H., Wang, Z., Yu, J., Yang, X., He, F., Liu, Z., et al. (2019) Role and Mechanisms of Cytokines in the Secondary Brain Injury after Intracerebral Hemorrhage. Progress in Neurobiology, 178, Article ID: 101610. https://doi.org/10.1016/j.pneurobio.2019.03.003
[32]
Palomo, J., Dietrich, D., Martin, P., Palmer, G. and Gabay, C. (2015) The Interleukin (IL)-1 Cytokine Family—Balance between Agonists and Antagonists in Inflammatory Diseases. Cytokine, 76, 25-37. https://doi.org/10.1016/j.cyto.2015.06.017
[33]
Zhu, H., Hu, S., Li, Y., Sun, Y., Xiong, X., Hu, X., et al. (2022) Interleukins and Ischemic Stroke. Frontiers in Immunology, 13, Article 828447. https://doi.org/10.3389/fimmu.2022.828447
[34]
Abd-El-Basset, E.M., Rao, M.S., Alshawaf, S.M., Ashkanani, H.K. and Kabli, A.H. (2021) Tumor Necrosis Factor (TNF) Induces Astrogliosis, Microgliosis and Promotes Survival of Cortical Neurons. AIMS Neuroscience, 8, 558-584. https://doi.org/10.3934/neuroscience.2021031
[35]
Garcia, J.M., Stillings, S.A., Leclerc, J.L., Phillips, H., Edwards, N.J., Robicsek, S.A., et al. (2017) Role of Interleukin-10 in Acute Brain Injuries. Frontiers in Neurology, 8, Article 244. https://doi.org/10.3389/fneur.2017.00244
[36]
Salter, M.W. and Stevens, B. (2017) Microglia Emerge as Central Players in Brain Disease. Nature Medicine, 23, 1018-1027. https://doi.org/10.1038/nm.4397
[37]
Nair, K.P.S. and Taly, A.B. (2002) Stroke Rehabilitation: Traditional and Modern Approaches. Neurology India, 50, S85-S93.
[38]
Cheng, I. and Hamdy, S. (2021) Current Perspectives on the Benefits, Risks, and Limitations of Noninvasive Brain Stimulation (NIBS) for Post-Stroke Dysphagia. Expert Review of Neurotherapeutics, 21, 1135-1146. https://doi.org/10.1080/14737175.2021.1974841
[39]
Cabib, C., Ortega, O., Kumru, H., Palomeras, E., Vilardell, N., Alvarez‐Berdugo, D., et al. (2016) Neurorehabilitation Strategies for Poststroke Oropharyngeal Dysphagia: From Compensation to the Recovery of Swallowing Function. Annals of the New York Academy of Sciences, 1380, 121-138. https://doi.org/10.1111/nyas.13135
[40]
Urushidani, N., Kinoshita, S., Okamoto, T., Tamashiro, H. and Abo, M. (2018) Low-frequency RTMs and Intensive Occupational Therapy Improve Upper Limb Motor Function and Cortical Reorganization Assessed by Functional Near-Infrared Spectroscopy in a Subacute Stroke Patient. Case Reports in Neurology, 10, 223-231. https://doi.org/10.1159/000492381
[41]
Frey, J., Najib, U., Petrone, A., Tirumalai, P., Sherman, J., Moore, L., et al. (2020) Abstract WP195: Accelerated Repetitive Transcranial Magnetic Stimulation (RTMs) as a Treatment for Subacute Post-Stroke Depression (PSD). Stroke, 51. https://doi.org/10.1161/str.51.suppl_1.wp195
[42]
Zhang, Y., Ma, M., Cai, Q., et al. (2018) The Curative Effects of Magnetic versus Electrical Stimulation in Treating Pharyngeal Dysphagia. Chinese Journal of Physical Medicine and Rehabilitation, 424-427.
[43]
Wassermann, E.M. (1998) Risk and Safety of Repetitive Transcranial Magnetic Stimulation: Report and Suggested Guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 108, 1-16. https://doi.org/10.1016/s0168-5597(97)00096-8
[44]
Thiel, A., Hartmann, A., Rubi-Fessen, I., Anglade, C., Kracht, L., Weiduschat, N., et al. (2013) Effects of Noninvasive Brain Stimulation on Language Networks and Recovery in Early Poststroke Aphasia. Stroke, 44, 2240-2246. https://doi.org/10.1161/strokeaha.111.000574
[45]
Duan, X., Yao, G., Liu, Z., Cui, R. and Yang, W. (2018) Mechanisms of Transcranial Magnetic Stimulation Treating on Post-Stroke Depression. Frontiers in Human Neuroscience, 12, Article 215. https://doi.org/10.3389/fnhum.2018.00215
[46]
Yang, Q., Chen, S., Deng, P. and Jia, J. (2018) Peripheral Plus Central Repetitive Transcranial Magnetic Stimulation (RTMs) for Upper Limb Motor Rehabilitation in Chronic Stroke—A Case Report. Annals of Physical and Rehabilitation Medicine, 61, e215-e216. https://doi.org/10.1016/j.rehab.2018.05.499