AI-driven drug repurposing is shaking things up in the world of oncology. It uses artificial intelligence (AI) to find new cancer treatments from drugs that are already approved by the FDA. This innovative approach taps into machine learning algorithms, extensive biological datasets, and sophisticated computational models to uncover potential new uses for medications that were initially created for different health issues. In oncology, where options can be limited due to challenges like drug resistance and the diversity of tumors, AI has the power to reveal fresh, effective treatment possibilities by sifting through complex molecular, genomic, and clinical data. This speedy identification of promising drug candidates can greatly cut down on the time, costs, and risks typically associated with traditional drug development. This paper dives into how AI is being applied in drug repurposing for cancer treatment, showcasing recent achievements, the merging of AI with clinical data, and the potential for tailored treatment strategies. It also looks at the hurdles in data integration, model validation, and getting regulatory approval, while pointing out future paths for the field.
References
[1]
Tanoli, Z., Vähä-Koskela, M. and Aittokallio, T. (2021) Artificial Intelligence, Machine Learning, and Drug Repurposing in Cancer. Expert Opinion on Drug Discovery, 16, 977-989. https://doi.org/10.1080/17460441.2021.1883585
[2]
Garg, P., Singhal, G., Kulkarni, P., Horne, D., Salgia, R. and Singhal, S.S. (2024) Artificial Intelligence-Driven Computational Approaches in the Development of Anticancer Drugs. Cancers, 16, Article 3884. https://doi.org/10.3390/cancers16223884
[3]
Wang, J., Kong, S., Bo, X., Wang, Y., He, S. and Bai, H. (2024) Drug Repositioning in the AI-Driven Era: Data, Approaches, and Challenges.
Gangwal, A. and Lavecchia, A. (2024) AI-Driven Drug Discovery for Rare Diseases. Journal of Chemical Information and Modeling, 65, 2214-2231. https://doi.org/10.1021/acs.jcim.4c01966
[6]
Adamopoulos, C., Papavassiliou, K.A. and Papavassiliou, A.G. (2024) Fusing Artificial Intelligence and Machine Learning for Anti-Cancer Drug Discovery. Cancers, 16, Article 3522. https://doi.org/10.3390/cancers16203522
[7]
Ozaybi, M.Q.B., Madkhali, A.N.M., Alhazmi, M.A.M., et al. (2024) The Role of Artificial Intelligence in Drug Discovery and Development. Egyptian Journal of Chemistry, 67, 1541-1547. https://doi.org/10.21608/ejchem.2024.337877.10835
[8]
Loewe, R.P., Nogales, C., Olexiouk, V., Schmidt, R. and Krahn, T. (2024) Diagnostics for Repurposed Drugs. DrugRxiv.
[9]
Ng, C.K., Long, J., Tang, M., Li, J. and Quan, M. (2024) Exploring AI-Driven Drug Repurposing Strategies Targeting ErbB Signalling Pathway for Brain Cancer Therapy. 2024 IEEE International Conference on Cybernetics and Intelligent Systems (CIS) and IEEE International Conference on Robotics, Automation and Mechatronics (RAM), Hangzhou, 8-11 August 2024, 555-560. https://doi.org/10.1109/cis-ram61939.2024.10673264
[10]
Tran, N.L., Kim, H., Shin, C., Ko, E. and Oh, S.J. (2023) Artificial Intelligence-Driven New Drug Discovery Targeting Serine/Threonine Kinase 33 for Cancer Treatment. Cancer Cell International, 23, Article No. 321. https://doi.org/10.1186/s12935-023-03176-2
[11]
Pun, F.W., Ozerov, I.V. and Zhavoronkov, A. (2023) AI-Powered Therapeutic Target Discovery. Trends in Pharmacological Sciences, 44, 561-572. https://doi.org/10.1016/j.tips.2023.06.010
[12]
Bajpai, S., Shreyash, N., Sonker, M., Gupta, V., Tiwary, S.K. and Biswas, S. (2021) Concept of Artificial Intelligence in Discovering and Re-Purposing of Drugs. MedPharm.
[13]
Rasool, S., Ali, M., Shahroz, H.M., Hussain, H.K. and Gill, A.Y. (2024) Innovations in AI-Powered Healthcare: Transforming Cancer Treatment with Innovative Methods. BULLET: JurnalMultidisiplinIlmu, 3, 118-128.
[14]
Alsharif, F. (2024) Artificial Intelligence in Oncology: Applications, Challenges and Future Frontiers. International Journal of Pharmaceutical Investigation, 14, 647-656. https://doi.org/10.5530/ijpi.14.3.76
[15]
Shahzad, K., Zanona, M.A., Elzaghmouri, B.M., AbdelRahman, S.M., Osman, A.A.F. and Khateeb, A. (2024) Using Artificial Intelligence and Machine Learning Approaches to Enhance Cancer Therapy and Drug Discovery. Journal of Ayub Medical College Abbottabad, 36, 183-189. https://doi.org/10.55519/jamc-01-12921
[16]
Duo, L., Liu, Y., Ren, J., Tang, B. and Hirst, J.D. (2024) Artificial Intelligence for Small Molecule Anticancer Drug Discovery. Expert Opinion on Drug Discovery, 19, 933-948. https://doi.org/10.1080/17460441.2024.2367014
[17]
Workman, P., Antolin, A.A. and Al-Lazikani, B. (2019) Transforming Cancer Drug Discovery with Big Data and AI. Expert Opinion on Drug Discovery, 14, 1089-1095. https://doi.org/10.1080/17460441.2019.1637414
[18]
Visan, A.I. and Negut, I. (2024) Integrating Artificial Intelligence for Drug Discovery in the Context of Revolutionizing Drug Delivery. Life, 14, Article 233. https://doi.org/10.3390/life14020233
[19]
Rehan, H. (2024) Advancing Cancer Treatment with AI-Driven Personalized Medicine and Cloud-Based Data Integration. Journal of Machine Learning in Pharmaceutical Research, 4, 1-40.
[20]
Oloruntoba, O. (2024) Generative AI for Creative Data Management: Optimizing Database Systems in the Creative Industry. Iconic Research And Engineering Journals, 8, 588-597.
[21]
Abbas, M.K.G., Rassam, A., Karamshahi, F., Abunora, R. and Abouseada, M. (2024) The Role of AI in Drug Discovery. ChemBioChem, 25, e202300816. https://doi.org/10.1002/cbic.202300816
[22]
Debnath, R., Ikbal, A.M.A., Choudhury, A., Mandal, S.C. and Palit, P. (2024) Artificial Intelligence: A Major Landmark in the Novel Drug Discovery Pathway for the Remarkable Advancement in the Healthcare System. In: Interdisciplinary Biotechnological Advances, Springer, 413-436. https://doi.org/10.1007/978-981-97-1148-2_19
[23]
Shanmuga Sundari, M., Penthala, H.R., Mogullapalli, A. and Ammangatambu, M.M. (2024) AI‐Based Personalized Drug Treatment. In: Artificial Intelligence and Machine Learning in Drug Design and Development, Wiley, 369-406.
[24]
Khan, I.R., Grover, V., Fatima, I., Alam, M. and Ahmad, N. (2024) The Application of AI in Drug Discovery. In: AdvancesinHealthcareInformationSystemsandAdministration, IGI Global, 181-198. https://doi.org/10.4018/979-8-3693-5468-1.ch010