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经皮穴位电刺激镇静作用的认知机制：来自ERP的证据
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Abstract:
经皮穴位电刺激(TEAS)是一种融合了传统中医经络理论和神经电生理技术的治疗方法，具有镇静作用。为考查TEAS镇静作用的认知机制，本研究以28名健康大学生为被试，采用负性情绪图片诱发负性情绪，在神门穴施予TEAS (刺激频率2/100 Hz，疏密波，电流强度为10 mA)，在TEAS干预前后采用视觉oddball范式诱发脑电特征成分P300。结果显示：经TEAS干预后，大脑皮层中线区域P300波幅显著降低，并且在100 ms至400 ms时间窗内大脑皮层中央脑区、额叶区和枕叶区的激活面积减少，激活强度降低。结果提示，TEAS的镇静作用与认知资源投入减少，记忆和注意功能降低有关。
Transcutaneous electrical acupoint stimulation (TEAS) is a therapeutic intervention that integrates principles from traditional Chinese meridian theory with neuroelectrophysiological techniques, demonstrating notable sedative effects. To investigate the cognitive mechanisms underlying these sedative effects, this study recruited 28 healthy participants. Negative emotional states were induced using emotionally aversive images, and TEAS was applied to the Shenmen (HT7) acupoint (stimulation parameters: 2/100 Hz dense-disperse waves, 10 mA current intensity). Event-related potentials (ERPs) were recorded before and after TEAS intervention using a visual oddball paradigm to elicit the P300 component. The results revealed a significant reduction in P300 amplitude over the midline cortical regions following TEAS intervention. Furthermore, within the 100~400 ms time window, decreased activation areas and diminished activation intensity were observed in the central, frontal, and occipital cortical regions. These findings suggest that the sedative effects of TEAS are associated with reduced allocation of cognitive resources, accompanied by attenuated memory and attentional functioning.
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