In the rat, perinatal undernutrition associated with deficiencies in the mother-litter interactions, interferes with cortical subcortical networks underlying swimming and kyphotic responses of lactating dams. For swimming experiment, food restriction was achieved by separating pups from the mother (12 h daily) in an incubator from ages P4 - 13. Moreover, for kyphotic response, food intake was reduced from gestational day 6 (G6) with 50% (9.5 g) of the normal diet (Purina chow), from G13 to G19 with 70% (13.3 g), and with 100% (19 g) of the same diet until parturition. After birth, prenatally underfed pups were rotated between litter of two lactating dams, one with ligated nipples, for 12 h daily between ages of P2 - 25. We evaluated swimming maturation and the kyphotic posture of dams by exposing pups, correlated with their tentative cervical and lumbosacral spinal cord descending integrative mechanisms. Current findings suggest that the pattern of the spinal cord substrates in both behavioral responses affected by early undernutrition, changed according to the future complexity of the functional and incoming environmental sensory information.
References
[1]
Teicher, M.H. and Blass, E.M. (1977) First Suckling Response of the Newborn Albino Rat: The Roles of Olfaction and Amniotic Fluid. Science, 198, 635-636. https://doi.org/10.1126/science.918660
[2]
Brouettelahlou, I., Godinot, F. and Vernetmaury, E. (1999) The Mother Rat’s Vomeronasal Organ Is Involved in Detection of Dodecyl Propionate, the Pup’s Preputial Gland Pheromone. Physiology&Behavior, 66, 427-436. https://doi.org/10.1016/s0031-9384(98)00334-5
[3]
Febo, M., Stolberg, T.L., Numan, M., Bridges, R.S., Kulkarni, P. and Ferris, C.F. (2008) Nursing Stimulation Is More than Tactile Sensation: It Is a Multisensory Experience. HormonesandBehavior, 54, 330-339. https://doi.org/10.1016/j.yhbeh.2008.02.024
[4]
Salcedo, C., Torrero, C., Regalado, M., Rubio, L. and Salas, M. (2018) Effects of Pre-and Neonatal Undernutrition on the Kyphotic Response and C-Fos Activity in the Caudal Periaqueductal Gray of Primiparous Lactating Wistar Rats. Physiology&Behavior, 185, 87-94. https://doi.org/10.1016/j.physbeh.2017.12.020
[5]
Groenewegen, H.J. and Uylings, H.B.M. (2000) The Prefrontal Cortex and the Integration of Sensory, Limbic and Autonomic Information. ProgressinBrainResearch, 126, 3-28. https://doi.org/10.1016/s0079-6123(00)26003-2
[6]
Numan, M. (2006) Motivational Systems and the Neural Circuitry of Maternal Behavior in the Rat. DevelopmentalPsychobiology, 49, 12-21. https://doi.org/10.1002/dev.20198
[7]
Ahmed, A.O. and Buckley, P.F. (2013) The Archaeology of Mind: The Neuroevolutionary Origins of Human Emotions, by Jaak Panksepp and Lucy Biven. JournalofNervous&MentalDisease, 201, 719-720. https://doi.org/10.1097/nmd.0b013e31829c50e6
[8]
Panksepp J, and Biven L. (2012) The Archeology of Mind Neuroevolutionary: Origins of Human Emotions. WW. Norton & Company.
[9]
Salas, M., Torrero, C. and Regalado, M. (2024) Maternal Behavioral Disorders Associated with Neuronal Changes in the Lateral Habenula of Pre and Neonatally Underfed Rats. eNeurobiología, 15, 1-13. https://doi.org/10.25009/eb.v15i37.2630
[10]
Smart, J.L. (1976) Maternal Behaviour of Undernourished Mother Rats Towards Well Fed and Underfed Young. Physiology&Behavior, 16, 147-149. https://doi.org/10.1016/0031-9384(76)90298-5
[11]
Yamamuro, Y. and Sensui, N. (2000) Maternal Behavior and Emotional Status of Mother Rats at Different Stages of Lactation. NihonChikusanGakkaiho, 71, 208-213. https://doi.org/10.2508/chikusan.71.208
[12]
Torrero, C., Regalado, M., Rubio, L. and Salas, M. (2014) Effects of Neonatal Undernutrition on Development of the Dorsolateral Prefrontal Cortex Pyramidal Cells in the Rat. JournalofBehavioralandBrainScience, 4, 49-57. https://doi.org/10.4236/jbbs.2014.41007
[13]
Salas, M., Torrero, C., Regalado, M. and Rubio, L. (2015) Effects of Perinatal Undernutrition on the Basilar Dendritic Arbor of the Anterior Cingulate Pyramidal Neurons in Lactating Dams. ActaNeurobiologiaeExperimentalis, 75, 372-380. https://doi.org/10.55782/ane-2015-2042
[14]
Ortiz-Valladares, M., Torrero, C., Regalado, M. and Salas, M. (2018) Late-Emerging Effects of Perinatal Undernutrition in Neuronal Limbic Structures Underlying the Maternal Response in the Rat. BrainResearch, 1700, 31-40. https://doi.org/10.1016/j.brainres.2018.06.033
[15]
Vinay, L., Brocard, F., Pflieger, J., Simeoni-Alias, J. and Clarac, F. (2000) Perinatal Development of Lumbar Motoneurons and Their Inputs in the Rat. BrainResearchBulletin, 53, 635-647. https://doi.org/10.1016/s0361-9230(00)00397-x
[16]
Dow, R.S. and Moruzzi, G. (1958) The Physiology and Pathology of the Cerebellum. University of Minneapolis Press.
[17]
Wilson, V.J. and Yoshida, M. (1969) Bilateral Connections between Labyrinths and Neck Motoneurons. BrainResearch, 13, 603-607. https://doi.org/10.1016/0006-8993(69)90271-6
[18]
Takahashi, S., Tanaka, H. and Oki, J. (1999) Development of Spinal Motoneurons in Rats after a Neonatal Hypoxic Insult. PediatricNeurology, 21, 715-720. https://doi.org/10.1016/s0887-8994(99)00080-6
[19]
Salas, M. (1972) Effects of Early Malnutrition on the Development of Swimming Ability in the Rat. Physiology&Behavior, 8, 119-122. https://doi.org/10.1016/0031-9384(72)90137-0
[20]
Schapiro, S., Salas, M. and Vukovich, K. (1970) Hormonal Effects on Ontogeny of Swimming Ability in the Rat: Assessment of Central Nervous System Development. Science, 168, 147-151. https://doi.org/10.1126/science.168.3927.147
[21]
Gernandt, B.E. and Gilman, S. (1959) Descending Vestibular Activity and Its Modulation by Proprioceptive, Cerebellar, and Reticular Influences. ExperimentalNeurology, 1, 274-304. https://doi.org/10.1016/0014-4886(59)90005-6
[22]
Salas, M. and Cintra, L. (1973) Nutritional Influences Upon Somatosensory Evoked Responses during Development in the Rat. Physiology&Behavior, 10, 1019-1022. https://doi.org/10.1016/0031-9384(73)90182-0
[23]
Salas, M., Di’az, S. and Nieto, A. (1974) Effects of Neonatal Food Deprivation on Cortical Spines and Dendritic Development of the Rat. BrainResearch, 73, 139-144. https://doi.org/10.1016/0006-8993(74)91012-9
[24]
McConnell, P. and Berry, M. (1978) The Effect of Refeeding after Neonatal Starvation on Purkinje Cell Dendritic Growth in the Rat. JournalofComparativeNeurology, 178, 759-772. https://doi.org/10.1002/cne.901780410
[25]
Joosten, E.A.J., Gribnau, A.A.M. and Dederen, P.J.W.C. (1987) An Anterograde Tracer Study of the Developing Corticospinal Tract in the Rat: Three Components. DevelopmentalBrainResearch, 36, 121-130. https://doi.org/10.1016/0165-3806(87)90070-8
[26]
Purves, D., Augustine, G.J., Fitzpatrick, D., Hall, W.C., Lamantia, A.S. and White, L.E. (2016) Neurociencia. Fifth Edition, Panamericana.
[27]
Grota, L.J. and Ader, R. (1969) Continuous Recording of Maternal Behaviour in Rattus Norvegicus. AnimalBehaviour, 17, 722-729. https://doi.org/10.1016/s0003-3472(69)80019-9
[28]
Lonstein, J.S. and Stern, J.M. (1997) Somatosensory Contributions to C-Fosactivation within the Caudal Periaqueductal Gray of Lactating Rats: Effects of Perioral, Rooting, and Suckling Stimuli from Pups. HormonesandBehavior, 32, 155-166. https://doi.org/10.1006/hbeh.1997.1416
[29]
Morgan, H.D., Fleming, A.S. and Stern, J.M. (1992) Somatosensory Control of the Onset and Retention of Maternal Responsiveness in Primiparous Sprague-Dawley Rats. Physiology&Behavior, 51, 549-555. https://doi.org/10.1016/0031-9384(92)90178-5
[30]
Salas, M., Torrero, C. and Pulido, S. (1984) Long-Term Alterations in the Maternal Behavior of Neonatally Undernourished Rats. Physiology&Behavior, 33, 273-278. https://doi.org/10.1016/0031-9384(84)90111-2
[31]
Salas, M., Regalado, M. and Torrero, C. (2001) Recovery of Long-Term Maternal Behavioral Deficiencies of Neonatally Underfed Rats by Early Sensory Stimulation: Effects of Successive Parturitions. NutritionalNeuroscience, 4, 311-322. https://doi.org/10.1080/1028415x.2001.11747371
[32]
Lonstein, J.S., Simmons, D.A., Swann, J.M. and Stern, J.M. (1997) Forebrain Expression of C-Fos Due to Active Maternal Behaviour in Lactating Rats. Neuroscience, 82, 267-281. https://doi.org/10.1016/s0306-4522(97)00283-2
[33]
Lloyd, D.P.C. (1946) Facilitation and Inhibition of Spinal Motoneurons. JournalofNeurophysiology, 9, 421-438. https://doi.org/10.1152/jn.1946.9.6.421
[34]
Guzmán-Flores, C., Pacheco, P., Salas, M. and Alcaraz, M. (1964) Some Data for a Neuro-Physiological Model of Learning. In Feedback Systems Controlling Nervous Activity, Sociedad Mexicana de Ciencias Fisiológicas, 117-126.
[35]
Ayala-Moreno, R., Racotta, R., Anguiano, B., Aceves, C. and Quevedo, L. (2013) Perinatal Undernutrition Programmes Thyroid Function in the Adult Rat Offspring. BritishJournalofNutrition, 110, 2207-2215. https://doi.org/10.1017/s0007114513001736
Sarabdjitsingh, R.A., Loi, M., Joëls, M., Dijkhuizen, R.M. and van der Toorn, A. (2017) Early Life Stress-Induced Alterations in Rat Brain Structures Measured with High Resolution MRI. PLOSONE, 12, e0185061. https://doi.org/10.1371/journal.pone.0185061
