基于数据挖掘研究风邪致龋型龋病的用药规律
Based on Data Mining Studying the Medication Patterns of Dental Caries Caused by Wind Pathogen

目的：分析中医古籍中“风邪致龋”型龋病的用药规律方法：检索《中华医典》数据库中龋病的条文，提取并规范化处理，对纳入处方中的中药及其性味归经进行频数分析、聚类分析、关联规则分析。结果：共纳入119首外治方剂，涉及123味中药，药物总使用频次582，药性以温性最多，其次为热性、寒性；药味以辛味为主，其次为苦味、甘味；归经以脾经为主，其次为胃经、肾经。使用频数 ≥ 11的药物共16味，以解表药、温里药、攻毒杀虫止痒药为主。关联规则分析共得到13组核心配伍，药对组合以细辛–白芷–花椒、细辛–荆芥–花椒最常见；高频药物聚类分析得到3类核心药物组合。结论：古代中医治疗“风邪致龋”型龋病，以祛风为主，兼杀虫、除湿、清热、活血。
Objective: To analyze the medication rules for “wind-induced caries” type caries in ancient Chinese medical literature. Methods: The relevant articles on caries in the “Chinese Medical Canon” database were retrieved, extracted and normalized. Frequency analysis, cluster analysis and association rule analysis were conducted on the included prescriptions and their properties and meridians. Results: A total of 119 external treatment prescriptions were included, involving 123 Chinese medicines, with a total usage frequency of 582. The most common property was warm, followed by hot and cold; the most common taste was pungent, followed by bitter and sweet; the most common meridian was the spleen meridian, followed by the stomach meridian and the kidney meridian. There were 16 drugs with a usage frequency of ≥ 11, mainly including surface-releasing drugs, warming interior drugs, and insecticidal, detoxifying and pruritus-relieving drugs. Association rule analysis yielded 13 core combinations, with the most common drug pairs being Xixin-Baizhi-HuaJiao and Xixin-Jingjie-HuaJiao. High-frequency drug cluster analysis resulted in 3 core drug combinations. Conclusion: Ancient Chinese medicine treated “wind-induced caries” type caries mainly by dispelling wind, and also by killing parasites, removing dampness, clearing heat and promoting blood circulation.