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葡萄糖胺和鱼油与尿石症风险的关系：一项大型前瞻性队列研究
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Abstract:
目的：探讨葡萄糖胺和鱼油与尿石症风险的关系，旨在为预防尿石症提供饮食指导。方法：通过英国生物银行从英国各地招募了约50万名年龄在40~69岁之间的参与者，通过下载国外公开数据库数据用于本研究。结果：葡萄糖胺使用者的尿石症风险显著降低(HR = 0.77, 95% CI: 0.72~0.83, P < 0.0001)。鱼油使用者在年龄调整和多变量调整模型中均表现出显著的尿石症风险降低(HR = 0.90, 95% CI: 0.84~0.95, P = 0.0006)。联合使用鱼油和葡萄糖胺的参与者表现出最强的保护效应。与非使用者相比，联合使用者的尿石症风险显著降低(HR = 0.83, 95% CI: 0.75~0.90, P < 0.0001)。结论：葡萄糖胺和鱼油联用能够降低尿石症发病风险。
Objective: To investigate the association between glucosamine and fish oil with the risk of urolithiasis, and to provide dietary guidance for the prevention of urolithiasis. Methods: Approximately 500,000 participants aged 40~69 were recruited from across the United Kingdom through the UK Biobank, and data from publicly available international databases were downloaded for this study. Results: Glucosamine users exhibited a significantly reduced risk of urolithiasis (HR = 0.77, 95% CI: 0.72–0.83, P < 0.0001). Fish oil users also demonstrated a statistically significant reduction in urolithiasis risk in both age-adjusted and multivariable-adjusted models (HR = 0.90, 95% CI: 0.84~0.95, P = 0.0006). Participants who used both fish oil and glucosamine showed the strongest protective effect. Compared to non-users, the combined use of these supplements was associated with a significantly lower risk of urolithiasis (HR = 0.83, 95% CI: 0.75~0.90, P < 0.0001). Conclusion: The combined use of glucosamine and fish oil is associated with a reduced risk of urolithiasis.
| [1] | Sorokin, I., Mamoulakis, C., Miyazawa, K., Rodgers, A., Talati, J. and Lotan, Y. (2017) Epidemiology of Stone Disease across the World. World Journal of Urology, 35, 1301-1320. https://doi.org/10.1007/s00345-017-2008-6 |
| [2] | Kachkoul, R., Touimi, G.B., El Mouhri, G., et al. (2023) Urolithiasis: History, Epidemiology, Aetiologic Factors and Management. Malaysian Journal of Pathology, 45, 333-352. |
| [3] | Yitgin, Y., Asrak, H. and Tefik, T. (2023) Role, Importance and Assessment of Dietary Habits in Urolithiasis Patient. World Journal of Urology, 41, 1229-1233. https://doi.org/10.1007/s00345-023-04277-3 |
| [4] | Lehrer, S., Morello, T., Karrasch, C., Rheinstein, P.H. and Danias, J. (2024) Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma. Journal of Glaucoma, 33, 240-245. https://doi.org/10.1097/ijg.0000000000002340 |
| [5] | Derwich, M., Górski, B., Amm, E. and Pawłowska, E. (2023) Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review. International Journal of Molecular Sciences, 24, Article 4925. https://doi.org/10.3390/ijms24054925 |
| [6] | Pan, Y., Su, J., Qian, S. and Xu, G. (2024) Impact of Habitual Intake of Glucosamine, Fresh Fruit, and Tea on the Risk of Urolithiasis: A Two-Sample Mendelian Randomization Study. Medicine, 103, e37254. https://doi.org/10.1097/md.0000000000037254 |
| [7] | Rodgers, A.L. and Siener, R. (2020) The Efficacy of Polyunsaturated Fatty Acids as Protectors against Calcium Oxalate Renal Stone Formation: A Review. Nutrients, 12, Article 1069. https://doi.org/10.3390/nu12041069 |
| [8] | Siener, R., Jansen, B., Watzer, B. and Hesse, A. (2011) Effect of N-3 Fatty Acid Supplementation on Urinary Risk Factors for Calcium Oxalate Stone Formation. Journal of Urology, 185, 719-724. https://doi.org/10.1016/j.juro.2010.09.074 |
| [9] | Kantor, E.D., Lampe, J.W., Vaughan, T.L., Peters, U., Rehm, C.D. and White, E. (2012) Association between Use of Specialty Dietary Supplements and C-Reactive Protein Concentrations. American Journal of Epidemiology, 176, 1002-1013. https://doi.org/10.1093/aje/kws186 |
| [10] | Kantor, E.D., Lampe, J.W., Navarro, S.L., Song, X., Milne, G.L. and White, E. (2014) Associations between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation. The Journal of Alternative and Complementary Medicine, 20, 479-485. https://doi.org/10.1089/acm.2013.0323 |
| [11] | Ye, Z., Xia, Y., Zhou, X., Li, B., Yu, W., Ruan, Y., et al. (2022) CXCR4 Inhibition Attenuates Calcium Oxalate Crystal Deposition-Induced Renal Fibrosis. International Immunopharmacology, 107, Article 108677. https://doi.org/10.1016/j.intimp.2022.108677 |
| [12] | Ticinesi, A., Nouvenne, A., Chiussi, G., Castaldo, G., Guerra, A. and Meschi, T. (2020) Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not Just a Gut-Kidney Axis. A Nutritional Perspective. Nutrients, 12, Article 548. https://doi.org/10.3390/nu12020548 |
| [13] | Yuan, T., Xia, Y., Li, B., Yu, W., Rao, T., Ye, Z., et al. (2023) Gut Microbiota in Patients with Kidney Stones: A Systematic Review and Meta-Analysis. BMC Microbiology, 23, Article 143. |
| [14] | Baggio, B., Gambaro, G., Zambon, S., Marchini, F., Bassi, A., Bordin, L., et al. (1996) Anomalous Phospholipid N-6 Polyunsaturated Fatty Acid Composition in Idiopathic Calcium Nephrolithiasis. Journal of the American Society of Nephrology, 7, 613-620. https://doi.org/10.1681/asn.v74613 |
| [15] | Rodgers, A., Lewandowski, S., Allie-Hamdulay, S., Pinnock, D., Baretta, G. and Gambaro, G. (2009) Evening Primrose Oil Supplementation Increases Citraturia and Decreases Other Urinary Risk Factors for Calcium Oxalate Urolithiasis. Journal of Urology, 182, 2957-2963. https://doi.org/10.1016/j.juro.2009.08.021 |
