妊娠期D-二聚体显著升高1例并文献复习
A Case Report of Significantly Elevated D-Dimer during Pregnancy with Literature Review

分析青岛大学附属医院收治的1例妊娠期D-二聚体显著升高孕妇的临床资料并进行文献复习，探讨孕期高D-二聚体预防不良妊娠结局的临床管理和决策方法。方法：回顾性分析2024年01月04日青岛大学附属医院收治的1例孕37 + 2周D-二聚体显著升高孕妇的病例资料，并复习国内外相关文献，分析孕期高D-二聚体产生原因、可能发生的不良妊娠结局及预防措施。结果：患者入院后完善相关辅助检查，予抗凝治疗，监测胎心、胎动变化，后D-二聚体逐渐下降并维持稳定，于孕39周经剖宫产终止妊娠。术后产妇及新生儿病情稳定。新生儿生后Apgar评分1、5分钟均10分，产妇宫缩好，阴道流血少，术后恢复良好出院。出院后新生儿生长发育与同龄儿无明显差异。通过复习国内外文献资料，了解妊娠期及产褥期D-二聚体区间及高D-二聚体孕妇不良妊娠结局预防措施。
The clinical data of a pregnant woman with a significant increase in D-dimer during pregnancy admitted to the Affiliated Hospital of Qingdao University were analyzed and the literature was reviewed to explore the clinical management and decision-making methods of high D-dimer during pregnancy to prevent adverse pregnancy outcomes. Methods: The case data of a pregnant woman with a significant increase in D-dimer at 37 + 2 weeks gestation admitted to the Affiliated Hospital of Qingdao University on January 04, 2024 were retrospectively analyzed, and relevant literature at home and abroad were reviewed to analyze the causes of high D-dimer during pregnancy, possible adverse pregnancy outcomes and preventive measures. Results: After admission, the relevant auxiliary examination was completed, anticoagulant treatment was given, fetal heart rate and fetal movement were monitored, D-dimer gradually decreased and remained stable, and pregnancy was terminated by cesarean section at 39 weeks of gestation. The condition of the mother and newborn was stable after the operation. The Apgar score of the newborn was 10 points at 1 and 5 minutes after birth. The puerperal contraction was good, the vaginal bleeding was less, and the postoperative recovery was good. After discharge, there was no significant difference between the growth and development of newborns and those of the same age. Through reviewing the literature at home and abroad, to understand the D-dimer interval during pregnancy and the puerperal period and the prevention measures of adverse pregnancy outcome in pregnant women with high D-dimer.