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自噬依赖性铁死亡在肝细胞癌中的治疗潜力
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Abstract:
肝细胞癌作为一种高发恶性肿瘤，其临床治疗面临诸多瓶颈。尽管索拉非尼作为首个获得批准的晚期肝癌一线靶向治疗药物，但耐药性及毒副作用限制了其临床应用。近年来，铁死亡这一新型的细胞死亡模式在肝细胞癌的治疗领域呈现出一定的优势。铁死亡是一种非凋亡细胞死亡新方式，主要通过脂质活性氧的累积而诱发。自噬与铁死亡之间存在着错综复杂的相互作用关系，相关研究显示，自噬依赖性铁死亡借助铁蛋白自噬、脂噬等路径，在肝细胞癌的发生与发展进程中起到重要的作用。现就自噬依赖性铁死亡的生化过程和作用机制及其在肝细胞癌的研究进展进行综述，为肝细胞癌的治疗提供新的方法和思路。
Hepatocellular carcinoma (HCC) is a highly prevalent malignant tumor, and its clinical treatment encounters many bottlenecks. Although sorafenib, the first approved first-line targeted therapy drug for advanced liver cancer, has limitations in clinical application due to drug resistance and toxic side effects. Ferroptosis, a novel cell death mode, has shown certain advantages in the treatment of HCC. Ferroptosis is a new non-apoptotic cell death mode that is mainly induced by the accumulation of lipid reactive oxygen species. There is a complex interaction between autophagy and ferroptosis. Relevant studies have shown that autophagy-dependent ferroptosis plays an important role in the occurrence and development of HCC through pathways such as ferroptosis and lipophagy. This article reviews the biochemical process and mechanism of autophagy-dependent ferroptosis and its research progress in HCC, providing new methods and ideas for the treatment of HCC.
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