Introduction: viral hepatitis B is a major public health problem. The objective of this study was to determine the prevalence of HBsAgat the laboratory of the Biomedical Analysis Laboratory Society of Guinea (SOLABGUI). Materials and Methods: it was a retrospective descriptive study from January 1, 2020 to December 31, 2024. It concerned all samples for which HBs antigen was requested during the study period at the SOLABGUI laboratory. Results: we listed a total of 2000 bulletins for which HBsAg was requested. We obtained 390 HBsAg positive bulletins, representing a prevalence of 19.5%. Men were the most represented with a frequency of 63.59% (n = 248) with a sex ratio M/F equal to 1.74. The average age of our patients was 22 ± 4 years with extremes of 1 and 80 years. The age group of 31 - 40 years was the most affected with a frequency of 30.77% (n = 120) followed by that over 50 years with a frequency of 23.85% (n = 93) and that of 21 - 30 years with a frequency of 17.69% (n = 69). Merchants and civil servants were the most represented with an identical frequency of 18.46% (n = 72). Married people were the most affected with a frequency of 59.49% (n = 232), single people 40.51% (n = 158). HBV co-infections with HIV and HCV were 2.22% and 1.54% respectively. Conclusion: the prevalence of hepatitis B is considerable and confirms that our country belongs to the area of high endemicity of hepatitis B virus infection.
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