Patient with locally advancer pancreatic cancer was treated with neoadjuvant chemotherapy and chemo-radiation. Surveillance scans showed a left pelvic mass. Since the radiological findings were suggestive of a second primary, she underwent surgery and was found to have bilateral ovarian pancreatic cancer metastasis. The case is being reported to draw attention to this rare oligometastatic presentation that could be treated with curative intent.
References
[1]
Kubeček, O., Laco, J., Špaček, J., Petera, J., Kopecký, J., Kubečková, A., et al. (2017) The Pathogenesis, Diagnosis, and Management of Metastatic Tumors to the Ovary: A Comprehensive Review. Clinical&ExperimentalMetastasis, 34, 295-307. https://doi.org/10.1007/s10585-017-9856-8
[2]
Levine, J.M., Rompen, I.F., Franco, J.C., Swett, B., Kryschi, M.C., Habib, J.R., et al. (2024) The Impact of Metastatic Sites on Survival Rates and Predictors of Extended Survival in Patients with Metastatic Pancreatic Cancer. Pancreatology, 24, 887-893. https://doi.org/10.1016/j.pan.2024.06.004
[3]
Seidman, J.D., Kurman, R.J. and Ronnett, B.M. (2003) Primary and Metastatic Mucinous Adenocarcinomas in the Ovaries Incidence in Routine Practice with a New Approach to Improve Intraoperative Diagnosis. The American Journal of Surgical Pathology, 27, 985-993.
[4]
Lee, K.R. and Young, R.H. (2003) The Distinction between Primary and Metastatic Mucinous Carcinomas of the Ovary Gross and Histologic Findings in 50 Cases. The American Journal of Surgical Pathology, 27, 281-292.
[5]
Yemelyanova, A.V., Vang, R., Judson, K., Wu, L. and Ronnett, B.M. (2008) Distinction of Primary and Metastatic Mucinous Tumors Involving the Ovary: Analysis of Size and Laterality Data by Primary Site with Reevaluation of an Algorithm for Tumor Classification. The American Journal of Surgical Pathology, 32, 128-138.
[6]
Young, R.H. and Hart, W.R. (1989) Metastases from Carcinomas of the Pancreas Simulating Primary Mutinous Tumors of the Ovary: A Report of Seven Cases. The American Journal of Surgical Pathology, 13, 748-756.
[7]
Young, R.H., et al. (2006) Krukenberg Tumors of the Ovary: A Clinicopathologic Analysis of 120 Cases with Emphasis on Their Variable Pathologic Manifestations. The American Journal of Surgical Pathology, 30, 277-299.
[8]
Chang, T., Changchien, C., Tseng, C., Lai, C., Tseng, C., Lin, S., et al. (1997) Retrograde Lymphatic Spread: A Likely Route for Metastatic Ovarian Cancers of Gastrointestinal Origin. Gynecologic Oncology, 66, 372-377.
[9]
Habib, J.R., Pasha, S., Khan, S., Kinny‐Köster, B., Shoucair, S., Thompson, E.D., et al. (2021) Ovarian Metastasis from Pancreatic Ductal Adenocarcinoma. World Journal ofSurgery, 45, 3157-3164. https://doi.org/10.1007/s00268-021-06209-x
[10]
Sal, V., Demirkiran, F., Topuz, S., Kahramanoglu, I., Yalcin, I., Bese, T., et al. (2016) Surgical Treatment of Metastatic Ovarian Tumors from Extragenital Primary Sites. InternationalJournalofGynecologicalCancer, 26, 688-696. https://doi.org/10.1097/igc.0000000000000673
[11]
Kim, W.Y., Kim, T., Kim, S.E., Lee, J., Lee, J., Kim, B., et al. (2010) The Role of Cytoreductive Surgery for Non-Genital Tract Metastatic Tumors to the Ovaries. EuropeanJournalofObstetrics&GynecologyandReproductiveBiology, 149, 97-101. https://doi.org/10.1016/j.ejogrb.2009.11.011
[12]
Wang, S., Zhu, L., Wu, H., Dai, M. and Zhao, Y. (2020) Pancreatic Cancer with Ovarian Metastases: A Case Report and Review of the Literature. WorldJournalofClinicalCases, 8, 5380-5388. https://doi.org/10.12998/wjcc.v8.i21.5380
[13]
van Driel, W.J., Koole, S.N., Sikorska, K., Schagen van Leeuwen, J.H., Schreuder, H.W.R., Hermans, R.H.M., et al. (2018) Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. NewEnglandJournalofMedicine, 378, 230-240. https://doi.org/10.1056/nejmoa1708618
