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中医药基于铁死亡相关的信号通路治疗帕金森病研究进展
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Abstract:
PD是一种神经退行性病变疾病，发病率随年龄增长而上升，全球人口老龄化加剧，帕金森病患者数量也在增加。PD主要的病理变化是多巴胺能神经元的损伤和路易体的堆积，近年来，铁死亡作为非凋亡性细胞死亡方式，被发现与PD病理发展密切相关。PD是中医中的颤证，其基本病机为肝风内动，筋脉失养，中医药也越来越多应用于PD的治疗，研究发现中药通过调控铁死亡通路治疗PD具有可观的效果，这可能与抗氧化应激、保护神经元免受损伤有关。中医药可能通过调节Nrf2因子相关通路、p53/SLC7A11通路、ACLS4/GPX4通路和调节NCOA4介导的铁自噬来抑制铁死亡治疗PD。
PD is a neurodegenerative disease with an increasing incidence of disease, and the number of patients with Parkinson’s disease is increasing as the global population ages. The main pathological changes of PD are the damage of dopaminergic neurons and the accumulation of Lewy bodies, and in recent years, ferroptosis, as a non-apoptotic cell death mode, has been found to be closely related to the pathological development of PD. PD is a fibrillation syndrome in traditional Chinese medicine, and its basic pathogenesis is liver wind internal movement, tendon and vein dystrophy, and traditional Chinese medicine is also increasingly used in the treatment of PD, and studies have found that traditional Chinese medicine has considerable effects in the treatment of PD by regulating the ferroptosis pathway, which may be related to antioxidative stress and protection of neurons from damage. TCM may inhibit ferroptosis in the treatment of PD by modulating the Nrf2 factor-related pathway, p53/SLC7A11 pathway, ACLS4/GPX4 pathway, and regulating NCOA4-mediated iron autophagy.
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