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精准医学背景下结直肠息肉临床研究进展
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Abstract:
结直肠息肉是结直肠癌的病理前驱病变，涉及遗传变异、表观遗传调控、微生物代谢失衡及免疫炎症异常，精准医学为其提供个体化防治策略。本文分析遗传因素、生活方式、环境暴露及免疫机制对息肉发生的影响，探讨基于基因组学、转录组学、蛋白质组学及代谢组学的分子机制，梳理精准筛查、靶向干预、免疫调节及环境控制等个体化治疗措施，构建数字化健康管理模式，优化结直肠息肉的精准诊疗路径，为临床实践提供理论支撑，推动精准医学在消化疾病防治领域的应用。
Colorectal polyps are pathological prodromal lesions of colorectal cancer, involving genetic variation, epigenetic regulation, microbial metabolism imbalance and immune inflammation abnormalities, and precision medicine provides individualized prevention and treatment strategies for them. This article analyzes the effects of genetic factors, lifestyle, environmental exposure and immune mechanisms on the occurrence of polyps, discusses the molecular mechanisms based on genomics, transcriptomics, proteomics and metabolomics, sorts out individualized treatment measures such as precision screening, targeted intervention, immune regulation and environmental control, constructs a digital health management model, optimizes the precise diagnosis and treatment path of colorectal polyps, provides theoretical support for clinical practice, and promotes the application of precision medicine in the field of digestive disease prevention and treatment.
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