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Health  2025 

Evaluation of the Hair Growth-Promoting Effects of Combined Treatment with Hair Growth Stimulants

DOI: 10.4236/health.2025.174028, PP. 425-449

Keywords: Hair Growth Products, AGA, Hair Growth

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Abstract:

The number of people with hair loss and thinning hair is increasing in Japan, regardless of age or sex, due to the aging of the population, advancement of women into the workforce, and increase in social stress. Hair loss and thinning have been attributed to genetic predisposition and hormonal imbalance; however, recent research has explored their relationship with environmental and psychological stress. Since 1981, we have been providing treatments focused on growing and nurturing hair in Japan, with the number of patients exceeding 2000 per year. We have conducted research on hair growth and regrowth for 40 years, focusing on factors such as hormonal imbalance, sebum, and stress, based on findings from our specialized manual treatments. In recent years, the number of patients taking finasteride has increased, and we have developed a treatment strategy to maximize its effectiveness. However, some patients either do not respond to the treatment or may not require the use of finasteride. In this study, we report on 1) cases in which efficacy was confirmed with manual treatment alone, 2) cases in which efficacy was confirmed with finasteride and manual treatment, 3) cases that did not respond to manual treatment and finasteride, and 4) cases with confirmed efficacy with continued treatment after discontinuation of finasteride.

References

[1]  Yoshino, T. (2005) Estrogen Controls the Expression of BMP-2 Gene through Beta-Type Estrogen Receptor. Fragrance Journal: Research & Development for Cosmetics, Toiletries & Allied Industries, 33, 31-35. (In Japanese)
[2]  Banno, N. and Tsuda, Y. (2005) Promotion of Hair Growth by JIOU with the Combination of Antiandrogenic Effect and Improved Blood Circulation. Fragrance Journal: Research & Development for Cosmetics, Toiletries & Allied Industries, 33, 73-78.
[3]  Arck, P.C., Slominski, A., Theoharides, T.C., Peters, E.M.J. and Paus, R. (2006) Neuroimmunology of Stress: Skin Takes Center Stage. Journal of Investigative Dermatology, 126, 1697-1704.
https://doi.org/10.1038/sj.jid.5700104
[4]  Ito, N., Sugawara, K., Bodó, E., Takigawa, M., van Beek, N., Ito, T., et al. (2010) Corticotropin-Releasing Hormone Stimulates the in Situ Generation of Mast Cells from Precursors in the Human Hair Follicle Mesenchyme. Journal of Investigative Dermatology, 130, 995-1004.
https://doi.org/10.1038/jid.2009.387
[5]  Drake, L.A., Dinehart, S.M., Farmer, E.R., Goltz, R.W., Graham, G.F., Hordinsky, M.K., Lewis, C.W., et al. (1996) Guidelines of Care for Androgenetic Alopecia. Journal of the American Academy of Dermatology, 35, 465-469.
[6]  Olsen, E.A., Messenger, A.G., Shapiro, J., Bergfeld, W.F., Hordinsky, M.K., Roberts, J.L., et al. (2005) Evaluation and Treatment of Male and Female Pattern Hair Loss. Journal of the American Academy of Dermatology, 52, 301-311.
https://doi.org/10.1016/j.jaad.2004.04.008
[7]  Olsen, E.A. (2003) Current and Novel Methods for Assessing Efficacy of Hair Growth Promoters in Pattern Hair Loss. Journal of the American Academy of Dermatology, 48, 253-262.
https://doi.org/10.1067/mjd.2003.81
[8]  Ogata, T. (1953) Development of Patterned Alopecia. Sogo Rinsho, 2, 101-106. (In Japanese)
[9]  Hamilton, J.B. (1942) Male Hormone Stimulation Is Prerequisite and an Incitant in Common Baldness. American Journal of Anatomy, 71, 451-480.
https://doi.org/10.1002/aja.1000710306
[10]  Severi, G., Sinclair, R., Hopper, J.L., English, D.R., McCredie, M.R.E., Boyle, P., et al. (2003) Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors. British Journal of Dermatology, 149, 1207-1213.
https://doi.org/10.1111/j.1365-2133.2003.05565.x
[11]  Itami, S. (2004) Pathomechanism of Androgenetic Alopecia and New Treatment. Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 41, 598-600.
https://doi.org/10.3143/geriatrics.41.598
[12]  Inui, S. and Itami, S. (2012) Androgen Actions on the Human Hair Follicle: Perspectives. Experimental Dermatology, 22, 168-171.
https://doi.org/10.1111/exd.12024
[13]  Li, R., Brockschmidt, F.F., Kiefer, A.K., Stefansson, H., Nyholt, D.R., Song, K., et al. (2012) Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases. PLOS Genetics, 8, e1002746.
https://doi.org/10.1371/journal.pgen.1002746
[14]  Yap, C.X., Sidorenko, J., Wu, Y., Kemper, K.E., Yang, J., Wray, N.R., et al. (2018) Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness. Nature Communications, 9, Article No. 5407.
https://doi.org/10.1038/s41467-018-07862-y
[15]  Heath, A.C., Nyholt, D.R., Gillespie, N.A. and Martin, N.G. (2003) Genetic Basis of Male Pattern Baldness. Journal of Investigative Dermatology, 121, 1561-1564.
https://doi.org/10.1111/j.1523-1747.2003.12615.x
[16]  Rexbye, H., Petersen, I., Iachina, M., Mortensen, J., McGue, M., Vaupel, J.W., et al. (2005) Hair Loss among Elderly Men: Etiology and Impact on Perceived Age. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 60, 1077-1082.
https://doi.org/10.1093/gerona/60.8.1077
[17]  Gatherwright, J., Liu, M.T., Amirlak, B., Gliniak, C., Totonchi, A. and Guyuron, B. (2013) The Contribution of Endogenous and Exogenous Factors to Male Alopecia: A Study of Identical Twins. Plastic and Reconstructive Surgery, 131, 794e-801e.
https://doi.org/10.1097/prs.0b013e3182865ca9
[18]  Manabe, M., Tsuboi, R., Itami, S., Nagata, S., Amaha, Y., Ito, T., Inui, S., et al. (2017) Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss. The Journal of Dermatology, 127, 2763-2777. (In Japanese)
[19]  Drake, L., Hordinsky, M., Fiedler, V., Swinehart, J., Unger, W.P., Cotterill, P.C., et al. (1999) The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia. Journal of the American Academy of Dermatology, 41, 550-554.
https://doi.org/10.1016/s0190-9622(99)80051-6
[20]  Olsen, E.A., Hordinsky, M., Whiting, D., Stough, D., Hobbs, S., Ellis, M.L., et al. (2006) The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride versus Finasteride. Journal of the American Academy of Dermatology, 55, 1014-1023.
https://doi.org/10.1016/j.jaad.2006.05.007
[21]  Otomo, S. (2002) Hair Growth Effect of Minoxidil. Folia Pharmacologica Japonica, 119, 167-174.
https://doi.org/10.1254/fpj.119.167
[22]  Chanprapaph, K., Sutharaphan, T. and Suchonwanit, P. (2021) Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls. Clinical Interventions in Aging, 16, 781-787.
https://doi.org/10.2147/cia.s310178
[23]  Sakamoto, T., Nakamura, M. and Nakano, M. (1994) A Genetic Study on Female Hormones and Hair Thinning. Fragrance Journal: Research & Development for Cosmetics, Toiletries & Allied Industries, 22, 65-72. (In Japanese)
[24]  Fukuda, M. (2001) Dermatology in Cosmetic Science. Journal of the Japan Society of Colour Material, 74, 308-316.
https://doi.org/10.4011/shikizai1937.74.308
[25]  Downing, D.T., Strauss, J.S. and Pochi, P.E. (1969) Variability in the Chemical Composition of Human Skin Surface Lipids. Journal of Investigative Dermatology, 53, 322-327.
https://doi.org/10.1038/jid.1969.157
[26]  Jacobsen, E., Billings, J.K., Frantz, R.A., Kinney, C.K., Stewart, M.E. and Downing, D.T. (1985) Age-Related Changes in Sebaceous Wax Ester Secretion Rates in Men and Women. Journal of Investigative Dermatology, 85, 483-485.
https://doi.org/10.1111/1523-1747.ep12277224
[27]  Strauss, J.S. and Pochi, P.E. (1968) The Changes in Human Sebaceous Gland Activity with Age. In: Baccaredda-Boy, A., Moretti, G. and Frey, J.R., Eds., International Symposium, Rapallo, July 1967, Proceedings: “Biopathology of Pattern Alopecia”, Karger, 166-170.
[28]  Pochi, P.E. and Strauss, J.S. (1969) Sebaceous Gland Response in Man to the Administration of Testosterone, Δ4-Androstenedione, and Dehydroisoandrosterone. Journal of Investigative Dermatology, 52, 32-36.
https://doi.org/10.1038/jid.1969.4
[29]  Giltay, E.J. and Gooren, L.J.G. (2000) Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females. The Journal of Clinical Endocrinology & Metabolism, 85, 2913-2921.
https://doi.org/10.1210/jcem.85.8.6710
[30]  Gershbein, L.L. and Baburao, K. (1984) Multiple Discriminant Analysis of Fatty Acids from Male Scalp Hair Lipids. Fette, Seifen, Anstrichmittel, 86, 121-128.
https://doi.org/10.1002/lipi.19840860310
[31]  Okajima, K. (2009) Hair-Growing Effect of a Saliva Component Sialic Acid: The Molecular Mechanism and Possible Therapeutic Application for Alopecia. Fragrance Journal: Research & Development for Cosmetics, Toiletries & Allied Industries, 37, 43-47. (In Japanese)
[32]  Okajima, K. and Harada, N. (2008) Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications. Current Medicinal Chemistry, 15, 3095-3112.
https://doi.org/10.2174/092986708786848604
[33]  Shanshanwal, S.S. and Dhurat, R. (2017) Superiority of Dutasteride over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men with Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study. Indian Journal of Dermatology, Venereology, and Leprology, 83, 47-54.
https://doi.org/10.4103/0378-6323.188652
[34]  Leliefeld, H.H.J., Debruyne, F.M.J. and Reisman, Y. (2023) The Post-Finasteride Syndrome: Possible Etiological Mechanisms and Symptoms. International Journal of Impotence Research.
https://doi.org/10.1038/s41443-023-00759-5
[35]  Lueangarun, S., Visutjindaporn, P. and Parcharoen, Y. (2021) Systematic Review and Meta-Analysis of Randomized Controlled Trials of United States Food and Drug Administration-Approved, Home-Use, Low-Level Light/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology. The Journal of Clinical and Aesthetic Dermatology, 14, E64-E75.
[36]  Pillai, J. and Mysore, V. (2021) Role of Low-Level Light Therapy (LLLT) in Androgenetic Alopecia. Journal of Cutaneous and Aesthetic Surgery, 14, 385-391.
https://doi.org/10.4103/jcas.jcas_218_20
[37]  Egger, A., Resnik, S.R., Aickara, D., Maranda, E., Kaiser, M., Wikramanayake, T.C., et al. (2020) Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature. Skin Appendage Disorders, 6, 259-267.
https://doi.org/10.1159/000509001
[38]  Afifi, L., Maranda, E.L., Zarei, M., Delcanto, G.M., Falto‐Aizpurua, L., Kluijfhout, W.P., et al. (2016) Low‐Level Laser Therapy as a Treatment for Androgenetic Alopecia. Lasers in Surgery and Medicine, 49, 27-39.
https://doi.org/10.1002/lsm.22512
[39]  Revene, A. (2023) Hair Transplant: Procedures, Complications and Tips.
[40]  Arif, T., Dorjay, K., Adil, M. and Sami, M. (2017) Dutasteride in Androgenetic Alopecia: An Update. Current Clinical Pharmacology, 12, 31-35.
https://doi.org/10.2174/1574884712666170310111125
[41]  Zhou, Z., Song, S., Gao, Z., Wu, J., Ma, J. and Cui, Y. (2019) The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis. Clinical Interventions in Aging, 14, 399-406.
https://doi.org/10.2147/cia.s192435
[42]  Gupta, A.K., Talukder, M. and Williams, G. (2022) Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia. Journal of Dermatological Treatment, 33, 2946-2962.
https://doi.org/10.1080/09546634.2022.2109567
[43]  Emer, J. and Lauren Levy, L.L. (2013) Female Pattern Alopecia: Current Perspectives. International Journal of Womens Health, 5, 541-556.
https://doi.org/10.2147/ijwh.s49337
[44]  Johnson, D.B. and Sonthalia, S. (2021) Defibrillation. StatPearls Publishing.
[45]  Shaw, J.C. (1996) Antiandrogen Therapy in Dermatology. International Journal of Dermatology, 35, 770-778.
https://doi.org/10.1111/j.1365-4362.1996.tb02970.x
[46]  Zgonc Škulj, A., Poljšak, N., Kočevar Glavač, N. and Kreft, S. (2019) Herbal Preparations for the Treatment of Hair Loss. Archives of Dermatological Research, 312, 395-406.
https://doi.org/10.1007/s00403-019-02003-x
[47]  Farris, P.K., Rogers, N., McMichael, A. and Kogan, S. (2017) A Novel Multi-Targeting Approach to Treating Hair Loss, Using Standardized Nutraceuticals. Journal of Drugs in Dermatology, 16, s141-s148.
[48]  Stevens, J. and Khetarpal, S. (2019) Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol. International Journal of Womens Dermatology, 5, 46-51.
https://doi.org/10.1016/j.ijwd.2018.08.004
[49]  Gupta, A.K., Cole, J., Deutsch, D.P., Everts, P.A., Niedbalski, R.P., Panchaprateep, R., et al. (2019) Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia. Dermatologic Surgery, 45, 1262-1273.
https://doi.org/10.1097/dss.0000000000001894
[50]  Gentile, P., Garcovich, S., Bielli, A., Scioli, M.G., Orlandi, A. and Cervelli, V. (2015) The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial. Stem Cells Translational Medicine, 4, 1317-1323.
https://doi.org/10.5966/sctm.2015-0107
[51]  Evans, A.G., Mwangi, J.M., Pope, R.W., Ivanic, M.G., Botros, M.A., Glassman, G.E., et al. (2020) Platelet-Rich Plasma as a Therapy for Androgenic Alopecia: A Systematic Review and Meta-Analysis. Journal of Dermatological Treatment, 33, 498-511.
https://doi.org/10.1080/09546634.2020.1770171
[52]  Giordano, S., Romeo, M., di Summa, P., Salval, A. and Lankinen, P. (2018) A Meta-Analysis on Evidence of Platelet-Rich Plasma for Androgenetic Alopecia. International Journal of Trichology, 10, 1-10.
https://doi.org/10.4103/ijt.ijt_74_16
[53]  Panda, B., Sharma, Y., Gupta, S. and Mohanty, S. (2021) Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review. Life, 11, Article No. 784.
https://doi.org/10.3390/life11080784
[54]  Chahla, J., Cinque, M.E., Piuzzi, N.S., Mannava, S., Geeslin, A.G., Murray, I.R., et al. (2017) A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature. Journal of Bone and Joint Surgery, 99, 1769-1779.
https://doi.org/10.2106/jbjs.16.01374
[55]  Kost, Y., Muskat, A., Mhaimeed, N., Nazarian, R.S. and Kobets, K. (2022) Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities. Journal of Cosmetic Dermatology, 21, 3226-3231.
https://doi.org/10.1111/jocd.15008
[56]  Krane, N.A., Christofides, E.A. and Halaas, Y. (2021) Advances in Hair Restoration. Current Otorhinolaryngology Reports, 9, 436-441.
https://doi.org/10.1007/s40136-021-00368-0
[57]  Gupta, A.K., Renaud, H.J. and Halaas, Y. (2020) Exosomes: A New Effective Non-Surgical Therapy for Androgenetic Alopecia? SKINmed, 18, 96-100.
[58]  Huh, C.-H. and Kwon, S.H. (2019) Exosome for Hair Regeneration: From Bench to Bedside. Journal of the American Academy of Dermatology, 81, AB62.
[59]  Yuan, A., Bian, Q. and Gao, J. (2020) Current Advances in Stem Cell-Based Therapies for Hair Regeneration. European Journal of Pharmacology, 881, Article ID: 173197.
https://doi.org/10.1016/j.ejphar.2020.173197
[60]  Food and Drug Administration (2019) Summary Report on Antimicrobials Sold or Distributed for Use in Food-Producing Animals.
[61]  Ocampo‐Garza, S.S., Fabbrocini, G., Ocampo‐Candiani, J., Cinelli, E. and Villani, A. (2020) Micro Needling: A Novel Therapeutic Approach for Androgenetic Alopecia, a Review of Literature. Dermatologic Therapy, 33, e14267.
https://doi.org/10.1111/dth.14267
[62]  Dhurat, R., Sukesh, M., Avhad, G., Dandale, A., Pal, A. and Pund, P. (2013) A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study. International Journal of Trichology, 5, 6-11.
https://doi.org/10.4103/0974-7753.114700
[63]  Faghihi, G., Nabavinejad, S., Mokhtari, F., Fatemi Naeini, F. and Iraji, F. (2020) Microneedling in Androgenetic Alopecia; Comparing Two Different Depths of Microneedles. Journal of Cosmetic Dermatology, 20, 1241-1247.
https://doi.org/10.1111/jocd.13714
[64]  Neerja, P. (2020) A Study on the Efficacy of Microneedling with Minoxidil Solution versus Microneedling with Hair Multivitamin Solution for the Treatment of Androgenetic Alopecia. International Journal of Dermatology and Clinical Research, 6, 10-12.
https://doi.org/10.17352/2455-8605.000037
[65]  Daruwalla, S.B., Dhurat, R.S. and Hamid, S.A.T. (2022) All That a Dermatotrichologist Needs to Know about Hair Camouflage: A Comprehensive Review. International Journal of Trichology, 14, 77-83.
https://doi.org/10.4103/ijt.ijt_6_21
[66]  Saed, S., Ibrahim, O. and Bergfeld, W.F. (2017) Hair Camouflage: A Comprehensive Review. International Journal of Womens Dermatology, 3, S75-S80.
https://doi.org/10.1016/j.ijwd.2017.02.016

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