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卵巢粘液性交界性肿瘤恶变1例并文献复习
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Abstract:
目的:探讨卵巢粘液性交界性肿瘤(mucinous-BOT)恶变的临床病理特征、诊断、治疗及预后,以提高对该疾病的认识和诊治水平。方法:报道1例卵巢粘液性交界性肿瘤恶变的病例,并结合相关文献进行复习。结果:患者为卵巢交界性粘液性肿瘤,囊肿剥除术后复发恶变,预后差。治疗以手术为主,认为保留生育功能的手术应谨慎考虑,完成生育后应考虑行彻底的手术分期。结论:卵巢交界性粘液性肿瘤恶变虽罕见,但预后较差。临床应重视其危险因素,早期诊断和彻底手术是改善预后的关键,术后需密切随访。
Objective: To explore the clinicopathological characteristics, diagnosis, treatment, and prognosis of malignant transformation in ovarian mucinous borderline tumors (mucinous-BOTs), aiming to enhance understanding and improve the management of this condition. Methods: A case of malignant transformation in an ovarian mucinous borderline tumor was reported, and a review of relevant literature was conducted. Results: The patient was diagnosed with an ovarian mucinous borderline tumor that recurred and underwent malignant transformation following cystectomy, resulting in a poor prognosis. Treatment primarily involved surgery, and it was concluded that fertility-sparing surgery should be approached with caution. Complete surgical staging should be considered after childbearing. Conclusion: Although malignant transformation in ovarian mucinous borderline tumors is rare, it carries a poor prognosis. Clinical attention should be given to its risk factors, with early diagnosis and thorough surgery being crucial for improving outcomes. Postoperative follow-up is essential.
[1] | Hauptmann, S., Friedrich, K., Redline, R. and Avril, S. (2016) Ovarian Borderline Tumors in the 2014 WHO Classification: Evolving Concepts and Diagnostic Criteria. Virchows Archiv, 470, 125-142. https://doi.org/10.1007/s00428-016-2040-8 |
[2] | Khunamornpong, S., Settakorn, J., Sukpan, K., Suprasert, P. and Siriaunkgul, S. (2011) Mucinous Tumor of Low Malignant Potential (“Borderline” or “Atypical Proliferative” Tumor) of the Ovary: A Study of 171 Cases with the Assessment of Intraepithelial Carcinoma and Microinvasion. International Journal of Gynecological Pathology, 33, 218-230. https://doi.org/10.1097/pgp.0b013e3181fcf01a |
[3] | Cuatrecasas, M., Villanueva, A., Matias-Guiu, X. and Prat, J. (1997) K-Ras Mutations in Mucinous Ovarian Tumors: A Clinicopathologic and Molecular Study of 95 Cases. Cancer, 79, 1581-1586. https://doi.org/10.1002/(sici)1097-0142(19970415)79:8<1581::aid-cncr21>3.0.co;2-t |
[4] | Khunamornpong, S., et al. (2011) Mucinous Tumor of Low Malignant Potential (“Borderline” or “Atypical Proliferative” Tumor) of the Ovary: A Study of 171 Cases with the Assessment of Intraepithelial Carcinoma and Microinvasion. International Journal of Gynecological Pathology: Official Journal of the International Society of Gynecological Pathologists, 30, 218-230. |
[5] | Vasconcelos, I. and de Sousa Mendes, M. (2015) Conservative Surgery in Ovarian Borderline Tumours: A Meta-Analysis with Emphasis on Recurrence Risk. European Journal of Cancer, 51, 620-631. https://doi.org/10.1016/j.ejca.2015.01.004 |
[6] | Koskas, M., Uzan, C., Gouy, S., Pautier, P., Lhomme, C., Haie-Meder, C., et al. (2011) Fertility Determinants after Conservative Surgery for Mucinous Borderline Tumours of the Ovary (Excluding Peritoneal Pseudomyxoma). Human Reproduction, 26, 808-814. https://doi.org/10.1093/humrep/deq399 |
[7] | Sun, L., Li, N., Song, Y., Wang, G., Zhao, Z. and Wu, L. (2018) Clinicopathologic Features and Risk Factors for Recurrence of Mucinous Borderline Ovarian Tumors: A Retrospective Study with Follow-Up of More than 10 Years. International Journal of Gynecological Cancer, 28, 1643-1649. https://doi.org/10.1097/igc.0000000000001362 |
[8] | Chen, X., Fang, C., Zhu, T., Zhang, P., Yu, A. and Wang, S. (2017) Identification of Factors That Impact Recurrence in Patients with Borderline Ovarian Tumors. Journal of Ovarian Research, 10, Article No. 23. https://doi.org/10.1186/s13048-017-0316-5 |
[9] | Gershenson, D.M. (2017) Management of Borderline Ovarian Tumours. Best Practice & Research Clinical Obstetrics & Gynaecology, 41, 49-59. https://doi.org/10.1016/j.bpobgyn.2016.09.012 |