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肠道菌群调节认知功能障碍的研究进展
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Abstract:
肠道菌群不仅能维持宿主正常生理功能、参与机体衰老进程，而且可以改善大脑健康、调节认知行为。肠道菌群调节认知功能障碍，其潜在机制可能是通过肠道粘膜屏障、肠道菌群代谢产物、免疫系统，以及微生物神经递质等途径，进而影响微生物群–肠–脑轴功能。本文对肠道菌群调节认知功能障碍及潜在机制进行综述，拟为寻找预测和防治认知功能障碍的方法提出新的思路。
A healthy intestinal flora can play a significant role in maintaining physiological function and slowing down the aging process, as well as regulating brain health and enhancing cognitive function. Cognitive dysfunction may be regulated by intestinal flora through the intestinal mucosal barrier, the metabolites of intestinal flora, the immune system or microbial neurotransmitters, thus affecting the function of the microbiota-gut-brain axis. We review the regulation of intestinal flora on cognitive dysfunction and its potential mechanisms, aiming to provide new ideas for the prediction and prevention of cognitive dysfunction.
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