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糖尿病性心肌病代谢紊乱相关研究进展
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Abstract:
糖尿病性心肌病(diabetes cardiomyopathy, DCM)是一类与冠心病、高血压、瓣膜病等无关的特异性心肌病。DCM以心肌代谢紊乱、心肌纤维化及肥大、心肌细胞坏死等病理变化为主要特征，逐渐演变为收缩功能障碍，最终引发心力衰竭死亡。随着糖尿病的患病率的上升，DCM的高致死率受到越来越多的关注。糖脂代谢紊乱与DCM的发生、发展密切相关，目前关于DCM糖脂代谢紊乱方面的相关研究发现，葡萄糖转运体和脂质转运体的相互易位是糖尿病心肌病发病的重要基础。本文主要从糖脂代谢紊乱这一视角出发，对糖尿病性心肌病发病机制的最新研究进展进行系统性综述。
Diabetic cardiomyopathy (DCM) is a kind of specific cardiomyopathy that has nothing to do with coronary heart disease, hypertension and valvular disease. DCM is mainly characterized by pathological changes such as myocardial metabolism disorder, myocardial fibrosis and hypertrophy, and myocardial cell necrosis, which gradually evolves into systolic dysfunction and eventually leads to heart failure and death. With the increasing prevalence of diabetes mellitus, the high fatality rate of DCM has attracted more and more attention. The disorder of glucose and lipid metabolism plays an important role in the pathogenesis of DCM. Current studies on the disorder of glucose and lipid metabolism in DCM have found that the mutual translocation of glucose transporters and lipid transporters is an important basis for the pathogenesis of diabetic cardiomyopathy. In this paper, the latest research progress on the pathogenesis of diabetic cardiomyopathy was systematically reviewed from the perspective of the disorder of glucose and lipid metabolism.
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