In clinical practice, the incidence of venous thrombosis associated with Peripherally Inserted Central Catheters (PICCs) is notably high. However, there is limited literature addressing the related nursing measures for this complication. This article provides a comprehensive review of the mechanisms, treatment options, and nursing interventions for catheter-related thrombosis. By enhancing clinical nurses’ understanding of this condition, the review aims to contribute to reducing the incidence of venous thrombosis and improving patient outcomes.
References
[1]
Pan, L., Zhao, Q. and Yang, X. (2014) Risk Factors for Venous Thrombosis Associated with Peripherally Inserted Central Venous Catheters. International Journal of Clinical Experimental Medicine, 7, 5814-5819.
[2]
Xing, L., Adhikari, V.P., Liu, H., Kong, L.Q., Liu, S.C., Li, H.Y., et al. (2012) Diagnosis Prevention and Treatment for PICC‐Related Upper Extremity Deep Vein Thrombosis in Breast Cancer Patients. Asia-Pacific Journal of Clinical Oncology, 8, e12-e16. https://doi.org/10.1111/j.1743-7563.2011.01508.x
[3]
Yi, X., Chen, J., Li, J., Feng, L., Wang, Y., Zhu, J., et al. (2014) Risk Factors Associated with PICC-Related Upper Extremity Venous Thrombosis in Cancer Patients. Journal of Clinical Nursing, 23, 837-843. https://doi.org/10.1111/jocn.12227
[4]
Wang, P., He, L., Yuan, Q., Lu, J., Ji, Q., Peng, A., et al. (2024) Risk Factors for Peripherally Inserted Central Catheter-Related Venous Thrombosis in Adult Patients with Cancer. Thrombosis Journal, 22, Article No. 6. https://doi.org/10.1186/s12959-023-00574-4
[5]
Esmon, C.T. (2009) Basic Mechanisms and Pathogenesis of Venous Thrombosis. Blood Reviews, 23, 225-229. https://doi.org/10.1016/j.blre.2009.07.002
[6]
Li, X., Guo, T., Feng, Q., Bai, T., Wu, L., Liu, Y., et al. (2022) Progress of Thrombus Formation and Research on the Structure-Activity Relationship for Antithrombotic Drugs. European Journal of Medicinal Chemistry, 228, Article ID: 114035. https://doi.org/10.1016/j.ejmech.2021.114035
[7]
Wang, T., Chen, Q., Deng, J., Li, S., Xu, Y. and Ma, S. (2024) Research Progress on Venous Thrombosis Development in Patients with Malignant Tumors. World Journal of Clinical Cases, 12, 1900-1908. https://doi.org/10.12998/wjcc.v12.i11.1900
[8]
Einstein, M.H., Pritts, E.A. and Hartenbach, E.M. (2007) Venous Thromboembolism Prevention in Gynecologic Cancer Surgery: A Systematic Review. Gynecologic Oncology, 105, 813-819. https://doi.org/10.1016/j.ygyno.2007.03.004
[9]
Nielsen, H.K., Husted, S.E., Krusell, L.R., Fasting, H., Charles, P., Hansen, H.H., et al. (1994) Anticoagulant Therapy in Deep Venous Thrombosis. A Randomized Controlled Study. Thrombosis Research, 73, 215-226. https://doi.org/10.1016/0049-3848(94)90100-7
[10]
Lloyd, N.S., Douketis, J.D., Moinuddin, I., Lim, W. and Crowther, M.A. (2008) Anticoagulant Prophylaxis to Prevent Asymptomatic Deep Vein Thrombosis in Hospitalized Medical Patients: A Systematic Review and Meta-Analysis. Journal of Thrombosis and Haemostasis, 6, 405-414. https://doi.org/10.1111/j.1538-7836.2007.02847.x
[11]
Foley, W., Middleton, W., Lawson, T., Erickson, S., Quiroz, F. and Macrander, S. (1989) Color Doppler Ultrasound Imaging of Lower-Extremity Venous Disease. American Journal of Roentgenology, 152, 371-376. https://doi.org/10.2214/ajr.152.2.371
[12]
van den Borne, H., van der Kolk, M., de Wild, P., Janssen, G., van Uum, S. and van der Graaf, F. (2000) Exclusion of Deep Venous Thrombosis with D-Dimer Testing. Thrombosis and Haemostasis, 83, 191-198. https://doi.org/10.1055/s-0037-1613784
[13]
Goodacre, S., Sampson, F.C., Sutton, A.J., Mason, S. and Morris, F. (2005) Variation in the Diagnostic Performance of D-Dimer for Suspected Deep Vein Thrombosis. QJM: An International Journal of Medicine, 98, 513-527. https://doi.org/10.1093/qjmed/hci085
[14]
Zochios, V., Umar, I., Simpson, N. and Jones, N. (2014) Peripherally Inserted Central Catheter (PICC)-Related Thrombosis in Critically Ill Patients. The Journal of Vascular Access, 15, 329-337. https://doi.org/10.5301/jva.5000239
[15]
Horne, M.K., Mayo, D.J., Cannon, R.O., Chen, C.C., Shawker, T.H. and Chang, R. (2000) Intraclot Recombinant Tissue Plasminogen Activator in the Treatment of Deep Venous Thrombosis of the Lower and Upper Extremities. The American Journal of Medicine, 108, 251-255. https://doi.org/10.1016/s0002-9343(99)00407-6
[16]
Barnes, D.M., Wakefield, T.W. and Rectenwald, J.E. (2008) Novel Biomarkers Associated with Deep Venous Thrombosis: A Comprehensive Review. Biomarker Insights, 3, 93-100. https://doi.org/10.1177/117727190800300004
[17]
Jeon, E.Y. (2011) Interventional Treatment of Deep Vein Thrombosis. Hanyang Medical Reviews, 31, 32-37. https://doi.org/10.7599/hmr.2011.31.1.32
[18]
Houghton, D.E., Billett, H.H., Gaddh, M., Onadeko, O., George, G., Wang, T., et al. (2021) Risk of Pulmonary Emboli after Removal of an Upper Extremity Central Catheter Associated with a Deep Vein Thrombosis. Blood Advances, 5, 2807-2812. https://doi.org/10.1182/bloodadvances.2021004698
[19]
Ibarra-Pérez, C., Lau-Cortés, E., Colmenero-Zubiate, S., Arévila-Ceballos, N., Humberto Fong, J., Sánchez-Martínez, R., et al. (1988) Prevalence and Prevention of Deep Venous Thrombosis of the Lower Extremities in High-Risk Pulmonary Patients. Angiology, 39, 505-513. https://doi.org/10.1177/000331978803900603
[20]
Strijkers, R.H.W., Ten Cate-Hoek, A.J., Bukkems, S.F.F.W. and Wittens, C.H.A. (2011) Management of Deep Vein Thrombosis and Prevention of Post-Thrombotic Syndrome. BMJ, 343, d5916. https://doi.org/10.1136/bmj.d5916
[21]
Kim, J.H., Lim, K. and Gwak, H.S. (2017) New Anticoagulants for the Prevention and Treatment of Venous Thromboembolism. Biomolecules & Therapeutics, 25, 461-470. https://doi.org/10.4062/biomolther.2016.271
[22]
Handoll, H.H., Farrar, M.J., McBirnie, J., Tytherleigh-Strong, G.M., Milne, A.A. and Gillespie, W.J. (2002) Heparin, Low Molecular Weight Heparin and Physical Methods for Preventing Deep Vein Thrombosis and Pulmonary Embolism Following Surgery for Hip Fractures. Cochrane Database of Systematic Reviews, No. 4, Article No. CD000305. https://doi.org/10.1002/14651858.cd000305
[23]
Johnston, A., Hsieh, S., Carrier, M., Kelly, S.E., Bai, Z., Skidmore, B., et al. (2018) A Systematic Review of Clinical Practice Guidelines on the Use of Low Molecular Weight Heparin and Fondaparinux for the Treatment and Prevention of Venous Thromboembolism: Implications for Research and Policy Decision-Making. PLOS ONE, 13, e0207410. https://doi.org/10.1371/journal.pone.0207410
[24]
Aujesky, D., Beer, J.H., Mazzolai, L., Baldi, T., Banyai, M., Hayoz, D., et al. (2016) Rivaroxaban for the Treatment of Venous Thromboembolism. Thrombosis and Haemostasis, 116, 472-479. https://doi.org/10.1160/th16-03-0209
[25]
Harder, S. (2014) Pharmacokinetic and Pharmacodynamic Evaluation of Rivaroxaban: Considerations for the Treatment of Venous Thromboembolism. Thrombosis Journal, 12, Article No. 22. https://doi.org/10.1186/1477-9560-12-22
[26]
Schulman, S. (2003) Care of Patients Receiving Long-Term Anticoagulant Therapy. New England Journal of Medicine, 349, 675-683. https://doi.org/10.1056/nejmcp025373
[27]
Xu, L., Fu, C., Zhang, Q., He, C. and Wei, Q. (2021) The Effectiveness of Exercise Training in Treating Venous Thromboembolism: A Systematic Review. The Physician and Sportsmedicine, 49, 1-11. https://doi.org/10.1080/00913847.2020.1786746
[28]
Yan, X.X., Chen, B. and Mao, Y.J. (2022) The Effect of Routine Health Exercises on the Prevention of Lower Extremity Deep Vein Thrombosis Following Pneumonectomy. Ethiopian Journal of Health Development, 36, 1-6.
[29]
Thibert, A., Briche, N., Vernizeau, B.D., Mougin-Guillaume, F. and Béliard, S. (2022) Systematic Review of Adapted Physical Activity and Therapeutic Education of Patients with Chronic Venous Disease. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 10, 1385-1400. https://doi.org/10.1016/j.jvsv.2022.05.004
[30]
Caggiati, A., De Maeseneer, M., Cavezzi, A., Mosti, G. and Morrison, N. (2018) Rehabilitation of Patients with Venous Diseases of the Lower Limbs: State of the Art. Phlebology: The Journal of Venous Disease, 33, 663-671. https://doi.org/10.1177/0268355518754463
[31]
Li, Y., Huang, L., Hou, J. and Hu, D. (2024) Impact of Stage-Specific Limb Function Exercises Guided by a Self-Management Education Model on Arteriovenous Fistula Maturation Status. World Journal of Clinical Cases, 12, 2316-2323. https://doi.org/10.12998/wjcc.v12.i14.2316
[32]
Zhu, S., Song, Y., Chen, X. and Qian, W. (2018) Traditional Chinese and Western Medicine for the Prevention of Deep Venous Thrombosis after Lower Extremity Orthopedic Surgery: A Meta-Analysis of Randomized Controlled Trials. Journal of Orthopaedic Surgery and Research, 13, Article No. 79. https://doi.org/10.1186/s13018-018-0785-2
[33]
Chang, Y., Li, F., Wang, W., Song, L., Li, L., Li, Z., et al. (2015) Integrated Treatment for Lower-Limb Stage II Thromboangiitis Obliterans by Interventional Therapy and Oral Administration of Chinese Medicine: A Randomized Controlled Clinical Trial. Journal of Traditional Chinese Medicine, 35, 41-46. https://doi.org/10.1016/s0254-6272(15)30007-8