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MicroRNA在胃癌中的研究进展及临床价值
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Abstract:
胃癌是全球最常见的癌症之一，严重威胁人类健康。其发病率和死亡率在全球范围内居高不下，特别是在东亚地区，包括中国、日本和韩国等国家。尽管近年来随着医疗技术的进步和治疗手段的创新，胃癌的诊疗水平有所提高，但胃癌的早期诊断仍然面临挑战，许多患者在确诊时已处于晚期，治疗效果不佳，预后较差。因此，深入研究胃癌的发病机制和寻找有效的早期诊断标志物及治疗靶点对于提高胃癌患者的生存率及改善预后具有重要意义。MicroRNA (miRNA)作为一类重要的非编码RNA，大量研究表明其在胃癌的发生、发展过程中发挥着重要作用，近年来已成为胃癌研究的热点之一。本综述旨在总结胃癌相关miRNA的研究进展，并探讨其在胃癌诊断、治疗及预后评估中的潜在应用价值。
Gastric cancer is one of the most common cancers in the world and poses a serious threat to human health. Its morbidity and mortality rates remain high worldwide, especially in East Asia, including countries such as China, Japan, and South Korea. Although the diagnosis and treatment of gastric cancer have improved with the advancement of medical technology and the innovation of treatment methods in recent years, the early diagnosis of gastric cancer is still facing challenges, and many patients are already at an advanced stage when they are diagnosed, with poor treatment effects and poor prognosis. Therefore, it is of great significance to study the pathogenesis of gastric cancer and find effective early diagnostic markers and therapeutic targets to improve the survival rate and prognosis of gastric cancer patients. As an important class of non-coding RNAs, MicroRNAs (miRNAs) have been shown to play an important role in the occurrence and development of gastric cancer, and have become one of the hotspots in gastric cancer research in recent years. The purpose of this review is to summarize the research progress of miRNAs related to gastric cancer and explore their potential application value in the diagnosis, treatment and prognosis evaluation of gastric cancer.
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