|
|
肝源性干细胞在肝脏疾病中的治疗研究进展综述
|
Abstract:
肝脏疾病是一种常见的发病率和死亡率较高的一类疾病。目前，针对肝脏疾病的治疗方法包括手术切除、放疗和化疗等，然而这些治疗方法存在一定的副作用和限制。近年来，干细胞移植作为一种新兴的治疗策略，为终末期肝病患者带来了新的希望。本文将综述肝源性干细胞在肝脏疾病中的治疗应用，讨论其疗效、作用机制及存在的问题，并展望其在临床上的应用前景。
Liver disease is a common disease with high incidence and mortality. Currently, the treatment methods for liver diseases include surgical resection, radiotherapy and chemotherapy, but these treatment methods have certain side effects and limitations. In recent years, stem cell transplantation has brought new hope to patients with end-stage liver disease as an emerging treatment strategy. This article reviews the therapeutic applications of liver-derived stem cells in liver diseases, discusses their therapeutic effects, mechanisms of action and existing problems, and looks forward to their clinical application prospects.
| [1] | Moon, D. and Lee, S. (2009) Liver Transplantation. Gut and Liver, 3, 145-165. https://doi.org/10.5009/gnl.2009.3.3.145 |
| [2] | Lantieri, L., Grimbert, P., Ortonne, N., Suberbielle, C., Bories, D., Gil-Vernet, S., et al. (2016) Face Transplant: Long-Term Follow-Up and Results of a Prospective Open Study. The Lancet, 388, 1398-1407. https://doi.org/10.1016/s0140-6736(16)31138-2 |
| [3] | 黄贵才, 罗业浩, 江慧容, 等. 干细胞对肝脏疾病的临床治疗前景与研究现状[J]. 中国组织工程研究, 2023, 27(19): 3091-3098. |
| [4] | Tanaka, K., Soto-Gutierrez, A., Navarro-Alvarez, N., Rivas-Carrillo, J.D., Jun, H. and Kobayashi, N. (2006) Functional Hepatocyte Culture and Its Application to Cell Therapies. Cell Transplantation, 15, 855-864. https://doi.org/10.3727/000000006783981332 |
| [5] | Denker, H. (2006) Potentiality of Embryonic Stem Cells: An Ethical Problem Even with Alternative Stem Cell Sources. Journal of Medical Ethics, 32, 665-671. https://doi.org/10.1136/jme.2005.014738 |
| [6] | Yu, Y., Wang, X. and Nyberg, S. (2014) Potential and Challenges of Induced Pluripotent Stem Cells in Liver Diseases Treatment. Journal of Clinical Medicine, 3, 997-1017. https://doi.org/10.3390/jcm3030997 |
| [7] | 赵亮, 戴朝六. 肝干细胞在肝再生及肝脏疾病中的研究进展[J]. 肝胆外科杂志, 2018, 26(6): 476-479. |
| [8] | Fausto, N. and Campbell, J.S. (2003) The Role of Hepatocytes and Oval Cells in Liver Regeneration and Repopulation. Mechanisms of Development, 120, 117-130. https://doi.org/10.1016/s0925-4773(02)00338-6 |
| [9] | Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., et al. (2011) Fate Tracing of Mature Hepatocytes in Mouse Liver Homeostasis and Regeneration. Journal of Clinical Investigation, 121, 4850-4860. https://doi.org/10.1172/jci59261 |
| [10] | Bi, Y., Li, J., Yang, Y., Wang, Q., Wang, Q., Zhang, X., et al. (2019) Human Liver Stem Cells Attenuate Concanavalin A-Induced Acute Liver Injury by Modulating Myeloid-Derived Suppressor Cells and CD4+ T Cells in Mice. Stem Cell Research & Therapy, 10, Article No. 22. https://doi.org/10.1186/s13287-018-1128-2 |
| [11] | 李珊珊, 毕研贞, 王全全, 等. 不同分化阶段小鼠肝干细胞通过调节Treg和Th17细胞改善ConA诱导的小鼠急性肝损伤[C]//全国疑难及重症肝病攻关协作组(CNSLD), 吴阶平医学基金会(Wu Jieping Medical Foundation), 北京肝胆相照公益基金会(Beijing Gandan Foundation), 北京医药科学技术发展协会(BMA), 首都医科大学科技园肝病转化医学研究所(THI-CMU). 第十届全国疑难及重症肝病大会论文集. 2019: 118. |
| [12] | 韩鲁祥, 唐慧昕, 赵振峰, 等. 成体人肝源性干细胞外泌体对刀豆蛋白A诱导的小鼠急性肝损伤的作用[J]. 临床肝胆病杂志, 2022, 38(5): 1101-1105. |
| [13] | 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 酒精性肝病诊疗指南[J]. 临床肝胆病杂志, 2010, 26(3): 229-232. |
| [14] | 毕研贞, 张秋生, 樊增, 等. 人成体肝源性干细胞对酒精性脂肪肝小鼠模型的防治作用[J]. 临床肝胆病杂志, 2019, 35(3): 592-595. |
| [15] | 唐慧昕. 人肝源性干细胞对非酒精性脂肪肝的治疗作用研究[D]: [硕士学位论文]. 济宁: 济宁医学院, 2020. |
| [16] | Svegliati‐Baroni, G., De Minicis, S. and Marzioni, M. (2008) Hepatic Fibrogenesis in Response to Chronic Liver Injury: Novel Insights on the Role of Cell‐to‐Cell Interaction and Transition. Liver International, 28, 1052-1064. https://doi.org/10.1111/j.1478-3231.2008.01825.x |
| [17] | 毕研贞, 洪丰, 王全全, 等. 人成体肝干细胞预防四氯化碳诱导的小鼠肝纤维化的实验研究[C]//全国疑难及重症肝病攻关协作组(CNSLD), 吴阶平医学基金会(Wu Jieping Medical Foundation), 北京肝胆相照公益基金会(Beijing Gandan Foundation), 北京医药科学技术发展协会(BMA), 首都医科大学科技园肝病转化医学研究所(THI-CMU). 第十届全国疑难及重症肝病大会论文集. 2019: 228-229. |
| [18] | Zheng, Q., Zheng, Y., Chen, J., You, J., Zhu, Y., Liu, Y., et al. (2017) A Hepatic Stem Cell Vaccine Is Superior to an Embryonic Stem Cell Vaccine in the Prophylaxis and Treatment of Murine Hepatocarcinoma. Oncology Reports, 37, 1716-1724. https://doi.org/10.3892/or.2017.5381 |
| [19] | 刘波, 林楠, 胡鲲鹏. 肝卵圆细胞经脾脏移植治疗肝纤维化的实验研究[J]. 中国医师杂志, 2009, 11(8): 1040-1044. |
| [20] | 刘波, 林楠, 胡鲲鹏. 肝卵圆细胞与骨髓间质干细胞经脾移植治疗实验性小鼠肝纤维化的疗效比较[J]. 中国医师杂志, 2009, 11(9): 1191-1194. |
| [21] | 郑龙坤. 人肝源性干细胞对结肠癌肝转移的抑制作用及其机制研究[D]: [硕士学位论文]. 济宁: 济宁医学院, 2023. |
