NLR与女性急性冠脉综合征患者的冠脉狭窄度的相关性
The Correlation between NLR and the Degree of Coronary Artery Stenosis in Female Patients with Acute Coronary Syndrome

目的：探究中性粒细胞与淋巴细胞比值在女性急性冠脉综合征患者中与冠脉狭窄程度的相关性及对急性心肌梗死的诊断价值。方法：回顾性收集2022年1月至2024年8月于邯郸市中心医院行冠状动脉造影术的女性急性冠脉综合征患者共123例，其中UA组71例，AMI组52例，选取Gensini评分对冠脉造影结果进行评估，分为中低分组(GS < 66)，高分组(GS ≥ 66)。结果：(1) 女性UA组与AMI组在收缩压、WBC、NEUT、LDL-C、HDL-C、NLR的比较差异存在统计学意义(P < 0.05)；(2) WBC、NEUT、LDL-C、HDL-C、TG、TC、NLR均与Gensini评分呈正相关(P < 0.05)；(3) 多因素logistic回归分析显示LDL-C、HDL-C、NLR是冠脉狭窄严重程度的独立危险因素(P < 0.05)；(4) ROC曲线显示NLR诊断女性AMI截断值3.731，灵敏度61.5%，特异度78.9%，曲线下面积0.756 (95% CI: 0.669~0.843)。结论：NLR与女性ACS患者的冠脉狭窄程度呈正相关，是女性冠脉狭窄严重程度的独立危险因素，可能是区分女性UA和AMI的指标。
Objective: To explore the correlation between the neutrophil-to-lymphocyte ratio (NLR) and the degree of coronary artery stenosis in female patients with acute coronary syndrome (ACS) and its diagnostic value for acute myocardial infarction (AMI). Methods: A retrospective analysis was conducted on 123 female patients with ACS who underwent coronary angiography at Handan Central Hospital from January 2022 to August 2024, including 71 patients in the unstable angina (UA) group and 52 patients in the AMI group. The Gensini score was used to evaluate the results of coronary angiography, and the patients were divided into a low-to-moderate score group (GS < 66) and a high score group (GS ≥ 66). Results: (1) There were statistically significant differences in systolic blood pressure, white blood cell count (WBC), neutrophil count (NEUT), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and NLR between the UA group and the AMI group (P < 0.05); (2) WBC, NEUT, LDL-C, HDL-C, triglycerides (TG), total cholesterol (TC), and NLR were positively correlated with the Gensini score (P < 0.05); (3) Multivariate logistic regression analysis showed that LDL-C, HDL-C, and NLR were independent risk factors for the severity of coronary artery stenosis (P < 0.05); (4) The ROC curve indicated that the cut-off value of NLR for diagnosing AMI in females was 3.731, with a sensitivity of 61.5%, a specificity of 78.9%, and an area under the curve of 0.756 (95% CI: 0.669~0.843). Conclusion: NLR is positively correlated with the degree of coronary artery stenosis in female ACS patients and is an independent risk factor for the severity of coronary artery stenosis. It may be an indicator to distinguish between UA and AMI in females.