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Medical Diagnosis 2025
炎症相关脂肪因子在多囊卵巢综合征中的研究进展
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Abstract:
多囊卵巢综合征(PCOS)是一种影响广泛的生殖内分泌疾病，常导致女性生育能力下降及代谢健康问题。慢性炎症反应被证明参与了PCOS的发生和发展，PCOS体内炎症因子表达异常与胰岛素抵抗、高雄激素血症、肥胖等存在着密切联系。近年来，脂肪因子作为一种新兴的生物标志物和治疗靶点，在PCOS的发生发展与病理生理机制中扮演了重要角色，与PCOS患者的临床表现及代谢状态存在显著相关性，提示其可能在疾病的诊断和预后评估中具有潜在的应用价值，可能为临床干预提供新的思路。综上所述，本文旨在综述炎症相关脂肪因子在PCOS病理生理、临床表现、代谢紊乱中的最新研究进展。
Polycystic Ovary Syndrome (PCOS) is a widespread reproductive endocrine disorder that often leads to decreased fertility and metabolic health issues in women. Chronic inflammatory responses have been proven to be involved in the occurrence and development of PCOS, with abnormal expression of inflammatory factors within the body of PCOS patients being closely related to insulin resistance, hyperandrogenism, obesity, and more. In recent years, adipokines, as emerging biomarkers and therapeutic targets, have played a significant role in the development and pathophysiological mechanisms of PCOS. They exhibit significant correlations with the clinical manifestations and metabolic status of PCOS patients, suggesting their potential application value in disease diagnosis and prognostic evaluation, and possibly offering new perspectives for clinical intervention. In summary, this article aims to review the latest research progress on inflammation-related adipokines in the pathophysiology, clinical manifestations, and metabolic disorders of PCOS.
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