Contribution of Endoscopic Retrograde Cholangiopancreatography (ERCP) in the Treatment of Bilio-Pancreatic Pathologies: Experience from the Agadir Region
Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is a key technique for managing biliary and pancreatic diseases, combining endoscopy and radiology. Initially a diagnostic tool, ERCP is now primarily used for therapeutic interventions, supported by advancements in MRI and endoscopic ultrasound. Despite its effectiveness, ERCP carries risks that depend on patient conditions and procedural complexity. This study evaluates ERCP’s role in treating biliary diseases and associated complications in a regional setting. Materials and Methods: A retrospective study was conducted over four years (2020-2023) at Agadir Regional Hospital and Oued Eddahab Agadir Military Hospital. The study included all patients undergoing ERCP for biliary or pancreatic pathology. Data were collected from medical records, and statistical analysis was performed using Jamovi software. Results: A total of 77 patients were included, with a mean age of 62.1 years. The majority were women (sex ratio F/M = 1.3). The most common indication for ERCP was biliary lithiasis (75.3%), followed by tumor pathology (23.3%). Among tumor cases, pancreatic head adenocarcinoma (72.2%) was the most frequent, followed by cholangiocarcinoma. Management included metal (55%) and plastic (22%) stent placements. Biliary lithiasis was complicated by pancreatitis and/or cholangitis in 15.5% of cases. The bile duct was successfully catheterized in 93% of cases, with clearance achieved in 86.2% of patients. Complications were reported in 5% of cases, including mild pancreatitis, digestive perforation, and hemorrhage. One patient died due to pulmonary embolism. Conclusion: ERCP remains a crucial procedure for managing biliary and pancreatic diseases, particularly for lithiasis and tumor-related strictures. It allowed effective biliary drainage in tumor cases (77.8%) and successful bile duct clearance in 92.5% of lithiasis cases, with a low complication rate (5%).
References
[1]
Fumex, F. (2016) Risks and Complications of ERCP. Hopital Privé Jean Mermoz, Lyon. FMC POST’U.
[2]
McCune, W.S., Shorb, P.E. and Moscovitz, H. (1968) Endoscopic Cannulation of the Ampulla of Vater: A Preliminary Report. Annals of Sur-gery, 167, 752-756. https://doi.org/10.1097/00000658-196805000-00013
[3]
Shim, C., Kim, J., Lee, T. and Cheon, Y. (2016) Is Endoscopic Papillary Large Balloon Dilation Safe for Treating Large CBD Stones? Saudi Journal of Gastroenterolo-gy, 22, 251-259. https://doi.org/10.4103/1319-3767.187599
[4]
Vitte, R. and Morfoisse, J. (2007) Evaluation of En-doscopic Retrograde Cholangiopancreatography Procedures Performed in General Hospitals in France. Gastroentérologie Clinique et Biologique, 31, 740-749. https://doi.org/10.1016/s0399-8320(07)91936-3
[5]
Hasni Alaoui, Y. (2011) Hydatid Cyst of Liver Segment 1.
[6]
Dumonceau, J., Andriulli, A., Elmunzer, B., Mariani, A., Meister, T., Deviere, J., et al. (2014) Prophylaxis of Post-ERCP Pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline—Updated June 2014. Endoscopy, 46, 799-815. https://doi.org/10.1055/s-0034-1377875
[7]
Testoni, P., Mariani, A., Aabakken, L., Arvanitakis, M., Bories, E., Costamagna, G., et al. (2016) Papillary Cannulation and Sphincterotomy Techniques at ERCP: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy, 48, 657-683. https://doi.org/10.1055/s-0042-108641
[8]
Bories, E., Pesenti, C., Caillol, F., Lopes, C. and Giovannini, M. (2007) Transgastric Endoscopic Ultrasonography-Guided Biliary Drainage: Results of a Pilot Study. Endoscopy, 39, 287-291. https://doi.org/10.1055/s-2007-966212
[9]
Andriulli, A., Loperfido, S., Napolitano, G., Niro, G., Valvano, M.R., Spirito, F., et al. (2007) Incidence Rates of Post-ERCP Complications: A Systematic Survey of Prospective Studies. The American Journal of Gastroenterology, 102, 1781-1788. https://doi.org/10.1111/j.1572-0241.2007.01279.x
[10]
Gupta, N., Poreddy, V. and Al-Kawas, F. (2008) Endoscopy in the Management of Choledocholithiasis. Current Gastroenterology Reports, 10, 169-176. https://doi.org/10.1007/s11894-008-0039-2
[11]
Boulay, B.R. and Birg, A. (2016) Malignant Biliary Obstruc-tion: From Palliation to Treatment. World Journal of Gastrointestinal Oncology, 8, 498-508. https://doi.org/10.4251/wjgo.v8.i6.498
[12]
Singh, A., Mann, H.S., Thukral, C.L. and Singh, N.R. (2014) Diagnostic Accu-racy of MRCP as Compared to Ultrasound/CT in Patients with Obstructive Jaundice. Journal of Clinical and Diagnostic Re-search, 8, 103-107. https://doi.org/10.7860/jcdr/2014/8149.4120
[13]
Azza, D. (2017) Endoscopic Biliary Drainage of Bilio-Pancreatic Tumors: Results and Associated Factors. Doctoral Thesis, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, No. 127/17.
[14]
Drouet d’Aubigny, A. (2014) Prognostic Study of Patients with Neoplastic Biliary Obstruction Treated by Drainage at the CHU of Brest between 2014 and 2018. Life Sciences.
[15]
Rim, B. (2018) Interest of Palliative Treatment with Stent in Biliopancreatic Cancers. Doctoral Thesis, Faculty of Medicine and Pharmacy, Moham-med V University of Rabat, No. 346/18.
[16]
Errahmani, I. (2020) Management of Malignant Biliary Strictures: Experience of a Day Hospital. Doctoral Thesis, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, No. 352/20.
[17]
Prat, F., De Baere, T. and Pelletier, G. (2004) Traitement instrumental non chirurgical des pathologies biliaires intra- et extrahépatiques. EMC-Hépatologie, 1, 15-34. https://doi.org/10.1016/j.emchep.2003.10.001
[18]
De Palma, G.D., Galloro, G., Siciliano, S., Iovino, P. and Catanzano, C. (2001) Unilateral versus Bilateral Endoscopic Hepatic Duct Drainage in Patients with Malignant Hilar Biliary Obstruction: Results of a Prospective, Randomized, and Controlled Study. Gastrointestinal Endoscopy, 53, 547-553. https://doi.org/10.1067/mge.2001.113381
[19]
Brugge, W.R. (2005) Endo-scopic Techniques to Diagnose and Manage Biliary Tumors. Journal of Clinical Oncology, 23, 4561-4565. https://doi.org/10.1200/jco.2005.19.729
[20]
Vienne, A. (2014) Biliary Stricture: Diagnosis and Treatment. Hepa-to-Gastroenterology, 21, 698-709.
[21]
Maillard, M., Novellas, S., Baudin, G., Evesque, L., Bellmann, L., Gugenheim, J., et al. (2012) Placement of Metallic Biliary Endoprostheses in Complex Hilar Tumours. Diagnostic and Interventional Imaging, 93, 767-774. https://doi.org/10.1016/j.diii.2012.05.014
[22]
Sangchan, A., Kongkasame, W., Pugkhem, A., Jenwitheesuk, K. and Mairiang, P. (2012) Efficacy of Metal and Plastic Stents in Unresectable Complex Hilar Cholangiocarcinoma: A Random-ized Controlled Trial. Gastrointestinal Endoscopy, 76, 93-99. https://doi.org/10.1016/j.gie.2012.02.048
[23]
Canard, J.M., Létard, J.-C. and Palazzo, L. (2006) Digestive Endoscopy. 467-596.
[24]
Blamey, S.L., Fearon, K.C.H., Gilmour, W.H., Osborne, D.H. and Carter, D.C. (1983) Prediction of Risk in Biliary Surgery. Journal of British Surgery, 70, 535-538. https://doi.org/10.1002/bjs.1800700910
[25]
Seddik, H. (2021) Interest of ERCP in Acute Biliary Pancreatitis. Faculty of Medicine and Pharmacy, Mohammed V University of Rabat.
[26]
Benkirane, A. (2021) Contribution of Endoscopic Retro-grade Cholangiography in the Treatment of Large Choledochal Stones: Success Rate and Associated Factors. Faculty of Medi-cine and Pharmacy, Mohammed V University of Rabat.
[27]
Moussadek, M. (2021) Preoperative Endoscopic Treatment for the Management of Concomitant Gallstones and Common Bile Duct Stones. La Tunisie Medicale, 99, 233-237.
[28]
Van Erpecum, K.J. (2011) Pathogenesis of Cholesterol and Pigment Gallstones: An Update. Clinics and Research in Hepatology and Gastroenterology, 35, 281-287. https://doi.org/10.1016/j.clinre.2011.01.009
[29]
Buffet, C., Jacquemin, E. and Er-linger, S. (2008) Pathophysiology, Epidemiology, and Natural History of Gallstone Disease. Hepatology, 3, 114.
[30]
Mori-no, M., Baracchi, F., Miglietta, C., Furlan, N., Ragona, R. and Garbarini, A. (2006) Preoperative Endoscopic Sphincterotomy versus Laparoendoscopic Rendezvous in Patients with Gallbladder and Bile Duct Stones. Annals of Surgery, 244, 889-896. https://doi.org/10.1097/01.sla.0000246913.74870.fc
[31]
Hamy, A., Hennekinne, S., Pessaux, P., Lada, P., Randriamananjo, S., Lermite, E., et al. (2003) Endoscopic Sphincterotomy Prior to Laparoscopic Cholecystectomy for the Treatment of Cholelithiasis. Surgical Endoscopy, 17, 872-875. https://doi.org/10.1007/s00464-002-9039-8
[32]
Tan, C., Ocampo, O., Ong, R. and Tan, K.S. (2017) Comparison of One Stage Laparoscopic Cholecystectomy Combined with In-tra-Operative Endoscopic Sphincterotomy versus Two-Stage Pre-Operative Endoscopic Sphincterotomy Followed by Lapa-roscopic Cholecystectomy for the Management of Pre-Operatively Diagnosed Patients with Common Bile Duct Stones: A Me-ta-Analysis. Surgical Endoscopy, 32, 770-778. https://doi.org/10.1007/s00464-017-5739-y
[33]
Gao, Y., Chen, J., Qin, Q., Chen, H., Wang, W., Zhao, J., et al. (2017) Efficacy and Safety of Laparoscopic Bile Duct Exploration versus Endoscopic Sphincterotomy for Concomitant Gallstones and Common Bile Duct Stones: A Meta-Analysis of Randomized Controlled Trials. Medicine, 96, e7925. https://doi.org/10.1097/md.0000000000007925
[34]
ElGeidie, A.A., ElEbidy, G.K. and Naeem, Y.M. (2010) Preoperative versus Intraoperative Endoscopic Sphincterotomy for Management of Common Bile Duct Stones. Surgical Endoscopy, 25, 1230-1237. https://doi.org/10.1007/s00464-010-1348-8