Osteoarthritis (OA), a common chronic joint disease, significantly affects the quality of life of patients. This article comprehensively reviews the treatment progress of osteoarthritis, covering multiple aspects such as non-pharmacological treatment, pharmacological treatment, surgical treatment, and emerging treatment methods, aiming to provide references for clinical treatment and promote further development in the field of osteoarthritis treatment.
References
[1]
Yunus, M.H.M., Nordin, A. and Kamal, H. (2020) Pathophysiological Perspective of Osteoarthritis. Medicina, 56, Article 614. https://doi.org/10.3390/medicina56110614
[2]
Szala, D., Kopańska, M., Trojniak, J., Jabłoński, J., Hanf-Osetek, D., Snela, S., et al. (2024) The Role of Micrornas in the Pathophysiology of Osteoarthritis. InternationalJournalofMolecularSciences, 25, Article 6352. https://doi.org/10.3390/ijms25126352
[3]
Hodgkinson, T., Kelly, D.C., Curtin, C.M. and O’Brien, F.J. (2021) Mechanosignalling in Cartilage: An Emerging Target for the Treatment of Osteoarthritis. NatureReviewsRheumatology, 18, 67-84. https://doi.org/10.1038/s41584-021-00724-w
[4]
Zhong, D., Chen, X.I., Zhang, W. and Luo, Z.P. (2018) Excessive Tensile Strain Induced the Change in Chondrocyte Phenotype. Acta of Bioengineering and Biomechanics, 20, 3-10.
[5]
Huang, J., Ballou, L.R. and Hasty, K.A. (2007) Cyclic Equibiaxial Tensile Strain Induces Both Anabolic and Catabolic Responses in Articular Chondrocytes. Gene, 404, 101-109. https://doi.org/10.1016/j.gene.2007.09.007
[6]
Gilat, R., Haunschild, E.D., Knapik, D.M., Evuarherhe, A., Parvaresh, K.C. and Cole, B.J. (2020) Hyaluronic Acid and Platelet-Rich Plasma for the Management of Knee Osteoarthritis. International Orthopaedics, 45, 345-354. https://doi.org/10.1007/s00264-020-04801-9
[7]
Lim, Y.Z., Wong, J., Hussain, S.M., Estee, M.M., Zolio, L., Page, M.J., et al. (2022) Recommendations for Weight Management in Osteoarthritis: A Systematic Review of Clinical Practice Guidelines. Osteoarthritis and Cartilage Open, 4, Article ID: 100298. https://doi.org/10.1016/j.ocarto.2022.100298
[8]
Zelman, D.C., Dukes, E., Brandenburg, N., Bostrom, A. and Gore, M. (2005) Identification of Cut-Points for Mild, Moderate and Severe Pain Due to Diabetic Peripheral Neuropathy. Pain, 115, 29-36. https://doi.org/10.1016/j.pain.2005.01.028
[9]
Kapstad, H., Hanestad, B.R., Langeland, N., Rustøen, T. and Stavem, K. (2008) Cutpoints for Mild, Moderate and Severe Pain in Patients with Osteoarthritis of the Hip or Knee Ready for Joint Replacement Surgery. BMCMusculoskeletalDisorders, 9, Article No. 55. https://doi.org/10.1186/1471-2474-9-55
[10]
Nahler, G. (2009) Anatomical Therapeutic Chemical Classification System (ATC). In: Nahler, G., Brunier, D., Mollet, A., Nahler, M. and Szucs, T.D., Eds., DictionaryofPharmaceuticalMedicine, Springer, 8. https://doi.org/10.1007/978-3-211-89836-9_64
[11]
Yoo, C., Lee, S., Lee, C., Kim, Y.W., Han, S.K. and Shim, Y. (2001) Effect of Acetylsalicylic Acid on Endogenous IκB Kinase Activity in Lung Epithelial Cells. AmericanJournalofPhysiology-LungCellularandMolecularPhysiology, 280, L3-L9. https://doi.org/10.1152/ajplung.2001.280.1.l3
[12]
Amann, R. and Peskar, B.A. (2002) Anti-inflammatory Effects of Aspirin and Sodium Salicylate. EuropeanJournalofPharmacology, 447, 1-9. https://doi.org/10.1016/s0014-2999(02)01828-9
[13]
Puljak, L., Marin, A., Vrdoljak, D., Markotic, F., Utrobicic, A. and Tugwell, P. (2017) Celecoxib for Osteoarthritis. Cochrane Database of Systematic Reviews, 5, CD009865. https://doi.org/10.1002/14651858.cd009865.pub2
[14]
da Costa, B.R., et al. (2021) Effectiveness and Safety of Non-Steroidal Anti-Inflammatory Drugs and Opioid Treatment for Knee and Hip Osteoarthritis: Network Meta-Analysis. BMJ, 375, n2321.
[15]
Samuels, J., Pillinger, M.H., Jevsevar, D., Felson, D. and Simon, L.S. (2021) Critical Appraisal of Intra-Articular Glucocorticoid Injections for Symptomatic Osteoarthritis of the Knee. OsteoarthritisandCartilage, 29, 8-16. https://doi.org/10.1016/j.joca.2020.09.001
[16]
Bodick, N., Lufkin, J., Willwerth, C., Kumar, A., Bolognese, J., Schoonmaker, C., et al. (2015) An Intra-Articular, Extended-Release Formulation of Triamcinolone Acetonide Prolongs and Amplifies Analgesic Effect in Patients with Osteoarthritis of the Knee. JournalofBoneandJointSurgery, 97, 877-888. https://doi.org/10.2106/jbjs.n.00918
[17]
Russell, S.J., Sala, R., Conaghan, P.G., Habib, G., Vo, Q., Manning, R., et al. (2018) Triamcinolone Acetonide Extended-Release in Patients with Osteoarthritis and Type 2 Diabetes: A Randomized, Phase 2 Study. Rheumatology, 57, 2235-2241. https://doi.org/10.1093/rheumatology/key265
[18]
Fransen, M., Agaliotis, M., Nairn, L., Votrubec, M., Bridgett, L., Su, S., et al. (2015) Glucosamine and Chondroitin for Knee Osteoarthritis: A Double-Blind Randomised Placebo-Controlled Clinical Trial Evaluating Single and Combination Regimens. AnnalsoftheRheumaticDiseases, 74, 851-858. https://doi.org/10.1136/annrheumdis-2013-203954
[19]
Iovu, M., Dumais, G. and du Souich, P. (2008) Anti-Inflammatory Activity of Chondroitin Sulfate. OsteoarthritisandCartilage, 16, S14-S18. https://doi.org/10.1016/j.joca.2008.06.008
[20]
David-Raoudi, M., Mendichi, R. and Pujol, J.P. (2009) For Intra-Articular Delivery of Chondroitin Sulfate. Glycobiology, 19, 813-815. https://doi.org/10.1093/glycob/cwp069
[21]
Moots, R.J., Xavier, R.M., Mok, C.C., Rahman, M.U., Tsai, W., Al-Maini, M.H., et al. (2017) The Impact of Anti-Drug Antibodies on Drug Concentrations and Clinical Outcomes in Rheumatoid Arthritis Patients Treated with Adalimumab, Etanercept, or Infliximab: Results from a Multinational, Real-World Clinical Practice, Non-Interventional Study. PLOSONE, 12, e0175207. https://doi.org/10.1371/journal.pone.0175207
[22]
Wang, L., Zhang, X., Zhang, X., Guo, D., Duan, Y., Wang, Z., et al. (2020) Evaluation of the Therapeutic Effect of Traditional Chinese Medicine on Osteoarthritis: A Systematic Review and Meta-Analysis. PainResearchandManagement, 2020, Article ID: 5712187. https://doi.org/10.1155/2020/5712187
[23]
O’Connor, D., Johnston, R.V., Brignardello-Petersen, R., Poolman, R.W., Cyril, S., Vandvik, P.O., et al. (2022) Arthroscopic Surgery for Degenerative Knee Disease (Osteoarthritis Including Degenerative Meniscal Tears). CochraneDatabaseofSystematicReviews, 3, CD014328. https://doi.org/10.1002/14651858.cd014328
[24]
Amendola, A. and Bonasia, D.E. (2009) Results of High Tibial Osteotomy: Review of the Literature. InternationalOrthopaedics, 34, 155-160. https://doi.org/10.1007/s00264-009-0889-8
[25]
Park, H.J., Suh, D.H., Hong, H., Nha, K., Kim, H., Kang, K., et al. (2024) Biomechanical Evaluation of a Newly Designed Locking Plate for Opening Wedge High Tibial Osteotomy: Stress Distribution and Stability in the Presence of Lateral Hinge Fracture. JournalofOrthopaedicSurgeryandResearch, 19, Article No. 800. https://doi.org/10.1186/s13018-024-05283-w
[26]
Varnum, C., Pedersen, A.B., Rolfson, O., Rogmark, C., Furnes, O., Hallan, G., et al. (2019) Impact of Hip Arthroplasty Registers on Orthopaedic Practice and Perspectives for the Future. EFORTOpenReviews, 4, 368-376. https://doi.org/10.1302/2058-5241.4.180091
[27]
Leibovitch, L., Machinski, E., Fernandes, A., Park, J.Y., Souza, G., Sayudo, I.F., et al. (2024) Direct Anterior vs Other Surgical Approaches in Patients with Lumbar Stiffness Undergoing Total Hip Arthroplasty: A Systematic Review and Meta-Analysis. ArchivesofOrthopaedicandTraumaSurgery, 145, Article No. 48. https://doi.org/10.1007/s00402-024-05682-y
[28]
Arutyunyan, I., Elchaninov, A., Makarov, A. and Fatkhudinov, T. (2016) Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy. StemCellsInternational, 2016, Article ID: 6901286. https://doi.org/10.1155/2016/6901286
[29]
Wang, A., Feng, Y., Jia, H., Zhao, M. and Yu, H. (2019) Application of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee: A Concise Review. WorldJournalofStemCells, 11, 222-235. https://doi.org/10.4252/wjsc.v11.i4.222
[30]
Rosenberg, S.A., Packard, B.S., Aebersold, P.M., Solomon, D., Topalian, S.L., Toy, S.T., et al. (1988) Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma. NewEnglandJournalofMedicine, 319, 1676-1680. https://doi.org/10.1056/nejm198812223192527
[31]
Rosenberg, S.A., Aebersold, P., Cornetta, K., Kasid, A., Morgan, R.A., Moen, R., et al. (1990) Gene Transfer into Humans—Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction. NewEnglandJournalofMedicine, 323, 570-578. https://doi.org/10.1056/nejm199008303230904
[32]
Blaese, R.M., Culver, K.W., Miller, A.D., Carter, C.S., Fleisher, T., Clerici, M., et al. (1995) T Lymphocyte-Directed Gene Therapy for ADA-SCID: Initial Trial Results after 4 Years. Science, 270, 475-480. https://doi.org/10.1126/science.270.5235.475
[33]
Zhu, Y., Yuan, M., Meng, H.Y., Wang, A.Y., Guo, Q.Y., Wang, Y., et al. (2013) Basic Science and Clinical Application of Platelet-Rich Plasma for Cartilage Defects and Osteoarthritis: A Review. OsteoarthritisandCartilage, 21, 1627-1637. https://doi.org/10.1016/j.joca.2013.07.017
[34]
Sheean, A.J., Anz, A.W. and Bradley, J.P. (2021) Platelet-rich Plasma: Fundamentals and Clinical Applications. Arthroscopy: TheJournalofArthroscopic&RelatedSurgery, 37, 2732-2734. https://doi.org/10.1016/j.arthro.2021.07.003
[35]
Uchiyama, R., Toyoda, E., Maehara, M., Wasai, S., Omura, H., Watanabe, M., et al. (2021) Effect of Platelet-Rich Plasma on M1/M2 Macrophage Polarization. InternationalJournalofMolecularSciences, 22, Article 2336. https://doi.org/10.3390/ijms22052336
[36]
Szwedowski, D., Szczepanek, J., Paczesny, Ł., Zabrzyński, J., Gagat, M., Mobasheri, A., et al. (2021) The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis. InternationalJournalofMolecularSciences, 22, Article 5492. https://doi.org/10.3390/ijms22115492