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sFlt-1/PlGF预测子痫前期的研究进展
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Abstract:
随着我国“二孩”、“三孩”生育率明显提升，高龄产妇、妊娠合并症以及并发症的高危人群随之增长。作为妊娠常见的并发症之一，子痫前期是妊娠期特有的全身性多系统综合征，严重威胁母婴健康。血清可溶性血管内皮生长因子受体-1 (sFlt-1)和胎盘生长因子(PlGF)在子痫前期的发生发展中起重要作用。本文综述了近年来关于sFlt-1/PlGF预测子痫前期的研究进展，旨在为早期诊断和治疗提供理论支持。本文收集了多篇相关文献，从子痫前期的病理机制、sFlt-1和PlGF的概述、sFlt-1和PlGF与子痫前期关系、预测价值等方面进行了归纳和分析。结果发现sFlt-1/PlGF可预测子痫前期的发病，为早期预防疑似子痫前期高危孕妇提供依据，以38为截断值可预测子痫前期的严重程度，多指标联合预测提高预测的准确性，预测模型是当前研究热点，有望成为预测标准。
With the significant increase in the fertility rates of “second-child” and “third-child” policies in China, the number of high-risk populations, including advanced maternal age, pregnancy complications, and comorbidities, has risen accordingly. As one of the common complications of pregnancy, preeclampsia is a pregnancy-specific systemic multisystem syndrome that poses a serious threat to maternal and fetal health. Soluble Fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) play crucial roles in the development and progression of preeclampsia. This article reviews recent research progress on the use of sFlt-1/PlGF ratio for predicting preeclampsia, aiming to provide theoretical support for early diagnosis and treatment. By collecting multiple relevant studies, this paper summarizes and analyzes the pathological mechanisms of preeclampsia, the overview of sFlt-1 and PlGF, their relationship with preeclampsia, and their predictive value. The findings indicate that the sFlt-1/PlGF ratio can predict the onset of preeclampsia, providing a basis for early prevention in high-risk pregnant women suspected of preeclampsia. A cutoff value of 38 can predict the severity of preeclampsia, while combining multiple indicators improves predictive accuracy. Predictive models are currently a research hotspot and are expected to become a standard for prediction.
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