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MMP-9在中枢神经系统感染性疾病诊断中的研究进展
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Abstract:
中枢神经系统感染性疾病是病原微生物侵犯中枢神经系统(central nervous system, CNS)的实质、背膜及血管等引起的急性或慢性炎症(或非炎症性)疾病，这些病原微生物包括病毒、细菌、真菌、螺旋体、寄生虫、朊蛋白等。多种物质参与中枢神经系统感染性疾病的发生及发展。基质金属蛋白酶(matrix metalloproteinases, MMPs)是一个包括20多种蛋白在内的大家族。它参与胚胎发育、前体细胞或干细胞动员、创面重塑和愈合等生理反应，以及炎症、肿瘤进展和转移、血管内皮细胞损伤等病理反应。其中基质金属蛋白酶-9 (matrix metalloproteinase-9, MMP-9)在中枢神经系统疾病中发挥着重要的作用，无论是中枢神经系统感染性疾病还是肿瘤，目前的研究线索指向MMP-9与血脑屏障(blood brain barrier, BBB)的破坏相关。本文将就其研究现状进行综述和讨论。
Infectious diseases of the central nervous system are acute or chronic inflammatory (or non- inflammatory) diseases caused by pathogenic microorganisms invading the substance, dorsal membrane and blood vessels of the central nervous system (CNS). These pathogenic microorganisms include viruses, bacteria, fungi, spirochetes, parasites, prions, etc. Many substances are involved in the occurrence and development of central nervous system infectious diseases. Matrix metalloproteinases (MMPs) are a large family that includes over 20 proteins. It participates in physiological reactions such as embryonic development, mobilization of precursor cells or stem cells, wound remodeling and healing, as well as pathological reactions such as inflammation, tumor progression and metastasis, and damage to vascular endothelial cells. Matrix metalloproteinase-9 (MMP-9) plays an important role in central nervous system diseases. Whether it is central nervous system infectious diseases or tumors, the current research clues point to the relationship between MMP-9 and the destruction of blood brain barrier (BBB). This article will review and discuss the current research status.
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