The Hyaluron Pen, a needle-free device designed to deliver hyaluronic acid into the dermis, has gained significant popularity in non-invasive aesthetic procedures. However, its misuse by individuals with limited knowledge of injection techniques raises serious safety concerns, with some sources even contraindicating its use due to the risks associated with improper handling. Despite its appeal, the lack of standardized practices poses significant challenges in ensuring safety, efficacy, and optimal patient outcomes. This review examines the current landscape of Hyaluron Pen usage, focusing on variations in practitioner training, device protocols, and procedural techniques. It highlights potential risks, including adverse events such as overfilling, migration, and infection, often resulting from inadequate training, improper usage, and insufficient sterilization practices. Clinical data is reviewed to identify best practices for patient selection, dosage regulation, and post-procedure care. Additionally, we propose a framework for establishing evidence-based guidelines, emphasizing the need for regulatory oversight and uniform training standards in aesthetic medicine. By advocating for standardized protocols, this work aims to enhance the safety, credibility, and effectiveness of Hyaluron Pen applications, fostering trust among both practitioners and patients.
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