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动脉硬化在慢性肾脏疾病中的研究进展
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Abstract:
动脉硬化是导致慢性肾脏疾病(Chronic Kidney Disease, CKD)进展的重要因素之一。当肾动脉发生硬化时，会导致肾脏供血不足，进而影响肾脏的正常功能。动脉硬化还可能促进肾脏内微小血管的病变，进一步加速肾脏功能的损害。慢性肾脏疾病本身也可能导致或加重动脉硬化。当肾脏功能受损时，体内异常代谢物质的堆积和水电解质平衡的紊乱会引发心血管问题，包括高血压、高脂血症等，这些危险因素都会促进动脉硬化的发生。动脉硬化和慢性肾脏疾病之间存在着密切的联系和相互影响。本文旨在明确慢性肾疾病以及终末期肾疾病相关的心血管疾病治疗靶点，为临床降低慢性肾疾病相关心血管疾病提供观点。
Arteriosclerosis is one of the important factors leading to the progression of chronic kidney disease (CKD). When the renal arteries are hardened, the blood supply to the kidneys is insufficient, which in turn affects the normal function of the kidneys. Arteriosclerosis may also promote the lesion of tiny blood vessels in the kidneys, further accelerating the damage to kidney function. Chronic kidney disease itself can also cause or worsen arteriosclerosis. When kidney function is impaired, the accumulation of abnormal metabolites in the body and the disturbance of water and electrolyte balance can lead to cardiovascular problems, including hypertension, hyperlipidemia, etc., and these risk factors will promote the occurrence of arteriosclerosis. There is a strong link and interaction between arteriosclerosis and chronic kidney disease. The purpose of this article is to clarify the therapeutic targets of chronic kidney disease and end-stage renal disease-related cardiovascular diseases, and to provide perspectives for clinical reduction of chronic kidney disease-related cardiovascular diseases.
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