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血糖相关指标与心肌梗死后不良后果关系的研究进展
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Abstract:
心肌梗死(myocardial infarction, MI)是一种威胁人们健康的严重疾病，在MI的治疗方面现已取得重大进展，但仍有部分患者存在预后不良的情况。既往多项研究表明血糖与心肌梗死及心肌梗死后不良后果相关，近来血糖相关指标如糖化血红蛋白(HbA1c)、应激性高血糖比值(SHR)、血红蛋白糖化指数(HGI)、甘油三酯葡萄糖指数(TyG)、甘油三酯葡萄糖–体质指数(TyG-BMI)也被证明与其相关。现就血糖相关指标与心肌梗死后不良后果的关系作出综述，以期预测心肌梗死患者不良后果发生率，尽早识别高危患者，制定预防措施，改善患者预后。
Myocardial infarction (MI) is a serious disease that threatens people’s health. Significant progress has been made in the treatment of MI, but there are still some patients with poor prognosis. Previous studies have shown that blood glucose is associated with myocardial infarction and its adverse consequences. Recently, blood glucose related indicators such as glycated hemoglobin (HbA1c), stress-induced hyperglycemia ratio (SHR), hemoglobin glycation index (HGI), triglyceride glucose index (TyG), and triglyceride glucose body mass index (TyG-BMI) have also been shown to be related. This article provides a review on the relationship between blood glucose related indicators and adverse outcomes after myocardial infarction, in order to predict the incidence of adverse outcomes in myocardial infarction patients, identify high-risk patients as early as possible, develop preventive measures, and improve patient prognosis.
| [1] | 北京高血压防治协会, 北京糖尿病防治协会, 北京慢性病防治与健康教育研究会, 等. 基层心血管病综合管理实践指南2020 [J]. 中国医学前沿杂志(电子版), 2020, 12(8): 1-73. |
| [2] | Thygesen, K., Alpert, J.S., Jaffe, A.S., Chaitman, B.R., Bax, J.J., Morrow, D.A., et al. (2018) Fourth Universal Definition of Myocardial Infarction (2018). Journal of the American College of Cardiology, 72, 2231-2264. https://doi.org/10.1016/j.jacc.2018.08.1038 |
| [3] | 吴茂红, 吕玲. 糖耐量异常对冠心病患者氧化应激和血管内皮功能、心率变异性的影响及阿卡波糖的干预作用[J]. 中国动脉硬化杂志, 2014, 22(3): 287-292. |
| [4] | Xue, L., Yuan, X., Zhang, S. and Zhao, X. (2021) Investigating the Effects of Dapagliflozin on Cardiac Function, Inflammatory Response, and Cardiovascular Outcome in Patients with STEMI Complicated with T2DM after PCI. Evidence-Based Complementary and Alternative Medicine, 2021, Article ID: 9388562. https://doi.org/10.1155/2021/9388562 |
| [5] | Dixit, S., Bassi-Dibai, D., Dibai-Filho, A.V., Mendes, R.G., Alqahtani, A.S., Alshehri, M.M., et al. (2024) Effect of Glycated Haemoglobin (HBA1c) on Cardiorespiratory Fitness (CRF) in a Population with Type 2 Diabetes Mellitus (T2DM): A Cross-Sectional Study. Medicina, 60, Article 1823. https://doi.org/10.3390/medicina60111823 |
| [6] | 杨杰, 唐熠达. 2023年欧洲心脏病学会糖尿病患者心血管疾病管理指南解读[J]. 中华心血管病杂志, 2023, 51(12): 1273-1277. |
| [7] | 郭玉凡, 王泽荣, 路超, 等. 糖化血红蛋白水平对急性ST段抬高型心肌梗死患者介入治疗远期预后的影响[J]. 中国循环杂志, 2021, 36(8): 762-768. |
| [8] | 郝媛媛, 马锋, 李涛等. 糖化血红蛋白水平对行PCI的非ST段抬高型心肌梗死患者远期预后的影响[J]. 中国循证心血管医学杂志, 2019, 11(10): 1174-1178, 1187. |
| [9] | Dykun, I., Bayturan, O., Carlo, J., Nissen, S.E., Kapadia, S.R., Tuzcu, E.M., et al. (2022) HbA1c, Coronary Atheroma Progression and Cardiovascular Outcomes. American Journal of Preventive Cardiology, 9, Article ID: 100317. https://doi.org/10.1016/j.ajpc.2022.100317 |
| [10] | Cheung, N.W., Wong, K.Y.C., Kovoor, P. and McLean, M. (2019) Stress Hyperglycemia: A Prospective Study Examining the Relationship between Glucose, Cortisol and Diabetes in Myocardial Infarction. Journal of Diabetes and Its Complications, 33, 329-334. https://doi.org/10.1016/j.jdiacomp.2018.12.015 |
| [11] | Koracevic, G., Vasiljevic, S., Velickovic-Radovanovic, R., Sakac, D., Obradovic, S., Damjanovic, M., et al. (2014) Stress Hyperglycemia in Acute Myocardial Infarction. Vojnosanitetski Pregled, 71, 858-869. https://doi.org/10.2298/vsp121103017k |
| [12] | Swieszkowski, S.P., Costa, D., Aladio, J.M., Matsudo, M., Pérez de la Hoz, A., Castro, M., et al. (2022) Neurohumoral Response and Stress Hyperglycemia in Myocardial Infarction. Journal of Diabetes and Its Complications, 36, Article ID: 108339. https://doi.org/10.1016/j.jdiacomp.2022.108339 |
| [13] | Roberts, G.W., Quinn, S.J., Valentine, N., Alhawassi, T., O'Dea, H., Stranks, S.N., et al. (2015) Relative Hyperglycemia, a Marker of Critical Illness: Introducing the Stress Hyperglycemia Ratio. The Journal of Clinical Endocrinology & Metabolism, 100, 4490-4497. https://doi.org/10.1210/jc.2015-2660 |
| [14] | 董征, 杨青苗, 郭彩霞. 应激性高血糖比值对急性心肌梗死患者院内不良预后的影响[J]. 首都医科大学学报, 2024, 45(3): 494-500. |
| [15] | Schmitz, T., Freuer, D., Harmel, E., Heier, M., Peters, A., Linseisen, J., et al. (2022) Prognostic Value of Stress Hyperglycemia Ratio on Short-and Long-Term Mortality after Acute Myocardial Infarction. Acta Diabetologica, 59, 1019-1029. https://doi.org/10.1007/s00592-022-01893-0 |
| [16] | Karakasis, P., Stalikas, N., Patoulias, D., Pamporis, K., Karagiannidis, E., Sagris, M., et al. (2024) Prognostic Value of Stress Hyperglycemia Ratio in Patients with Acute Myocardial Infarction: A Systematic Review with Bayesian and Frequentist Meta-Analysis. Trends in Cardiovascular Medicine, 34, 453-465. https://doi.org/10.1016/j.tcm.2023.11.006 |
| [17] | Hempe, J.M., Gomez, R., McCarter, R.J. and Chalew, S.A. (2002) High and Low Hemoglobin Glycation Phenotypes in Type 1 Diabetes: A Challenge for Interpretation of Glycemic Control. Journal of Diabetes and Its Complications, 16, 313-320. https://doi.org/10.1016/s1056-8727(01)00227-6 |
| [18] | Soros, A.A., Chalew, S.A., McCarter, R.J., Shepard, R. and Hempe, J.M. (2010) Hemoglobin Glycation Index: A Robust Measure of Hemoglobin A1c Bias in Pediatric Type 1 Diabetes Patients. Pediatric Diabetes, 11, 455-461. https://doi.org/10.1111/j.1399-5448.2009.00630.x |
| [19] | Wang, Y., Liu, H., Hu, X., Wang, A., Wang, A., Kang, S., et al. (2023) Association between Hemoglobin Glycation Index and 5-Year Major Adverse Cardiovascular Events: The REACTION Cohort Study. Chinese Medical Journal, 136, 2468-2475. https://doi.org/10.1097/cm9.0000000000002717 |
| [20] | Lin, Z., He, J., Yuan, S., Song, C., Bian, X., Yang, M., et al. (2024) Hemoglobin Glycation Index and Cardiovascular Outcomes in Patients with Diabetes and Coronary Artery Disease: Insights from a Large Cohort Study. Nutrition & Diabetes, 14, Article No. 69. https://doi.org/10.1038/s41387-024-00318-x |
| [21] | Xu, S., Qin, Z., Yuan, R., Cui, X., Zhang, L., Bai, J., et al. (2022) The Hemoglobin Glycation Index Predicts the Risk of Adverse Cardiovascular Events in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus. Frontiers in Cardiovascular Medicine, 9, Article 992252. https://doi.org/10.3389/fcvm.2022.992252 |
| [22] | Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W. and Xu, H. (2022) Trends in Insulin Resistance: Insights into Mechanisms and Therapeutic Strategy. Signal Transduction and Targeted Therapy, 7, Article No. 216. https://doi.org/10.1038/s41392-022-01073-0 |
| [23] | 徐明成, 赵玉娟. 甘油三酯葡萄糖指数对动脉粥样硬化性心血管疾病的预测价值[J]. 心血管病学进展, 2023, 44(9): 810-813, 822. |
| [24] | Zhou, J., Huang, H., Huang, H., Peng, J., Chen, W., Chen, F., et al. (2024) Association of Triglyceride-Glucose Index and Its Combination with Adiposity-Related Indices with the Incidence of Myocardial Infarction: A Cohort Study from the UK Biobank. International Journal of Obesity, 48, 1498-1505. https://doi.org/10.1038/s41366-024-01612-5 |
| [25] | 白玉豪. TyG指数对ST段抬高型心肌梗死患者PCI术后院内发生主要心血管不良事件的预测价值[D]: [硕士学位论文]. 秦皇岛: 华北理工大学, 2022. |
| [26] | 图尔荪江∙伊卜拉伊木. AMI合并T2DM患者急诊PCI术后临床结局风险预测模型的建立和验证[D]: [硕士学位论文]. 乌鲁木齐: 新疆医科大学, 2022. |
| [27] | Ciresi, A., Amato, M.C., Pizzolanti, G. and Giordano Galluzzo, C. (2012) Visceral Adiposity Index Is Associated with Insulin Sensitivity and Adipocytokine Levels in Newly Diagnosed Acromegalic Patients. The Journal of Clinical Endocrinology & Metabolism, 97, 2907-2915. https://doi.org/10.1210/jc.2012-1518 |
| [28] | Er, L., Wu, S., Chou, H., Hsu, L., Teng, M., Sun, Y., et al. (2016) Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals. PLOS ONE, 11, e0149731. https://doi.org/10.1371/journal.pone.0149731 |
| [29] | Xia, X., Chen, S., Tian, X., Xu, Q., Zhang, Y., Zhang, X., et al. (2024) Association of Triglyceride-Glucose Index and Its Related Parameters with Atherosclerotic Cardiovascular Disease: Evidence from a 15-Year Follow-Up of Kailuan Cohort. Cardiovascular Diabetology, 23, Article No. 208. https://doi.org/10.1186/s12933-024-02290-3 |
| [30] | Liu, M., Pan, J., Meng, K., Wang, Y., Sun, X., Ma, L., et al. (2024) Triglyceride-Glucose Body Mass Index Predicts Prognosis in Patients with ST-Elevation Myocardial Infarction. Scientific Reports, 14, Article No. 976. https://doi.org/10.1038/s41598-023-51136-7 |
| [31] | Luo, C., Li, Q., Wang, Z., Duan, S. and Ma, Q. (2024) Association between Triglyceride Glucose-Body Mass Index and All-Cause Mortality in Critically Ill Patients with Acute Myocardial Infarction: Retrospective Analysis of the MIMIC-IV Database. Frontiers in Nutrition, 11, Article 1399969. https://doi.org/10.3389/fnut.2024.1399969 |
| [32] | 中华医学会糖尿病学分会, 国家基层糖尿病防治管理办公室. 国家基层糖尿病防治管理指南(2022) [J]. 中华内科杂志, 2022(3): 249-262. |
| [33] | Sardu, C., D’Onofrio, N., Torella, M., Portoghese, M., Loreni, F., Mureddu, S., et al. (2019) Pericoronary Fat Inflammation and Major Adverse Cardiac Events (MACE) in Prediabetic Patients with Acute Myocardial Infarction: Effects of Metformin. Cardiovascular Diabetology, 18, Article No. 126. https://doi.org/10.1186/s12933-019-0931-0 |
| [34] | Xu, Z., Zhang, H., Wu, C., Zheng, Y. and Jiang, J. (2022) Effect of Metformin on Adverse Outcomes in T2DM Patients: Systemic Review and Meta-Analysis of Observational Studies. Frontiers in Cardiovascular Medicine, 9, Article 944902. https://doi.org/10.3389/fcvm.2022.944902 |
| [35] | Mannucci, E., Gallo, M., Pintaudi, B., Targher, G., Candido, R., Giaccari, A., et al. (2022) All-Cause Mortality and Cardiovascular Events in Patients with Type 2 Diabetes Treated with Alpha-Glucosidase Inhibitors: A Meta-Analysis of Randomized Controlled Trials. Nutrition, Metabolism and Cardiovascular Diseases, 32, 511-514. https://doi.org/10.1016/j.numecd.2021.10.010 |
| [36] | Sattar, N., Lee, M.M.Y., Kristensen, S.L., Branch, K.R.H., Del Prato, S., Khurmi, N.S., et al. (2021) Cardiovascular, Mortality, and Kidney Outcomes with GLP-1 Receptor Agonists in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Trials. The Lancet Diabetes & Endocrinology, 9, 653-662. https://doi.org/10.1016/s2213-8587(21)00203-5 |
| [37] | Mannucci, E., Nreu, B., Montereggi, C., Ragghianti, B., Gallo, M., Giaccari, A., et al. (2021) Cardiovascular Events and All-Cause Mortality in Patients with Type 2 Diabetes Treated with Dipeptidyl Peptidase-4 Inhibitors: An Extensive Meta-Analysis of Randomized Controlled Trials. Nutrition, Metabolism and Cardiovascular Diseases, 31, 2745-2755. https://doi.org/10.1016/j.numecd.2021.06.002 |
| [38] | Broome, D.T. (2023) SGLT-2 Inhibitors: Discrepancy between MACE Reduction and Incident MI and Stroke. The Journal of Clinical Endocrinology & Metabolism, 108, e1450-e1451. https://doi.org/10.1210/clinem/dgad216 |
| [39] | Lin, D.S., Lee, J., Hung, C. and Chen, W. (2021) The Efficacy and Safety of Novel Classes of Glucose-Lowering Drugs for Cardiovascular Outcomes: A Network Meta-Analysis of Randomised Clinical Trials. Diabetologia, 64, 2676-2686. https://doi.org/10.1007/s00125-021-05529-w |
| [40] | Mannucci, E., Targher, G., Nreu, B., Pintaudi, B., Candido, R., Giaccari, A., et al. (2022) Effects of Insulin on Cardiovascular Events and All-Cause Mortality in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials. Nutrition, Metabolism and Cardiovascular Diseases, 32, 1353-1360. https://doi.org/10.1016/j.numecd.2022.03.007 |
| [41] | Staszewsky, L., Baviera, M., Tettamanti, M., Colacioppo, P., Robusto, F., D'Ettorre, A., et al. (2022) Insulin Treatment in Patients with Diabetes Mellitus and Heart Failure in the Era of New Antidiabetic Medications. BMJ Open Diabetes Research & Care, 10, e002708. https://doi.org/10.1136/bmjdrc-2021-002708 |
