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胆汁酸代谢在消化系统肿瘤中的影响及作用机制研究进展
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Abstract:
胆汁酸(BAs)对消化系统肿瘤的发生和发展具有重要影响。目前的研究已经证实，胆汁酸及其受体，如法尼醇X受体(FXR)和G蛋白偶联受体TGR5，在多种肿瘤的发生和发展中扮演着关键角色。此外，胆汁酸通过调节肿瘤微环境中的炎症反应和免疫反应，进一步影响肿瘤的进程。本文的目的是阐述胆汁酸与消化系统肿瘤发生发展的关系及其作用机制，主要通过氧化应激、DNA损伤、炎症反应、激活信号通路以及改变肿瘤微环境等途径，促进或抑制肿瘤的发展。我们总结了目前关于此领域研究的局限性，并为今后治疗肿瘤诊断标志物及治疗靶点提供新思路。
Bile acids (BAs) have an important impact on the occurrence and development of digestive system tumors. Current studies have confirmed that bile acids and their receptors, such as farnesol X receptor (FXR) and G protein-coupled receptor TGR5, play a key role in the development and progression of different tumors. In addition, bile acids further influence tumor progression by modulating inflammatory and immune responses in the tumor microenvironment. The purpose of this paper is to elucidate the relationship between bile acids and the development and mechanism of different digestive system tumors, which can promote or inhibit the development of tumors through oxidative stress, DNA damage, inflammatory response, activation of signaling pathways, and change of tumor microenvironment. We summarize the limitations of current research in this area, and provide new ideas for the future treatment of tumor diagnostic markers and therapeutic targets.
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