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慢性炎症在食管癌发生发展中的作用及机制研究进展
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Abstract:
食管癌是全球范围内高发且预后不良的恶性肿瘤之一。近年来，越来越多的研究表明，慢性炎症在食管癌的发生、发展和转移过程中扮演着关键角色。本文综述了慢性炎症在食管癌中的作用及其机制研究进展。胃酸/胆汁反流可诱发食管炎症，导致Barrett’s食管的形成。炎症细胞和炎性细胞因子，如IL-8、IL-6、TGF-β、IL-1β及TNF-α等，在食管炎、BE及EAC中发挥着关键作用。NF-κB和STAT3信号通路作为核心炎症信号通路，对食管癌的发生发展具有重要影响。此外，本文还讨论了未来的研究应深入探索炎症在食管癌进展中的机制，开发靶向药物和新的生物标志物，为食管癌的精准治疗提供新的策略与途径。
Esophageal cancer is one of the malignant tumors with high incidence and poor prognosis worldwide. In recent years, an increasing number of studies have indicated that chronic inflammation plays a crucial role in the occurrence, progression, and metastasis of esophageal cancer. This review article summarizes the role of chronic inflammation in esophageal cancer and the progress in research on its mechanisms. Gastroesophageal reflux of acid/bile can induce esophageal inflammation, leading to the formation of Barrett’s esophagus. Inflammatory cells and cytokines, such as IL-8, IL-6, TGF-β, IL-1β, and TNF-α, play key roles in esophagitis, BE (Barrett’s esophagus), and EAC (esophageal adenocarcinoma). The NF-κB and STAT3 signaling pathways, as core inflammatory pathways, significantly influence the development of esophageal cancer. Furthermore, this article discusses that future research should delve into the mechanisms of inflammation in the progression of esophageal cancer, develop targeted drugs and new biomarkers, and provide new strategies and approaches for precision treatment of esophageal cancer.
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