This study explores the application of fundamental physics to evaluate the conclusion that, in a microgravity environment, the bioavailability of current pharmacy in space pharmaceuticals can potentially double by excluding substrate concentrations during pharmaceutical preparation. If validated through prioritized vivo experiments or clinical trials, these findings could significantly advance research and development in pharmaceutical sciences.
References
[1]
Winter, M.E. Koda-Kimple, M.A., Young, L.Y. and Yanguas, E.P. (1994) Farmacocinética Clínica Básica. Ediciones Díaz de Santos, 8-14.
[2]
Volkenshtein, M.V., Dogonadze, R.R., Madumarov, A.K., Urushadze, Z.D. and Kharkats, Y.I. (1972) Theory of Enzyme Catalysis. MolekuliarnayaBiologia, 6, 431-439.
[3]
Volkenshtein, M.V., Dogonadze, R.R., Madumarov, A.K., Urushadze, Z.D., Kharkats, Yu.I. (1979) Electronic and Conformational Interactions in Enzyme Catalysis. In: Andronikashvili, E.L., Ed., Konformatsionnie Izmenenia Biopolimerov v Rastvorakh. Publishing House Nauka, 153-157.
[4]
Nomenclature Committee of the International Union of Biochemistry (NC-IUB) (1982) Symbolism and Terminology in Enzyme Kinetics Recommendations 1981. European Journal of Biochemistry, 128, 281-291. https://doi.org/10.1111/j.1432-1033.1982.tb06963.x
[5]
Nomenclature Committee of the International Union of Biochemistry (NC-IUB) (1983) Symbolism and Terminology in Enzyme Kinetics: Recommendations 1981. Archives of Biochemistry and Biophysics, 224, 732-740. https://doi.org/10.1016/0003-9861(83)90262-X
[6]
Nomenclature Committee of the International Union of Biochemistry (NC-IUB) (1982) Symbolism and Terminology in Enzyme Kinetics. Recommendations 1981. Biochemical Journal, 213, 561-571. https://doi.org/10.1042/bj2130561
[7]
Lehninger, A.L., Nelson, D.L. and Cox, M.M. (2005) Lehninger Principles of Biochemistry. W.H. Freeman.
[8]
Chakraborty, S. (2009) Microfluidics and Microfabrication. Springer.
[9]
Hebert, M.F. (2013) Impact of Pregnancy on Maternal Pharmacokinetics of Medications. In: Mattison, D.R., Ed., Clinical Pharmacology During Pregnancy, Elsevier, 17-39. https://doi.org/10.1016/B978-0-12-386007-1.00003-9
[10]
Griffin, J.P. (2009) The Textbook of Pharmaceutical Medicine. 6th Edition, BMJ Books.
[11]
Flynn, E. (2007) Pharmacokinetic Parameters. In: Enna, S.J. and David, B., Eds., xPharm: The Comprehensive Pharmacology Reference, Elsevier,1-3. https://doi.org/10.1016/B978-008055232-3.60034-0
Johanson, G. (2010) Modeling of Disposition. Comprehensive Toxicology, 1, 153-177. https://doi.org/10.1016/B978-0-08-046884-6.00108-1
[14]
Robert, P.H. (2001) Factors Influencing the Measurement of Bioavailability, Taking Calcium as a Model. The Journal of Nutrition, 131, 1344S-1348S. https://doi.org/10.1093/jn/131.4.1344S
