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基于多学科探讨早泄与情志之“郁”关系
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Abstract:
目的:早泄作为男科常见病,诸多学者对其发病机理、治疗转归进行研究,发现情志因素具有较大影响。然基于学科间的差异,各学者的研究局限于自己所属领域。行文旨在基于多学科视角,将中医理论与现代生理、药理、心理学研究相结合,探求早泄一病与情志关联。方法:笔者检索、阅读近20年内各学科研究早泄病的相关文献,将其系统归纳、总结、提炼。结果:通过整理、分析发现,传统中医对早泄与情志之“郁”的联系已有一定认识,现代生理、药理学证实这些认识的合理性和实践意义。心理学亦认为早泄与情志和心理状态密切相关。结论:情志之“郁”在早泄病的发生治疗转归中有着重要影响,可进一步研究。
Objective: Premature ejaculation, as a common male urological condition, has been extensively studied by many scholars regarding its etiology and treatment outcomes, revealing a significant influence of psychological factors. However, due to disciplinary differences, the research of various scholars has been limited to their respective fields. This paper aims to integrate traditional Chinese medicine theories with modern physiological, pharmacological, and psychological research from a multidisciplinary perspective to explore the association between premature ejaculation and emotional factors. Methods: The author conducted a literature search and review of relevant studies on premature ejaculation conducted in various disciplines over the past 20 years. The findings were systematically organized, summarized, and refined. Results: Through organization and analysis, it was found that traditional Chinese medicine has already recognized the connection between premature ejaculation and the emotional aspect of “depression.” Modern physiology and pharmacology have confirmed the rationality and practical significance of these understandings. Psychology also acknowledges the close relationship between premature ejaculation and emotional and psychological states. Conclusion: The emotional aspect of “depression” plays an important role in the occurrence, treatment, and prognosis of premature ejaculation, warranting further research.
[1] | 早泄诊断与治疗指南[J]. 中华男科学杂志, 2022, 28(7): 656-657. |
[2] | 中华医学会男科学分会. 中国男科疾病诊断治疗指南与专家共识(2016版) [J]. 北京: 人民卫生出版社, 2018: 58. |
[3] | 尹霖, 张喜玲, 王全, 洪志明, 陈德宁. 陈德宁教授运用安心神法治疗早泄的临床经验[J]. 中华中医药学刊, 2012, 30(9): 1932-1934. |
[4] | 杜冠潮, 邓楹君, 赵丰, 郭俊, 王浩, 郭军. 基于肠道菌群探讨早泄从脾胃论治[J]. 中国性科学, 2021, 30(5): 118-120. |
[5] | 赵伟, 王庆, 章茂森. 徐福松教授从胃论治早泄经验[J]. 中华男科学杂志, 2017, 23(10): 951-953. |
[6] | 刘建国, 李姣姣. 早泄从痰论治[J]. 中国性科学, 2021, 30(11): 113-116. |
[7] | 张天宇, 卢桂林, 杨凯, 董盼攀, 曾庆琪. 曾庆琪从躁郁论治早泄与阳痿[J]. 中国中医基础医学杂志, 2020, 26(11): 1728-1730. |
[8] | Haleem, D.J. (2011) Behavioral Deficits and Exaggerated Feedback Control over Raphe-Hippocampal Serotonin Neurotransmission in Restrained Rats. Pharmacological Reports, 63, 888-897. https://doi.org/10.1016/s1734-1140(11)70604-1 |
[9] | Jeong, I., Yang, J.S., Hong, Y.J., Kim, H.J., Hahn, S.J. and Yoon, S.H. (2017) Dapoxetine Induces Neuroprotective Effects against Glutamate-Induced Neuronal Cell Death by Inhibiting Calcium Signaling and Mitochondrial Depolarization in Cultured Rat Hippocampal Neurons. European Journal of Pharmacology, 805, 36-45. https://doi.org/10.1016/j.ejphar.2017.03.033 |
[10] | Gao, J., Peng, D., Zhang, X., Hao, Z., Zhou, J., Fan, S., et al. (2016) Prevalence and Associated Factors of Premature Ejaculation in the Anhui Male Population in China: Evidence-Based Unified Definition of Lifelong and Acquired Premature Ejaculation. Sexual Medicine, 5, e37-e43. https://doi.org/10.1016/j.esxm.2016.11.002 |
[11] | 蔡海荣, 黄翔, 章晓蓉. 早泄与血中单胺类神经递质关系的相关性研究[J]. 中国现代医生, 2018, 56(7): 20-23. |
[12] | Heinrichs, M., Baumgartner, T., Kirschbaum, C. and Ehlert, U. (2003) Social Support and Oxytocin Interact to Suppress Cortisol and Subjective Responses to Psychosocial Stress. Biological Psychiatry, 54, 1389-1398. https://doi.org/10.1016/s0006-3223(03)00465-7 |
[13] | Furman, D.J., Chen, M.C. and Gotlib, I.H. (2011) Variant in Oxytocin Receptor Gene Is Associated with Amygdala Volume. Psychoneuroendocrinology, 36, 891-897. https://doi.org/10.1016/j.psyneuen.2010.12.004 |
[14] | Waldinger, M.D. (2016) The Pathophysiology of Lifelong Premature Ejaculation. Translational Andrology and Urology, 5, 424-433. https://doi.org/10.21037/tau.2016.06.04 |
[15] | McMahon, C.G., Jannini, E.A., Serefoglu, E.C. and Hellstrom, W.J.G. (2016) The Pathophysiology of Acquired Premature Ejaculation. Translational Andrology and Urology, 5, 434-449. https://doi.org/10.21037/tau.2016.07.06 |
[16] | 高攀. 组蛋白5-羟色胺化介导DRD4上调在射精调控中的作用及机制研究[D]: [博士学位论文]. 合肥: 安徽医科大学, 2022. |
[17] | 赵肖帆. 早泄的中医文献研究[D]: [硕士学位论文]. 北京: 北京中医药大学, 2016. |
[18] | 耿金海. 早泄患者中医证素及相关因素分布初步探讨[D]: [硕士学位论文]. 北京: 北京中医药大学, 2020. |
[19] | 王锋, 张丽娜. 疏肝解郁法治疗早泄临床观察[J]. 中医临床研究, 2015, 7(18): 64-65. |
[20] | 薛鹏飞, 张玲, 尤耀东. 早泄的中医药特色疗法浅析[J]. 中国民间疗法, 2021(8): 122-125. |
[21] | 赵凡, 张春和, 孙迪, 黄子彦. 早泄之“心-肝-肾”调治观[J]. 中国中医基础医学杂志, 2022, 28(6): 998-1001. |
[22] | 刘妍, 杨丽廷, 龙文杰, 王陵军, 汪朝晖. 基于数据挖掘技术研究中药治疗早泄的规律[J]. 中华男科学杂志, 2020, 26(7): 650-655. |
[23] | 张继伟, 李秋艳, 王浩, 杜冠潮, 于文晓, 郭军. 基于国家专利数据库中药复方治疗早泄的用药规律研究[J]. 中国男科学杂志, 2022, 36(4): 22-28+35. |
[24] | 彭申明, 陈勤, 陈逸青, 叶海燕, 王亭. 菟丝子总黄酮对内分泌衰退痴呆模型小鼠学习记忆功能的影响及保护作用机制[J]. 激光生物学报, 2014, 23(3): 218-226. |
[25] | 张聪, 卢慧勤, 胡楚璇, 梅清华, 张霞, 黄晓玲. 淫羊藿苷对慢性不可预知温和刺激诱导的大鼠抑郁行为和神经递质水平的影响[J]. 中国药学杂志, 2018, 53(15): 1280-1284. |
[26] | 孟胜喜, 霍清萍. 肉苁蓉有效成分对神经系统作用研究进展[J]. 中国中医药信息杂志, 2016, 23(10): 123-126. |
[27] | 樊晓蕾, 汤轶波, 白雪, 陈亚飞, 刘丹, 刘桂敏, 刘柘君, 李玲孺, 郑燕飞, 刘振权. 数据挖掘分析国医大师王琦院士治疗早泄的用药经验[J]. 中华男科学杂志, 2021, 27(11): 1017-1024. |
[28] | 刘军. 王琦运用宁神定志法治疗早泄[J]. 中医杂志, 2001(7): 420. |
[29] | 邓省, 王继升, 代恒恒, 鲍丙豪, 于旭东, 冯隽龙, 王彬, 李海松. 基于数据挖掘分析李曰庆教授治疗早泄的用药特点与规律[J]. 世界中西医结合杂志, 2021, 16(9): 1589-1592+1605. |
[30] | 梁天豪, 丘勇超. 崔学教论治早泄经验[J]. 中医学报, 2019, 34(12): 2580-2583+2592. |
[31] | 周海亮, 何清湖, 周兴, 李波男, 谭新华. 谭新华教授御神论治早泄临证思维[J]. 中国中医药现代远程教育, 2019, 17(19): 48-50. |
[32] | 盛文, 李宪锐, 丁劲, 商建伟. 李曰庆教授从心肝肾论治早泄的经验[J]. 中国性科学, 2017, 26(5): 93-95. |
[33] | 车晓艳, 张恩思, 张银, 崇武. 早泄患者人格特征及心理状况的调查与分析[J]. 中华男科学杂志, 2019(11): 996-1000. |
[34] | 伍鼎. 早泄患者心理因素的探讨[D]: [硕士学位论文]. 南充: 川北医学院, 2017. |
[35] | 姜大业, 倪颖. 常规治疗联合心理-行为疗法治疗早泄的临床研究[J]. 中国性科学, 2018(10): 14-16. |
[36] | 焦薇薇, 王浩浩, 鲁喦, 邱文然, 王杰, 曾杰, 王传航. 早泄的房中术行为疗法[J]. 中国民间疗法, 2021(4): 8-10. |
[37] | 董俊强. 早泄与焦虑、抑郁相关性研究[D]: [硕士学位论文]. 大连: 大连医科大学, 2012. |
[38] | 于文晓, 晏斌, 王浩, 杜冠潮, 任凯, 郭军. 基于“脑-心-肾-精室”轴辨治早泄的理论研究与思路[J]. 陕西中医, 2022, 43(10): 1427-1431. |
[39] | 毕焕洲, 李香斌, 于珊珊, 黄念文. 早泄从神论治[J]. 中国中医药科技, 2022, 29(3): 397-400. |
[40] | Wei, S., Ma, M., Wen, X., Wu, C., Zhu, G. and Zhou, X. (2021) Online Public Attention toward Premature Ejaculation in Mainland China: Infodemiology Study Using the Baidu Index. Journal of Medical Internet Research, 23, e30271. https://doi.org/10.2196/30271 |