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针灸干预铁死亡治疗心肌缺血–再灌注损伤的进展和机制探讨
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Abstract:
经皮冠状动脉介入术(Percutaneous Coronary Intervention, PCI)等再灌注治疗，是挽救缺血心肌、改善心脏功能的重要手段。但心肌缺血一段时间后恢复灌注，会造成额外损伤，加重心脏功能障碍与结构破坏，即心肌缺血–再灌注损伤(MIRI)。MIRI是一个重大的临床问题，它直接关系到患者的临床获益水平，对患者的康复和预后有着深远的影响。因此，深入研究心肌缺血–再灌注损伤的机制，开发有效的预防和治疗策略，对于提高患者的治疗效果和生活质量具有极其重要的意义。研究发现铁死亡存在于MIRI过程中，抑制铁死亡的发生可以减轻MIRI。本文就针灸干预铁死亡治疗MIRI的进展和机制探讨，以期为研究针刺治疗MIRI的机制提供新的思路。
Percutaneous coronary intervention, such as percutaneous coronary intervention, is an important means to save ischemic myocardium and improve cardiac function. However, reperfusion after a period of myocardial ischemia may exacerbate cardiac dysfunction and structural damage, a phenomenon termed myocardial ischemia-reperfusion injury (MIRI). MIRI is a major clinical issue, which is directly related to the level of clinical benefit of patients and profoundly affects patients’ recovery and prognosis. Therefore, it is of great significance to study the mechanism of myocardial ischemia-reperfusion injury and develop effective prevention and treatment strategies to improve the treatment effect and quality of life of patients. Ferroptosis has been found to be present during MIRI, and inhibition of ferroptosis can alleviate MIRI. This article discusses the progress and mechanism of acupuncture intervention in ferroptosis treatment of MIRI in order to provide new ideas for the study of the mechanism of acupuncture treatment of MIRI.
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