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维生素C对糖尿病小鼠视网膜的保护作用
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Abstract:
糖尿病视网膜病变(Diabetic Retinopathy, DR)是糖尿病的主要微血管并发症，慢性炎症和细胞凋亡在其发生发展中起关键作用。研究表明，维生素C具有抗氧化和抗炎特性，可能有助于缓解DR相关的视网膜损伤。然而，其在DR体内模型中的保护作用仍不明确。本研究采用链脲佐菌素(Streptozotocin, STZ)诱导糖尿病小鼠模型，检测维生素C干预对视网膜组织结构及炎症因子表达的影响。结果表明，维生素C通过减少TNF-α、IL-1β、IL-6和MCP-1的表达水平，减轻炎症反应，同时抑制视网膜神经细胞凋亡并改善视网膜厚度。研究揭示了维生素C可能通过抗炎和抗凋亡机制对DR产生保护作用，为其作为辅助治疗提供了实验依据。
Diabetic retinopathy (DR) is a major microvascular complication of diabetes, with chronic inflammation and cell apoptosis playing key roles in its pathogenesis. Vitamin C has antioxidant and anti-inflammatory properties, and may help alleviate retinal damage associated with DR. However, its protective effects in DR animal models are still unclear. In this study, a STZ-induced diabetic mouse model was used to examine the impact of vitamin C intervention on retinal tissue structure and inflammatory cytokine expression. The results showed that vitamin C significantly reduced the expression levels of TNF-α, IL-1β, IL-6, and MCP-1, alleviating inflammation, while inhibiting retinal neuronal cell apoptosis and improving retinal thickness. The study suggests that vitamin C may exert protective effects on DR through anti-inflammatory and anti-apoptotic mechanisms, providing experimental support for its use as an adjunctive therapy.
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