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Bioprocess 2025
LncRNA与脂代谢在结直肠癌中的研究进展
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Abstract:
长链非编码RNA (lncRNA)是长度超过200个核苷酸的功能性非编码RNA，与癌症等多种严重危害人类健康的重大疾病密切相关。LncRNA可通过多种机制发挥广泛的调控作用，作为癌基因或抑癌基因调节肿瘤细胞的增殖、侵袭和转移等，进而调控肿瘤的发生、发展。而结直肠癌是我国一类常见的恶性肿瘤。LncRNA还是脂代谢的关键调节因子，可以调节肿瘤细胞的脂肪从头合成和脂肪酸氧化，进而影响结直肠癌进展。此外，lncRNA还参与调控结直肠癌中多条信号通路的表达，从而调节其脂代谢，对结直肠癌细胞的生物学活性产生影响。本文总结梳理近些年关于lncRNA在结直肠癌脂代谢中的调控作用，特别是在脂代谢关键酶及相关信号通路中的研究。此外，我们还讨论了lncRNA在结直肠癌诊断、治疗及预后的前景，为结直肠癌及消化道肿瘤的防治研究及临床应用提供新的思路。
Long non-coding RNA (lncRNA) is functional non-coding RNA with a length of more than 200 nucleotides, which are closely associated with a variety of serious diseases that seriously endanger human health, such as cancer. LncRNA can play a wide range of regulatory roles through a variety of mechanisms, acting as oncogenes or tumor suppressors to regulate the proliferation, invasion, and metastasis of tumor cells, and so on, and then regulate the occurrence and development of tumors. Colorectal cancer is one of the most common malignant tumors in China. LncRNA is also a key regulator of lipid metabolism, which can regulate the de novo synthesis of fat in tumour cells, alter lipid storage and fatty acid oxidation, and thus affect the progression of colorectal cancer. In addition, lncRNA is also involved in regulating the expression of multiple signaling pathways in colorectal cancer, thereby regulating their lipid metabolism, and influencing the biological activity of colorectal cancer cells. In this review, we summarize and sort out the regulatory roles of lncRNA in lipid metabolism of colorectal cancer in recent years, especially in key enzymes of lipid metabolism and signaling pathways related to lipid metabolism. In addition, we discuss the prospects of lncRNA in the diagnosis, therapy and prognosis of colorectal cancer, and provide new ideas for the prevention and therapy research and clinical application of colorectal cancer.
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