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颗粒蛋白前体参与肾脏损伤的相关研究进展
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Abstract:
肾脏疾病是临床上最常见的疾病之一，包含原发性和继发性等多种分类，具有多种表现。其进展至终末期肾衰竭将严重危害人类健康，因此对其发病机制的探讨研究以及寻求有效延缓疾病进展的治疗手段意义重大。颗粒蛋白前体(progranulin, PGRN)是一种富含半胱氨酸的分泌蛋白，广泛表达于多种组织及细胞中，在神经退行性变、肿瘤形成、免疫调节、炎症中发挥重要的作用。最近有研究发现，颗粒蛋白前体在肾脏疾病中也具有重要作用。本文总结了近年来PGRN在肾脏损伤方面的研究，以期对临床肾脏病的防治提供新的方向。
Kidney disease is one of the most common clinical conditions, encompassing primary and secondary classifications, among others, and presents with a variety of manifestations. Its progression to end-stage renal failure poses a serious threat to human health, making the exploration of its pathogenesis and the search for effective treatments to delay disease progression of significant importance. Progranulin (PGRN), a cysteine-rich secretory protein, is widely expressed in various tissues and cells and plays a crucial role in neurodegeneration, tumor formation, immune regulation, and inflammation. Recent studies have found that progranulin also plays an important role in kidney diseases. This article summarizes recent research on PGRN in kidney injury, aiming to provide new directions for the prevention and treatment of clinical kidney diseases.
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