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伴有咽喉部症状的胃食管反流病的研究进展
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Abstract:
胃食管反流病(GERD)是一种常见病，除了反酸和烧心这些典型症状，患者越来越多地表现为慢性咳嗽、咽部异物感、声音嘶哑、哮喘、吞咽困难等咽喉部症状，这些症状发生的病理生理机制尚未明确，且以其为主要表现的GERD患者的诊断及治疗方案尚未标准化。文章主要概述了伴有咽喉部症状的GERD患者的发病机制、当前的诊断方式和治疗方案，为其早发现、早诊断、早治疗提供思路。
Gastroesophageal reflux disease (GERD) is a prevalent condition characterized not only by typical symptoms such as acid regurgitation and heartburn, but also increasingly by laryngeal manifestations including chronic cough, globus sensation in the throat, hoarseness, asthma, and dysphagia. The pathophysiological mechanisms underlying these laryngeal symptoms remain unclear, and standardized diagnostic criteria and therapeutic strategies for GERD patients predominantly presenting with these symptoms have yet to be established. This article provides an overview of the pathogenesis, current diagnostic methods, and treatment modalities for GERD patients with laryngeal symptoms, offering insights into early detection, diagnosis, and management of the condition.
| [1] | Vakil, N., van Zanten, S.V., Kahrilas, P., Dent, J. and Jones, R. (2006) The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus. The American Journal of Gastroenterology, 101, 1900-1920. https://doi.org/10.1111/j.1572-0241.2006.00630.x |
| [2] | Zhang, D., Liu, S., Li, Z. and Wang, R. (2022) Global, Regional and National Burden of Gastroesophageal Reflux Disease, 1990-2019: Update from the GBD 2019 Study. Annals of Medicine, 54, 1372-1384. https://doi.org/10.1080/07853890.2022.2074535 |
| [3] | 汪忠镐, 吴继敏, 胡志伟, 等. 中国胃食管反流病多学科诊疗共识[J]. 中华胃食管反流病电子杂志, 2020, 7(1): 1-28. |
| [4] | Hom, C. and Vaezi, M.F. (2013) Extra-Esophageal Manifestations of Gastroesophageal Reflux Disease: Diagnosis and Treatment. Drugs, 73, 1281-1295. https://doi.org/10.1007/s40265-013-0101-8 |
| [5] | 肖英莲. 胃食管反流性咳嗽的内科治疗进展[J]. 中华结核和呼吸杂志, 2023, 46(10): 958-961. |
| [6] | Griffiths, T.L., Nassar, M. and Soubani, A.O. (2020) Pulmonary Manifestations of Gastroesophageal Reflux Disease. Expert Review of Respiratory Medicine, 14, 767-775. https://doi.org/10.1080/17476348.2020.1758068 |
| [7] | Kahrilas, P.J. (2010) Chronic Cough and Gastroesophageal Reflux Disease: New Twists to the Riddle. Gastroenterology, 139, 716-718. https://doi.org/10.1053/j.gastro.2010.07.014 |
| [8] | Kopsaftis, Z., Yap, H.S., Tin, K.S., Hnin, K. and Carson-Chahhoud, K.V. (2021) Pharmacological and Surgical Interventions for the Treatment of Gastro-Oesophageal Reflux in Adults and Children with Asthma. Cochrane Database of Systematic Reviews, 5, CD001496. https://doi.org/10.1002/14651858.cd001496.pub2 |
| [9] | Lupu, V.V., Miron, I.C., Lupu, A., Moscalu, M., Mitrofan, E.C., Munteanu, D., et al. (2021) The Relationship between Gastroesophageal Reflux Disease and Recurrent Wheezing in Children. Medicine, 100, e27660. https://doi.org/10.1097/md.0000000000027660 |
| [10] | 陈燕燕, 陈玉赞, 王涛. 心理因素对反流性咽喉炎转归的影响 [J]. 中国现代医生, 2016, 54(14): 68-71. |
| [11] | Naik, R.D. and Vaezi, M.F. (2015) Extra-Esophageal Gastroesophageal Reflux Disease and Asthma: Understanding This Interplay. Expert Review of Gastroenterology & Hepatology, 9, 969-982. https://doi.org/10.1586/17474124.2015.1042861 |
| [12] | Wu, J., Ma, Y. and Chen, Y. (2022) Gerd-Related Chronic Cough: Possible Mechanism, Diagnosis and Treatment. Frontiers in Physiology, 13, Article 1005404. https://doi.org/10.3389/fphys.2022.1005404 |
| [13] | 袁莉莉. 合并食管外症状的难治性胃食管反流病患者食管动力和反流特点分析[D]: [硕士学位论文]. 郑州: 郑州大学, 2020. |
| [14] | Ates, F. and Vaezi, M.F. (2013) Approach to the Patient with Presumed Extraoesophageal Gerd. Best Practice & Research Clinical Gastroenterology, 27, 415-431. https://doi.org/10.1016/j.bpg.2013.06.009 |
| [15] | Eapen, A.A., Gupta, M.R., Lockey, R.F., Bardin, P.G. and Baptist, A.P. (2024) Gastroesophageal Reflux Disease, Laryngopharyngeal Reflux, and Vocal Cord Dysfunction/inducible Laryngeal Obstruction—Overlapping Conditions that Affect Asthma. Journal of Allergy and Clinical Immunology, 154, 1369-1377. https://doi.org/10.1016/j.jaci.2024.10.006 |
| [16] | de Bortoli, N. (2012) How Many Cases of Laryngopharyngeal Reflux Suspected by Laryngoscopy Are Gastroesophageal Reflux Disease-Related? World Journal of Gastroenterology, 18, 4363-4370. https://doi.org/10.3748/wjg.v18.i32.4363 |
| [17] | 徐晓蓉, 李兆申. 胃食管反流病消化道外症状发病机制与诊治[J]. 国外医学(消化系疾病分册), 2004, 24(2): 90-92. |
| [18] | Adhami, T., Goldblum, J.R., Richter, J.E. and Vaezi, M.F. (2004) The Role of Gastric and Duodenal Agents in Laryngeal Injury: An Experimental Canine Model. The American Journal of Gastroenterology, 99, 2098-2106. https://doi.org/10.1111/j.1572-0241.2004.40170.x |
| [19] | Ing, A.J., Ngu, M.C. and Breslin, A.B. (1994) Pathogenesis of Chronic Persistent Cough Associated with Gastroesophageal Reflux. American Journal of Respiratory and Critical Care Medicine, 149, 160-167. https://doi.org/10.1164/ajrccm.149.1.8111576 |
| [20] | Cazzola, M., Rogliani, P., Ora, J., Calzetta, L. and Matera, M.G. (2022) Asthma and Comorbidities: Recent Advances. Polish Archives of Internal Medicine, 132, Article ID: 16250. https://doi.org/10.20452/pamw.16250 |
| [21] | Pauwels, A., Blondeau, K., Dupont, L. and Sifrim, D. (2009) Cough and Gastroesophageal Reflux: From the Gastroenterologist End. Pulmonary Pharmacology & Therapeutics, 22, 135-138. https://doi.org/10.1016/j.pupt.2008.11.007 |
| [22] | Vaezi, M.F., Katzka, D. and Zerbib, F. (2018) Extraesophageal Symptoms and Diseases Attributed to GERD: Where Is the Pendulum Swinging Now? Clinical Gastroenterology and Hepatology, 16, 1018-1029. https://doi.org/10.1016/j.cgh.2018.02.001 |
| [23] | 曹芝君. 胃-食管反流病的咽喉部表现[J]. 国外医学(消化系疾病分册), 1999(2): 67-69. |
| [24] | Knight, R.E., Wells, J.R. and Parrish, R.S. (2000) Esophageal Dysmotility as an Important Co‐Factor in Extraesophageal Manifestations of Gastroesophageal Reflux. The Laryngoscope, 110, 1462-1466. https://doi.org/10.1097/00005537-200009000-00010 |
| [25] | Patcharatrakul, T. and Gonlachanvit, S. (2014) Gastroesophageal Reflux Symptoms in Typical and Atypical Gerd: Roles of Gastroesophageal Acid Refluxes and Esophageal Motility. Journal of Gastroenterology and Hepatology, 29, 284-290. https://doi.org/10.1111/jgh.12347 |
| [26] | Diener, U., Patti, M.G., Molena, D., Fisichella, P.M. and Way, L.W. (2001) Esophageal Dysmotility and Gastroesophageal Reflux Disease. Journal of Gastrointestinal Surgery, 5, 260-265. https://doi.org/10.1016/s1091-255x(01)80046-9 |
| [27] | 陈蓉蓉, 冯奔畅, 王佳浩, 等. 合并咽喉症状胃食管反流病患者的临床特征分析[J]. 胃肠病学, 2022, 27(7): 392-398. |
| [28] | Bennett, M.C., Patel, A., Sainani, N., Wang, D., Sayuk, G.S. and Gyawali, C.P. (2018) Chronic Cough Is Associated with Long Breaks in Esophageal Peristaltic Integrity on High-Resolution Manometry. Journal of Neurogastroenterology and Motility, 24, 387-394. https://doi.org/10.5056/jnm17126 |
| [29] | Gyawali, C.P., Kahrilas, P.J., Savarino, E., Zerbib, F., Mion, F., Smout, A.J.P.M., et al. (2018) Modern Diagnosis of GERD: The Lyon Consensus. Gut, 67, 1351-1362. https://doi.org/10.1136/gutjnl-2017-314722 |
| [30] | 阿丽米热·艾尔肯, 邱忠民. “里昂共识”对胃食管反流性咳嗽诊断能力提升的推动效用[J]. 国际呼吸杂志, 2023, 43(8): 886-890. |
| [31] | 郭宇佳, 郑吉敏. 胃食管反流性咳嗽发病机制的研究进展[J]. 世界最新医学信息文摘, 2019, 19(52): 96-97. |
| [32] | Lee, B.E. (2012) Globus Pharyngeus: A Review of Its Etiology, Diagnosis and Treatment. World Journal of Gastroenterology, 18, 2462-2471. https://doi.org/10.3748/wjg.v18.i20.2462 |
| [33] | Harris, M.B., Deary, I.J. and Wilson, J.A. (1996) Life Events and Difficulties in Relation to the Onset of Globus Pharyngis. Journal of Psychosomatic Research, 40, 603-615. https://doi.org/10.1016/0022-3999(96)00024-4 |
| [34] | Hoon Park, K., Myung Choi, S., Kwon, S., Won Yoon, S. and Kim, S. (2006) Diagnosis of Laryngopharyngeal Reflux among Globus Patients. Otolaryngology—Head and Neck Surgery, 134, 81-85. https://doi.org/10.1016/j.otohns.2005.08.025 |
| [35] | Siupsinskiene, N., Adamonis, K., Toohill, R.J. and Sereika, R. (2008) Predictors of Response to Short-Term Proton Pump Inhibitor Treatment in Laryngopharyngeal Reflux Patients. The Journal of Laryngology & Otology, 122, 1206-1212. https://doi.org/10.1017/s0022215108001898 |
| [36] | Hill, J., Stuart, R.C., Fung, H.K., Ng, E.K.W., Cheung, F.M., Chung, S.C.S., et al. (1997) Gastroesophageal Reflux, Motility Disorders, and Psychological Profiles in the Etiology of Globus Pharyngis. The Laryngoscope, 107, 1373-1377. https://doi.org/10.1097/00005537-199710000-00015 |
| [37] | 张利, 阿丽米热·艾尔肯, 邱忠民. 关于胃食管反流性咳嗽诊断方法与标准的探讨[J]. 中华结核和呼吸杂志, 2023, 46(10): 954-957. |
| [38] | Vaezi, M.F. and Sifrim, D. (2018) Assessing Old and New Diagnostic Tests for Gastroesophageal Reflux Disease. Gastroenterology, 154, 289-301. https://doi.org/10.1053/j.gastro.2017.07.040 |
| [39] | 陈思旭, 林忆萍, 郝建宇, 等. 以食管外症状为主要表现的胃食管反流病诊断方法的研究进展[J]. 中华胃食管反流病电子杂志, 2021, 8(1): 32-36. |
| [40] | 韩悦, 张森, 皇甫辉, 等. 咽喉反流性疾病诊断量表的应用进展[J]. 临床耳鼻咽喉头颈外科杂志, 2023, 37(4): 313-317. |
| [41] | 周莹, 王丽萍, 宁平, 等. 咽喉反流与发声障碍的相关性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2012, 26(3): 97-101. |
| [42] | Manka, L.A., Guntur, V.P., Stevens, A.D., Kolakowski, C., Moore, C.M. and Martin, R.J. (2025) The Supraglottic Index: An Indicator of Response to Laryngopharyngeal Reflux Therapy in Asthma. Annals of Allergy, Asthma & Immunology, 134, 209-214.e2. https://doi.org/10.1016/j.anai.2024.10.012 |
| [43] | 胡志伟, 吴继敏, 汪忠镐. 胃食管气道反流性疾病:如何提高我国胃食管反流相关呼吸道症状的诊疗水平[J]. 临床内科杂志, 2021, 38(6): 361-363. |
| [44] | Calabrese, F., Pasta, A., Bodini, G., Furnari, M., Zentilin, P., Giannini, E.G., et al. (2024) Applying Lyon Consensus Criteria in the Work‐up of Patients with Extra‐oesophageal Symptoms—A Multicentre Retrospective Study. Alimentary Pharmacology & Therapeutics, 59, 1134-1143. https://doi.org/10.1111/apt.17934 |
| [45] | Hom, C. and Vaezi, M.F. (2013) Extraesophageal Manifestations of Gastroesophageal Reflux Disease. Gastroenterology Clinics of North America, 42, 71-91. https://doi.org/10.1016/j.gtc.2012.11.004 |
| [46] | 李兆申, 徐晓蓉, 邹多武, 等. 胃食管反流病食管外表现的临床研究[J]. 中华内科杂志, 2006, 45(1): 13-16. |
| [47] | Katz, P.O., Gerson, L.B. and Vela, M.F. (2013) Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease. American Journal of Gastroenterology, 108, 308-328. https://doi.org/10.1038/ajg.2012.444 |
| [48] | Gyawali, C.P., Yadlapati, R., Fass, R., Katzka, D., Pandolfino, J., Savarino, E., et al. (2023) Updates to the Modern Diagnosis of GERD: Lyon Consensus 2.0. Gut, 73, 361-371. https://doi.org/10.1136/gutjnl-2023-330616 |
| [49] | Vakil, N., Vieth, M., Wernersson, B., Wissmar, J. and Dent, J. (2017) Diagnosis of Gastro‐Oesophageal Reflux Disease Is Enhanced by Adding Oesophageal Histology and Excluding Epigastric Pain. Alimentary Pharmacology & Therapeutics, 45, 1350-1357. https://doi.org/10.1111/apt.14028 |
| [50] | 覃秀敏, 余晓云. HGMUE的相关研究[J]. 临床医学进展, 2024, 14(5): 2341-2346. |
| [51] | Wang, W., Liu, Q., Luo, L., Huang, J., Hu, X., Zhou, Z., et al. (2024) Value of Endoscopic Grading of Gastroesophageal Flap Valve in Gastroesophageal Reflux Disease. Surgical Endoscopy, 38, 4956-4964. https://doi.org/10.1007/s00464-024-10839-2 |
| [52] | Wu, W., Li, L., Qu, C., Wang, M., Liang, S., Gao, X., et al. (2019) Reflux Finding Score Is Associated with Gastroesophageal Flap Valve Status in Patients with Laryngopharyngeal Reflux Disease: A Retrospective Study. Scientific Reports, 9, Article No. 15744. https://doi.org/10.1038/s41598-019-52349-5 |
| [53] | Durazzo, M., Lupi, G., Cicerchia, F., Ferro, A., Barutta, F., Beccuti, G., et al. (2020) Extra-Esophageal Presentation of Gastroesophageal Reflux Disease: 2020 Update. Journal of Clinical Medicine, 9, Article 2559. https://doi.org/10.3390/jcm9082559 |
| [54] | Loganathan, P., Gajendran, M., Perisetti, A., Goyal, H., Mann, R., Wright, R., et al. (2024) Endoscopic Advances in the Diagnosis and Management of Gastroesophageal Reflux Disease. Medicina, 60, Article 1120. https://doi.org/10.3390/medicina60071120 |
| [55] | Salvador, R., Capovilla, G., Santangelo, M., Vittori, A., Forattini, F., Provenzano, L., et al. (2024) Manometric Identikit of a Functioning and Effective Fundoplication for Gastroesophageal Reflux Disease in the High‐Resolution Manometry Era. United European Gastroenterology Journal, 12, 749-760. https://doi.org/10.1002/ueg2.12553 |
| [56] | 中国医师协会外科医师分会胃食管反流病专业委员会. 成人胃食管反流病外科诊疗共识(2020版) [J]. 中华胃食管反流病电子杂志, 2021, 8(1): 1-8. |
| [57] | Siboni, S., Kristo, I., Rogers, B.D., De Bortoli, N., Hobson, A., Louie, B., et al. (2023) Improving the Diagnostic Yield of High-Resolution Esophageal Manometry for GERD: The “Straight Leg-Raise” International Study. Clinical Gastroenterology and Hepatology, 21, 1761-1770.e1. https://doi.org/10.1016/j.cgh.2022.10.008 |
| [58] | Siboni, S., Sozzi, M., Kristo, I., Boveri, S., Rogers, B.D., De Bortoli, N., et al. (2024) The Milan Score: A Novel Manometric Tool for a More Efficient Diagnosis of Gastro‐Esophageal Reflux Disease. United European Gastroenterology Journal, 12, 552-561. https://doi.org/10.1002/ueg2.12565 |
| [59] | 马进玉, 齐颖, 邸岩, 等. 食管动力在咽喉反流发生中的作用[J]. 世界华人消化杂志, 2009, 17(34): 3543-3546. |
| [60] | 张艳丽, 郑岳, 朱慧婷, 等. 合并或不合并食管外症状的胃食管反流病患者食管动力与反流特征及机制探讨[J]. 中华医学杂志, 2018, 98(44): 3579-3583. |
| [61] | Färkkilä, M.A., Ertama, L., Katila, H., et al. (1994) Globus Pharyngis, Commonly Associated with Esophageal Motility Disorders. American Journal of Gastroenterology, 89, 503-508. |
| [62] | Moser, G., Vacariu-Granser, G.V., Schneider, C., Abatzi, T., Pokieser, P., Stacher-Janotta, G., et al. (1991) High Incidence of Esophageal Motor Disorders in Consecutive Patients with Globus Sensation. Gastroenterology, 101, 1512-1521. https://doi.org/10.1016/0016-5085(91)90386-y |
| [63] | 董泓毅, 刘殿刚. 咽喉反流中胃食管反流病相关诊断与治疗研究进展[J]. 实用临床医药杂志, 2023, 27(14): 109-114. |
| [64] | Divakaran, S., Rajendran, S., Thomas, R.M., Jacob, J. and Kurien, M. (2020) Laryngopharyngeal Reflux: Symptoms, Signs, and Presence of Pepsin in Saliva—A Reliable Diagnostic Triad. International Archives of Otorhinolaryngology, 25, e273-e278. https://doi.org/10.1055/s-0040-1709987 |
| [65] | Lechien, J.R. and Bobin, F. (2024) Diagnostic Value of Fasting and Bedtime Saliva Pepsin Measurements in Laryngopharyngeal Reflux. Biomedicines, 12, Article 398. https://doi.org/10.3390/biomedicines12020398 |
| [66] | Zhang, J., Wang, X., Wang, J., Zhao, J., Zhang, C., Liu, Z., et al. (2022) Does Hypopharyngeal-Esophageal Multichannel Intraluminal Impedance-pH Monitoring for the Diagnosis of Laryngopharyngeal Reflux Have to Be 24 H? European Archives of Oto-Rhino-Laryngology, 279, 5323-5329. https://doi.org/10.1007/s00405-022-07554-w |
| [67] | Gu, W., Chen, W., Zhang, T., Zhu, Y., Li, W., Shi, W., et al. (2024) Diagnostic Value of the Pepsin Concentration in Saliva and Induced Sputum for Gastroesophageal Reflux-Induced Chronic Cough: A Prospective Clinical Study. ERJ Open Research, 10, 00046-2024. https://doi.org/10.1183/23120541.00046-2024 |
| [68] | Krause, A.J., Greytak, M., Kessler, M. and Yadlapati, R. (2024) Pilot Study Evaluating Salivary Bile Acids as a Diagnostic Biomarker of Laryngopharyngeal Reflux. Diseases of the Esophagus, 37, doae021. https://doi.org/10.1093/dote/doae021 |
| [69] | Worrell, S.G., DeMeester, S.R., Greene, C.L., Oh, D.S. and Hagen, J.A. (2013) Pharyngeal pH Monitoring Better Predicts a Successful Outcome for Extraesophageal Reflux Symptoms after Antireflux Surgery. Surgical Endoscopy, 27, 4113-4118. https://doi.org/10.1007/s00464-013-3076-3 |
| [70] | 吴玮, 王刚, 徐小杭, 等. 胃食管气道反流性疾病提出的依据及意义[J]. 中国医学文摘(耳鼻咽喉科学), 2018, 33(1): 14-17. |
| [71] | Kavitt, R.T., Lal, P., Yuksel, E.S., Ates, F., Slaughter, J.C., Garrett, C.G., et al. (2017) Esophageal Mucosal Impedance Pattern Is Distinct in Patients with Extraesophageal Reflux Symptoms and Pathologic Acid Reflux. Journal of Voice, 31, 347-351. https://doi.org/10.1016/j.jvoice.2016.06.023 |
| [72] | Sidhwa, F., Moore, A., Alligood, E. and Fisichella, P.M. (2017) Diagnosis and Treatment of the Extraesophageal Manifestations of Gastroesophageal Reflux Disease. Annals of Surgery, 265, 63-67. https://doi.org/10.1097/sla.0000000000001907 |
| [73] | 季锋, 袁莉莉, 韩新巍, 等. 反流性咽喉炎的研究进展[J]. 中华胃食管反流病电子杂志, 2018, 5(4): 145-147. |
| [74] | Field, S.J. and Sutherland, L.R. (1998) Does Medical Antireflux Therapy Improve Asthma in Asthmatics with Gastroesophageal Reflux? A Critical Review of the Literature. Chest, 114, 275-283. https://doi.org/10.1378/chest.114.1.275 |
| [75] | 王轶, 朱生樑. 胃食管反流性咳嗽的治疗进展[J]. 医学研究生学报, 2014, 27(12): 1328-1831. |
| [76] | 赖克方, 陈如冲, 刘春丽, 等. 不明原因慢性咳嗽的病因分布及诊断程序的建立[J]. 中华结核和呼吸杂志, 2006, 29(2): 96-99. |
| [77] | 张利, 张梦茹, 阿丽米热∙艾尔肯, 等. 咽喉反流性疾病在常见呼吸道疾病中的作用[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 23-29. |
| [78] | Dong, R., Xu, X., Yu, L., Ding, H., Pan, J., Yu, Y., et al. (2019) Randomised Clinical Trial: Gabapentin vs Baclofen in the Treatment of Suspected Refractory Gastro‐Oesophageal Reflux‐Induced Chronic Cough. Alimentary Pharmacology & Therapeutics, 49, 714-722. https://doi.org/10.1111/apt.15169 |
| [79] | 胡志伟, 吴继敏, 汪忠镐. 胃食管喉气管综合征的再认识和胃镜下射频术治疗胃食管反流病的进展[J]. 中国微创外科杂志, 2015, 15(6): 558-562. |
| [80] | 吴继敏, 汪忠镐, 刘建军, 等. Stretta射频治疗以食管外症状为主的胃食管反流病[J]. 北京师范大学学报(自然科学版), 2010, 46(4): 530-533. |
| [81] | 胡志伟, 汪忠镐, 吴继敏, 等. Stretta射频治疗和腹腔镜Nissen胃底折叠术治疗胃食管反流相关性严重哮喘的比较研究[J]. 临床误诊误治, 2013, 26(7): 57-61. |
| [82] | Gardi, A., Gaddam, S., Maxwell, P., Melley, L.E., Altman, A., Ranjbar, P., et al. (2024) Laryngopharyngeal Reflux in Patients Who Received or Declined Nissen Fundoplication. Journal of Voice. https://doi.org/10.1016/j.jvoice.2024.09.032 |
| [83] | 徐磊, 叶国良. 胃食管反流病的内镜治疗现状及展望[J]. 现代实用医学, 2023, 35(10): 1267-1270. |
| [84] | 何健. 改良抗反流黏膜切除术治疗胃食管反流病的临床研究[D]: [博士学位论文]. 长沙: 中南大学, 2023. |
| [85] | 克力木∙阿不都热依木, 王浩, 麦麦提艾力∙麦麦提明. 我国胃食管反流病外科治疗现状及展望[J]. 中国实用外科杂志, 2024, 44(4): 395-397. |
| [86] | 胡志伟, 汪忠镐, 吴继敏. 胃食管反流病的外科手术治疗[J]. 外科理论与实践, 2021, 26(5): 399-403. |
| [87] | Eriksson, S.E., Sarici, I.S., Zheng, P., Gardner, M., Jobe, B.A. and Ayazi, S. (2024) Magnetic Sphincter Augmentation for Laryngopharyngeal Reflux: An Assessment of Efficacy and Predictors of Outcome. Journal of Voice. https://doi.org/10.1016/j.jvoice.2024.03.026 |
| [88] | Ward, M.A., Ebrahim, A., Kopita, J., Arviso, L., Ogola, G.O., Buckmaster, B., et al. (2019) Magnetic Sphincter Augmentation Is an Effective Treatment for Atypical Symptoms Caused by Gastroesophageal Reflux Disease. Surgical Endoscopy, 34, 4909-4915. https://doi.org/10.1007/s00464-019-07278-9 |
| [89] | Park, A., Weltz, A.S., Sanford, Z., Addo, A. and Zahiri, H.R. (2019) Laparoscopic Antireflux Surgery (LARS) Is Highly Effective in the Treatment of Select Patients with Chronic Cough. Surgery, 166, 34-40. https://doi.org/10.1016/j.surg.2019.01.036 |
| [90] | Stefanidis, D., Hope, W.W., Kohn, G.P., Reardon, P.R., Richardson, W.S. and Fanelli, R.D. (2010) Guidelines for Surgical Treatment of Gastroesophageal Reflux Disease. Surgical Endoscopy, 24, 2647-2669. https://doi.org/10.1007/s00464-010-1267-8 |
| [91] | Tustumi, F., Bernardo, W.M., Mariano da Rocha, J.R., Szachnowicz, S., Bernal da Costa Seguro, F.C., Bianchi, E.T., et al. (2021) Anti-Reflux Surgery for Controlling Respiratory Symptoms of Gastro-Esophageal Reflux Disease: A Systematic Review and Meta-Analysis. Asian Journal of Surgery, 44, 2-10. https://doi.org/10.1016/j.asjsur.2020.04.017 |
| [92] | 吴继敏, 刘健男. 胃食管反流性咳嗽的外科治疗[J]. 中华结核和呼吸杂志, 2023, 46(10): 961-964. |
