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肝性脑病的药物治疗研究进展
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Abstract:
肝性脑病(Hepatic Encephalopathy, HE)是由严重肝功能障碍或门体分流引起的脑功能紊乱，主要表现为意识障碍、记忆力下降以及注意力不集中等缺陷的神经或精神方面的改变。常见于肝硬化、急性肝衰竭等患者。基于肝性脑病的发病机制尚未明确且药物治疗旨在减少氨的产生和吸收，改善症状并预防复发存在一定的局限性，并对患者的经济条件有较大的损耗。因此，笔者从中医和西医两个方向对治疗肝性脑病的药物进行综述，为寻找有效且符合患者经济条件的药物提供重要临床参考依据。
Hepatic encephalopathy (HE) is a disorder of brain function resulting from severe hepatic insufficiency or portosystemic shunt, primarily manifested as neurological or psychiatric alterations including impaired consciousness, decreased memory, and inattention. It is commonly seen in patients with conditions such as liver cirrhosis and acute liver failure. Given that the pathogenesis of HE remains unclear and that pharmacological treatments, aimed at reducing ammonia production and absorption, alleviating symptoms, and preventing recurrence, have certain limitations and impose significant financial burdens on patients, the author conducted a comprehensive review of medications used in the treatment of HE from both traditional Chinese medicine (TCM) and western medicine perspectives. This review provides important clinical reference for identifying effective treatments that are also economically viable for patients.
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